Combined Medical and Surgical Approach Improves Healing of Septic Perianal Crohn's Disease

Choi, Christine S.; Berg, Arthur; Sangster, William; Schieffer, Kathleen M.; Harris, Leonard; Deiling, Sue; Koltun, Walter A.

doi:10.1016/j.jamcollsurg.2016.05.017

Cited by 17 publications

(5 citation statements)

References 38 publications

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“…Of these, 166 were included in the full text review. Seventy‐six were further excluded, leaving 90 studies for data extraction [17–106] (Figure 1). Of the 90 studies, there were 53 retrospective studies, 16 prospective observational studies, 16 RCTs, four case series and one cross‐sectional study.…”

Section: Resultsmentioning

confidence: 99%

The use of core descriptors from the ENiGMA code study in recent literature: a systematic review

Khan,

Arline,

Williams

et al. 2024

Colorectal Disease

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AimThe heterogeneity in data quality presented in studies regarding Crohn's anal fistula (CAF) limit extrapolation into clinical practice. The ENiGMA collaborators established a core descriptor set to standardize reporting of CAF. The aim of this work was to quantify the use of these descriptors in recent literature.MethodWe completed a systematic review of PubMed and the Cochrane Library, extracting publications from the past 10 years specific to the clinical interventions and outcomes of CAF, and reported in line with PRISMA guidance. Each article was assessed for inclusion of ENiGMA descriptors. The median number of descriptors per publication was evaluated along with the overall frequency of each individual descriptor. Use of ENiGMA descriptors was compared between medical and procedural publications.ResultsNinety publications were included. The median number of descriptors was 15 of 37; 16 descriptors were used in over half of the publications while 17 were used in fewer than a third. Descriptors were more frequently used in procedural (n = 16) than medical publications (n = 14) (p = 0.031). In procedural publications, eight descriptors were more frequently used including Faecal incontinence, Number of previous fistula interventions, Presence and severity of anorectal stenosis and Current proctitis. Medical publications were more likely to include Previous response to biological therapy and Duration and type of current course of biological therapy.ConclusionWith many descriptors being used infrequently and variations between medical and procedural literature, the colorectal community should assess the need for all 37 descriptors.

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Section: Resultsmentioning

confidence: 99%

The use of core descriptors from the ENiGMA code study in recent literature: a systematic review

Khan,

Arline,

Williams

et al. 2024

Colorectal Disease

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“…Their treatment algorithm appears to be quite successful. 36 In the past, therapy has been increased in a stepwise fashion to achieve remission, adding increasingly potent immunosuppressant medications. The value of early combination therapy to prevent disease progression may find a role in fistulizing pCD (REACT trial), 37 or the addition of anti-TNF agents earlier in therapy.…”

Section: Treatmentmentioning

confidence: 99%

Perianal Crohn's disease: challenges and solutions

Kelley

Kaur

Tsikitis

2017

CEG

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Perianal Crohn’s disease affects a significant number of patients with Crohn’s disease and is associated with poor quality of life. The nature of the disease, compounded by presentation of various disease severities, has made the treatment of perianal Crohn’s disease difficult. The field continues to evolve with the use of both historical and contemporary solutions to address the challenges associated with it. The goal of this article is to review current literature regarding medical and surgical treatment, as well as the future directions of therapy.

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“…6,17,19 Despite all available medical and surgical interventions, 8% to 19% of patients with PFCs eventually undergo permanent diverting ostomy. 17,19,20 Prevention of PFC development through effective medical treatments could lead to better outcomes. However, the epidemiology and progression of PFCs are not well understood, and evidence for effective preventive strategies is lacking.…”

Section: Introductionmentioning

confidence: 99%

“…About 70% of patients with PFCs eventually undergo surgical interventions, which often provide only temporary relief . Despite all available medical and surgical interventions, 8% to 19% of patients with PFCs eventually undergo permanent diverting ostomy . Prevention of PFC development through effective medical treatments could lead to better outcomes.…”

Section: Introductionmentioning

confidence: 99%

Association Between Steroid-Sparing Therapy and the Risk of Perianal Fistulizing Complications Among Young Patients With Crohn Disease

et al. 2020

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IMPORTANCE Perianal fistulizing complications (PFCs) develop in 15% to 30% of patients with Crohn disease (CD), are difficult to treat, worsen quality of life, increase cost of care, and commonly recur. Evidence-based strategies to prevent PFCs are lacking. OBJECTIVES To investigate the effectiveness of medical therapy for reducing risk of PFCs among young people with CD and to test the hypothesis that steroid-sparing therapy (SST) use would be associated with reduced risk of PFC development.

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Combined Medical and Surgical Approach Improves Healing of Septic Perianal Crohn's Disease

Cited by 17 publications

References 38 publications

The use of core descriptors from the ENiGMA code study in recent literature: a systematic review

The use of core descriptors from the ENiGMA code study in recent literature: a systematic review

Perianal Crohn's disease: challenges and solutions

Association Between Steroid-Sparing Therapy and the Risk of Perianal Fistulizing Complications Among Young Patients With Crohn Disease

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Combined Medical and Surgical Approach Improves Healing of Septic Perianal Crohn's Disease

Cited by 17 publications

References 38 publications

The use of core descriptors from the ENiGMA code study in recent literature: a systematic review

The use of core descriptors from the ENiGMA code study in recent literature: a systematic review

Perianal Crohn&#39;s disease: challenges and solutions

Association Between Steroid-Sparing Therapy and the Risk of Perianal Fistulizing Complications Among Young Patients With Crohn Disease

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Product

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Perianal Crohn's disease: challenges and solutions