Combined serous carcinoma and neuroendocrine carcinoma of the fallopian tube

Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

“…While the two high-grade neuroendocrine carcinomas we report occurred in pure form (with no other tumor component), it is possible that another component was present and totally overgrown by the neuroendocrine neoplasm. One of the prior reported cases of primary tubal high-grade neuroendocrine carcinoma also contained a component of serous carcinoma (6).…”

“…Neuroendocrine neoplasms occur at many sites in the body but primary neuroendocrine tumors of the fallopian tube are extremely rare with only a few case reports in the literature (1)(2)(3)(4)(5)(6). There are occasional reports of high-grade neuroendocrine carcinoma of the fallopian tube and one reported case of a carcinoid tumor (also currently variously termed low-grade/ grade 1 neuroendocrine tumor) associated with a mature cystic teratoma (1)(2)(3)(4)(5)(6). However, there have been no reports of isolated primary carcinoid tumor (not associated with a teratoma) at this location.…”

“…Primary neuroendocrine tumors of the fallopian tube are extremely rare and, in fact, the category of neuroendocrine tumor is not included in the 2014 World Health Organization (WHO) Classification of tumors of the female reproductive organs(7). There have been only occasional case reports in the literature of a primary neuroendocrine tumor at this location(1)(2)(3)(4)(5)(6). In one case, a carcinoid tumor arose within a mature cystic teratoma of the fallopian tube.…”

Rare Primary Fallopian Tube Grade 2 Neuroendocrine Tumor: A Case Report With Review of Literature

“…Theories include their derivation from a teratoma (as may be the case in 2 of the identified cases in Table 1), or that they originate from another underlying tumor. Kim et al Pathology of the Lower 10 reported a NEC that was histologically described as transitioning in areas from a typical serous carcinoma. Both tumor components strongly expressed p53 and p16, and the neuroendocrine component surrounded the serous carcinoma component.…”

“…Of these, primary fallopian tube NENs are so rare that the latest WHO Classification of female genital tumors does not list them as a separate category (1). Only a handful of cases have been reported in the literature (3)(4)(5)(6)(7)(8)(9)(10). We report a unique case of grade 2 primary NET within the fallopian tube and examine its clinical presentation, review the literature, and discuss the challenges in diagnosis and therapeutic management.…”