Combined pre‐S deletion and core promoter mutations related to hepatocellular carcinoma: A nested case‐control study in China

Qu, Lei; Liu, Taotao; Jin, Fei; Guo, Yan‐Mei; Chen, Taoyang; Ni, Zheng-Pin; Shen, Xin

doi:10.1111/j.1872-034x.2010.00732.x

Cited by 25 publications

(30 citation statements)

References 35 publications

(74 reference statements)

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“…and restrospective cohort studies show that pre-S deletion associates with hepatocarcinogenesis [Gao et al, 2007;Lin et al, 2007;Cao et al, 2008;Chen et al, 2008;Fang et al, 2008;Abe et al, 2009;Liu et al, 2009;Qu et al, 2011], only a few studies have dealt with the association between pre-S mutations and postoperative HCC recurrence. One of these was by Yeh et al [2010] who reported that short fragment (<100 bp) pre-S deletion in non-tumorus liver tissue correlated with a decreased disease-free survival, and that a pre-S stop codon mutation was associated with better disease-free survival after resection of HCC.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, pre-S mutant LHBs can upregulate cyclooxygenase-2 and cyclin A, thereby inducing hepatocyte cell cycle progression and proliferation [Wang et al, 2005]. Several cross-sectional and case-control studies show that some mutations in the HBV pre-S region associate significantly with an increased risk of developing HCC [Gao et al, 2007;Lin et al, 2007;Cao et al, 2008;Chen et al, 2008;Fang et al, 2008;Abe et al, 2009;Qu et al, 2011].…”

Section: Introductionmentioning

confidence: 98%

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Lack of association between hepatitis B virus pre‐S mutations and recurrence after surgical resection in hepatocellular carcinoma

Heo

Lee

Park

et al. 2013

Journal of Medical Virology

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Pre-S mutation of hepatitis B virus (HBV) is known to be a risk factor for hepatocarcinogenesis. A previous study suggested that pre-S mutation(s) may associate with increased recurrence after surgical resection. In the present study, 64 patients with HBV-related hepatocellular carcinoma (HCC) were categorized into two groups according to the presence or absence of pre-S mutation(s). The clinicopathological variables of the two groups were analyzed to assess the relationship between pre-S mutations and postoperative recurrence. Nineteen patients (29.7%) had pre-S mutations;13 had a pre-S deletion, three had a pre-S2 start codon mutation, two patients had both a pre-S deletion, and a pre-S2 start codon mutation, and one patient had a pre-S2 insertion. The two groups did not differ in terms of baseline clinicopathological parameters. Cirrhosis and satellite lesion(s) were predictive factors for postoperative recurrence and poor overall survival. Recurrence-free survival (P = 0.320) and overall survival (P = 0.238) did not differ significantly when pre-S mutations were present. In conclusion, this study did not find evidence supporting the notion that pre-S mutation(s) are associated with postoperative recurrence after surgical resection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Lack of association between hepatitis B virus pre‐S mutations and recurrence after surgical resection in hepatocellular carcinoma

Heo

Lee

Park

et al. 2013

Journal of Medical Virology

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“…During the course of chronic HBV infection, a wide variety of liver diseases are observed, ranging from an asymptomatic carrier state to liver cirrhosis and HCC [16]. In our previous studies conducted in Qidong, pre- S deletion and specific mutations in BCP were confirmed to be associated with a high risk of HCC occurrence [17,18]. However, the risk of mutations in other regions of the full HBV genome was seldom reported.…”

Section: Discussionmentioning

confidence: 99%

Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China

Zhang

Liu

et al. 2016

IJMS

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A two stage study was conducted to explore new potential mutations in the full genome of hepatitis B virus (HBV) on the progression of hepatocellular carcinoma (HCC) in Qidong, China. In stage 1, full genomes of HBV were compared between 30 HCC cases and 30 controls. In stage 2, an independent case–control study including 100 HCC cases and 100 controls was enrolled to verify the relationship between hot-spot mutations and HCC development. Furthermore, a longitudinal study was conducted on 11 HCC cases with serial serum samples available before HCC diagnosis. A total of 10 mutations (including pre-S2 start codon mutation and pre-S deletion in pre-S gene, G1613A, C1653T, A1762T, and G1764A mutations in X gene, A2159G, A2189Y, G2203W, and C2288R mutations in C gene) showed an increased risk of HCC. In the validation study, pre-S deletion, C1653T, A1762T/G1764A, A2159G, A2189Y, G2203W, and C2288R mutations were associated with increased HCC risk in univariate analysis. Multivariate analysis indicated that pre-S deletion, A1762T/G1764A, A2159G, and A2189Y mutations were independently related with HCC development. Moreover, a significant biological gradient of HCC risk by number of mutations in the C gene was observed. Longitudinal observation demonstrated a gradual combination of the above mutations accumulated during the progression of HCC.

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“…Base on the inclusion criteria, only 17 case-control studies (Sakamoto et al, 2006;Tanaka et al, 2006;Shinkai et al, 2007;Wang et al, 2007;Yuan et al, 2007;Zhang et al, 2007;Fang et al, 2008;Guo et al, 2008;Jang et al, 2008;Choi et al, 2009;Ja et al, 2009;Tangkijvanich et al, 2010;Welschinger et al, 2010;Zhu et al, 2010;Cho et al, 2011;Qu et al, 2011;Tatsukawa et al, 2011) with full-text were included in this meta-analysis and 18 studies were excluded. The flow chart of study selection is summarized in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Hepatitis B Virus Gene C1653T Polymorphism Mutation and Hepatocellular Carcinoma Risk: an Updated Meta-analysis

Shi¹,

Zhang²,

Shang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Although there have been many studies investigating possible associations between the C1653T mutation and risk of HCC, the results have been inconsistent. We conducted searches of the published literature in Pubmed and Embase databases up to January 2013. Seventeen studies with a total of 1,085 HCC cases and 1,365 healthy controls were retrieved.We found a significant association between the C1653T mutation and HCC risk (OR = 2.01, 95%CI= 1.49-2.70). In the subgroup analysis by ethnicity, a significant association was also found in Asians (OR = 2.07, 95%CI= 1.71-2.51). In subgroup analysis by HBV genotype, B and C were linked with development of HCC (B:OR = 2.21, 95%CI= 1.13-4.34; C:OR = 2.26, 95%CI= 1.61-3.16). However, no significant association was found between the C1653T mutation and HCC risk in HBeAg positive cases. In conclusion, this meta-analysis suggests that the C1653T mutation may be associated with susceptibility to HCC.

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Combined pre‐S deletion and core promoter mutations related to hepatocellular carcinoma: A nested case‐control study in China

Abstract: AFP levels >20 ng/mL, high HBV DNA levels, pre-S deletion, and T1762/A1764 double mutations at recruitment were independent risk factors of HCC. Combination of pre-S deletion and core promoter mutations increased the risk of HCC.

Cited by 25 publications

References 35 publications

Lack of association between hepatitis B virus pre‐S mutations and recurrence after surgical resection in hepatocellular carcinoma

Lack of association between hepatitis B virus pre‐S mutations and recurrence after surgical resection in hepatocellular carcinoma

Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China

Hepatitis B Virus Gene C1653T Polymorphism Mutation and Hepatocellular Carcinoma Risk: an Updated Meta-analysis

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