Combined radio-immunotherapy: An opportunity to increase the therapeutic ratio of oligometastasis-directed radiotherapy

Partial tumor irradiation plus pembrolizumab in treating large advanced solid tumor metastases

“…The combination of SBRT with immunotherapy has numerous potential advantages, and combination approaches are under intense investigation. Despite the excitement surrounding combination SBRT and immunotherapy, prospective studies investigating this treatment regimen have produced mixed results ( 8 , 9 ).…”

Neural network based ensemble model to predict radiation induced lymphopenia after concurrent chemo-radiotherapy for non-small cell lung cancer from two institutions

“…Following the completion of RTOG 9410 in the early 2010s [2] , concurrent use of Chemo-Radiotherapy (CCRT) has become the definitive treatment for unresectable Locally-Advanced Non-Small Cell Lung Cancer (LA-NSCLC). In the late 2010s, the PACIFIC trial demonstrated superior survival for the addition of Immune Checkpoint Inhibitors (ICIs) after the completion of CCRT, which quickly became the new standard of care [ 3 , 4 ], and similar regimens are studied in a range of other indications [5] .…”