Hepatitis B Virus Gene C1653T Polymorphism Mutation and Hepatocellular Carcinoma Risk: an Updated Meta-analysis

Shi, Hongyan; Zhang, Jun; Shang, Xue-Chai; Xie, Xinyou

doi:10.7314/apjcp.2013.14.2.1043

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…G1613A and C1653T double mutations, which were recently identified, were frequently found in patients with HCC. Moreover, A single G1613A mutation was associated with future emergence of HCC (Tatsukawa et al, 2011), and a single C1653T mutation in the ORF C gene region are independent factor for development of HCC, However, no significant association was found between the C1653T matant and HCC risk in HBeAg positive patients (Tanaka et al, 2006;Shi et al, 2013).…”

Section: Secondary Mutations In Pre-c/c Genes and Risk Of Hccmentioning

confidence: 96%

Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis

Liang¹,

Chen²,

Tang³

2013

Asian Pacific Journal of Cancer Prevention

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Section: Secondary Mutations In Pre-c/c Genes and Risk Of Hccmentioning

confidence: 96%

Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis

Liang¹,

Chen²,

Tang³

2013

Asian Pacific Journal of Cancer Prevention

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“…Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and ranks third in global cancer deaths [1]. The occurrence and development of HCC varies widely among ethnic groups, regions and individuals [2], and epidemiological investigation have shown that 60% of the more than 700,000 new HCC cases annually are caused by chronic hepatitis B virus (HBV) infection and are distributed with the epidemic characteristics of HBV [3].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma

Guo

Huang

2017

Clin Mol Hepatol

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Background/AimsThe association between the kinesin family member 1B (KIF1B) gene polymorphism and the risk of hepatitis B virus-related hepatocellular carcinoma (HCC) has been investigated in many peer-reviewed studies. However, scholars have failed to replicate these results in validation tests. The purpose of the present study was to explore whether the KIF1B rs17401966 polymorphism was associated with susceptibility to HCC.MethodsThe results of case-controlled studies on the correlation between the KIF1B rs17401966 polymorphism and HCC susceptibility were collected using Google Scholar and the EMBASE, PubMed and CNKI databases. Based on inclusion and exclusion criteria, 5 papers with a total of 12 cohorts were included in this study.ResultsThe 12 cohorts were integrated, and the results showed that the rs17401966 polymorphism reduced the risk for HCC under the allele, heterozygous, homozygous, and dominant models but not under the additive or recessive models. Moreover, the merged results showed strong heterogeneity, and the cumulative meta-analysis results were unreliable. A genetic differentiation analysis of the 12 cohorts found different degrees of genetic differentiation between the 5 cohorts in Zhang et al.’s study and the cohorts in the other studies. We further divided the 12 study cohorts into 2 subgroups based on fixation index value; however, the results of that analysis were inconsistent.ConclusionsThe results of this meta-analysis were not able to verify the association between the KIF1B rs1740199 polymorphism and HCC risk. Therefore, a well-designed, large-scale, multicenter validation study is needed to confirm the relationship.

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“…Previously, the association of mutations in Enh-II region with the development of advanced liver disease were not investigated in this area. Various studies around the globe suggested that certain mutations in the HBV genome may be associated with HCC development [ 26 , 27 ]. It is considered that mutations in HBV genome may responsible for escape from the host immune system and may affect the oncogenic potential inchronic HBV diseases [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic diversity in enhancer II region of HBV genotype D and its association with advanced liver diseases

Khan

Gondal³

et al. 2022

PLoS ONE

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Background Hepatitis B Virus (HBV) is one of the most common human infectious agents, and the mutations in its genome may cause chronic hepatitis (CH), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). This study was designed to characterize the enhancer-II (Enh-II) region of X gene in HBV positive patients to assess the association of such mutations with CH, LC, and HCC. Methods HBV positive samples (N = 200) with patients’ demographic and clinical data were collected from different regions of Khyber Pakhtunkhwa (KP), Pakistan. The Enh-II region of the HBx gene was sequenced and zanalyzed for polymorphism associated with advanced liver disease. Univariate and logistic regression analyses were performed to evaluate potent mutations associated with a risk for LC and HCC. Results HBV Enh-II region sequences analysis revealed 25 different mutations. The highest frequency of mutations S101F (62.2%), A102V/R/G/I (56.25%), M103L/A (68.75%)were found in HCC, followed in LC and CH patients as 57.1%, 42.8%, 28.52% 16%, 15.2% and 18.4% respectively. H94 deletion in the α-box of the Enh-II region, associated with a high risk of HCC was found in half of the HCC patients. This deletion was present in 28.5% of LC and 6.5% of CH patients. Importantly, the high frequency of some notable mutations such as E109A/Y, A110S/K, Y111D/E, and F112L was first time reported in the entire study population. The frequencies of these mutations were high in HCC (43.75%, 37.5%, 50% and 43.75% respectively) as compared to LC (14.28%, 14.28%, 28.2% and 42.8%) and CH patients (12.8%, 15.2%, 16.8% and 16% respectively). Conclusion Mutations associated with LC and HCC are prevalent in the Enh-II region in Pakistani HBV isolates. The mutations found are alarming in CH patients as these may progress to LC and HCC in a large number of patients.

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Hepatitis B Virus Gene C1653T Polymorphism Mutation and Hepatocellular Carcinoma Risk: an Updated Meta-analysis

Cited by 4 publications

References 33 publications

Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis

Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis

Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma

Genetic diversity in enhancer II region of HBV genotype D and its association with advanced liver diseases

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