Combined methotrexate-ultraviolet B therapy in the treatment of psoriasis

Methotrexate plus narrowband UVB phototherapy versus narrowband UVB phototherapy alone in the treatment of plaque-type psoriasis: A randomized, placebo-controlled study

“…Our results compare favorably with those obtained from similar studies. 15,16 The fact that NB UVB alone cleared only 38.5% of our patients warrants discussion as this clearance rate may not represent typical results normally obtained from this modality. Our explanations are 2-fold.…”

“…14 This combination, although first reported in 1982, 15 is not mentioned even in some extensive reviews. 5 In their study, Paul et al 15 reported that all 26 patients were cleared after a mean of 12 broadband UVB treatments and 7 weeks of MTX intake. The mean cumulative MTX dose to achieve clearance was 112 mg (range 75-165 mg).…”

Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference

“…52,53 Phototherapy, including broadband ultraviolet B, narrowband UVB, and PUVA, has been used very effectively in combination with methotrexate. [54][55][56] Photosensitivity has been reported rarely, as has the even more uncommon radiation recall in which a patient's resolved sunburn can re-flare in the same locations after taking methotrexate. Methotrexate has also been combined with all of the biologic therapies that are now approved for the treatment of psoriasis or psoriatic arthritis.…”

Combination therapy to treat moderate to severe psoriasis

“…They were treated with an increased amount or frequency of UVB treatments. 39 Methotrexate and PUVA. Although it has been suggested that combined methotrexate and PUVA may predispose patients to an increase in squamous cell carcinomas, the combination has been effective in patients whose psoriasis is refractory to other treatments.…”