Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study

Surov, Alexey; Meyer, Hans Jonas; Höhn, Anne Kathrin; Sabri, Osama; Purz, Sandra

doi:10.1016/j.tranon.2018.08.018

Cited by 16 publications

(16 citation statements)

References 35 publications

(74 reference statements)

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“…It has already been reported that SUV max is related to K ep P10, and that P25 and TLG tended to be related to K ep P25 and K trans P10 in primary HNSCCs [19]. Moreover, it has been suggested that the evidence of these correlations may also depend on tumor grading, with G1/G2 PTs showing significant associations, while no correlations are evident in G3 PTs [19,13]. This may partially explain the lack of correlations in PTs emerging from our study: in our cohort, HPV-negative OPSCCs were predominately G3 (13/19 patients) while no grading system currently exists for HPV-positive OPSCCs according to the American Joint Committee on Cancer Staging Manual [30].…”

Section: Plos Onementioning

confidence: 94%

“…Considering the volume of data that can be derived from both histology and functional imaging, radiologists and clinicians should be aware of the different potential roles of several biomarkers with respect to specific clinical end points. To this purpose, a number of reports have recently evaluated the complementarity and/or associations between imaging and histopathological features in HNSCC [10][11][12][13][14][15], as well as in different malignancies, i.e. breast cancer, lung adenocarcinoma and glioma [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

et al. 2020

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Objectives To investigate the correlation between histogram-based Dynamic Contrast-Enhanced magnetic resonance imaging (DCE-MRI) parameters and positron emission tomography with 18 F-fluorodeoxyglucose (18 F-FDG-PET) values in oropharyngeal squamous cell carcinoma (OPSCC), both in primary tumors (PTs) and in metastatic lymph nodes (LNs). Methods 52 patients with a new pathologically-confirmed OPSCC were included in the present retrospective cohort study. Imaging including DCE-MRI and 18 F-FDG PET/CT scans were acquired in all patients. Both PTs and the largest LN, if present, were volumetrically contoured. Quantitative parameters, including the transfer constants, K trans and K ep , and the volume of extravascular extracellular space, v e , were calculated from DCE-MRI. The percentiles (P), P10, P25, P50, P75, P90, and skewness, kurtosis and entropy were obtained from the histogram-based analysis of each perfusion parameter. Standardized uptake values (SUV), SUV max , SUV peak , SUV mean , metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated applying a SUV threshold of 40%. The correlations between all variables were investigated with the Spearman-rank correlation test. To exclude false positive results under multiple testing, the Benjamini-Hockberg procedure was applied.

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Section: Plos Onementioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

et al. 2020

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“…However, their patient population underwent surgery, and sub-optimal delineation of only one imaging technique was performed. Although in advanced tumors SUV max /ADC min , SUV max /ADC mean and TLG/ADC min correlated with cellularity, Ki67 and HIF-1a [47], no prognostic tests were performed. Chan et al [21] found that a combination of PET heterogeneity (uniformity), DCE-MRI parameters and clinical risk factors was most predictive for LR and OS.…”

Section: Tablementioning

confidence: 99%

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Martens

Noij

Zwezerijnen

et al. 2019

European Journal of Radiology

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Background and purpose: In head and neck squamous cell carcinoma (HNSCC) (chemo)radiotherapy is increasingly used to preserve organ functionality. The purpose of this study was to identify predictive pretreatment DWI-and 18 F-FDG-PET/CT-parameters for treatment failure (TF), locoregional recurrence (LR) and death in HNSCC patients treated by (chemo)radiotherapy. Materials and methods: We retrospectively included 134 histologically proven HNSCC patients treated with (chemo)radiotherapy between 2012-2017. In 58 patients pre-treatment DWI and 18 F-FDG-PET/CT were performed, in 31 patients DWI only and in 45 patients 18 F-FDG-PET/CT only. Primary tumor (PT) and largest lymph node (LN) metastasis were quantitatively assessed for TF, LR and death. Multivariate analysis was performed for 18 F-FDG-PET/CT and DWI separately and thereafter combined. In patients with both imaging modalities, positive and negative predictive value in TF and differences in LR and death, were assessed. Results: Mean follow-up was 25.6 months (interquartile-range; 14.0-37.1 months). Predictors of treatment failure, corrected for TNM-stage and HPV-status, were SUV max-PT , ADC max-PT , total lesion glycolysis (TLG-LN), ADCp20-LN (P = 0.049, P = 0.024, P = 0.031, P = 0.047, respectively). TLG-PT was predictive for LR (P = 0.003). Metabolic active tumor volume (MATV-PT) (P = 0.003), ADC GTV-PT (P < 0.001), ADCSD (P = 0.048) were significant predictors for death. In patients with both imaging modalities SUV max-PT remained predictive for treatment failure (P = 0.049), TLG-LN for LR (P = 0.003) and ADC GTV-PT for death (P < 0.001). Higher predictive value for treatment failure was found for the combination of SUV max-PT and ADC max-PT , compared to either one separately. Conclusion: Both DWI-and 18 F-FDG-PET/CT-parameters appear to have predictive value for treatment failure, locoregional recurrence and death. Combining SUV max-PT and ADC max-PT resulted in better prediction of treatment failure compared to single parameter assessment.

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“…A multicenter and prospective study with more patients could be more representative of the population. Surov et al found that more complex PET- and DWI-based parameters proved useful to reflect several histopathological parameters ( 37 ). However, our study included only the conventional parameters, which might be one of the limitations of this research.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Diffusion, Glucose Metabolism Parameters of PET/MR in Patients With Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy

Kedves¹,

Tóth²,

Emri³

et al. 2020

Front. Oncol.

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Purpose: This study aims to evaluate the predictive value of the pretreatment, metabolic, and diffusion parameters of a primary tumor assessed with PET/MR on patient clinical outcomes. Methods: Retrospective evaluation was performed using PET/MR image data sets acquired using the single tracer injection dual imaging of 68 histologically proven head and neck cancer patients 4 weeks before receiving definitive chemoradiotherapy (CRT). PET/MR was performed before the CRT and 12 weeks after the CRT for response evaluation. Image data (PET and MRI diffusion-weighted imaging [DWI]) was used to specify the maximum standard uptake value, the peak lean body mass corrected, SUV max , the metabolic tumor volume, the total lesion glycolysis (SUV max , SUL peak , MTV, and TLG), and the mean apparent diffusion coefficient (ADC mean ) of the primary tumor. Based on the results of the therapeutic response evaluation, two patient subgroups were created: one with a viable tumor and another without. Metabolic and diffusion data, from the pretreatment PET/MR and the therapeutic response, were correlated using Spearman's correlation coefficient and Wilcoxon's test. Results: After completing the CRT, a viable residual tumor was detected in 36/68 (53%) cases, and 32/68 (47%) patients showed complete remission. However, no significant correlation was found between the pretreatment parameter, ADC mean ( p = 0.88), and the therapeutic success. The PET parameters, SUV max and SUL peak , MTV, and TLG ( p = 0.032, p = 0.01, p < 0.0001, p = 0.0004) were statistically significantly different between the two patient subgroups. Conclusion: This study found that MRI-based (ADC mean ) data from FDG PET/MR pretreatment could not be used to predict therapeutic response although the PET parameters SUV max , SUL peak , MTV, and TLG proved to be more useful; thus, their inclusion in risk stratification may also be of additional value.

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Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study

Cited by 16 publications

References 35 publications

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Predictive Value of Diffusion, Glucose Metabolism Parameters of PET/MR in Patients With Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy

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