Combined magnetic porous molecularly imprinted polymers and deep eutectic solvents for efficient and selective extraction of aristolochic acid I and II from rat urine

Sample Preparation Using Molecularly Imprinted Polymers

“…An example of particles produced using Fe3O4@SiO2 NPs as core particles is provided in Figure 7e. Among these studies, Li et al, who produced a layer of MIP by polycondensation of melamine, resorcinol, and formaldehyde in the pores of a mesoporous silica layer, used as sacrificial support, showed the effect of polymerization time on the adsorption capacity as well as on the selectivity of the MIP particles which reached an optimum after 3 h. 173 Other types of particles, such as silanized-hollow Fe3O4 microspheres, 44 graphite flakes coated by Fe3O4 NPs and further silanized, 33 Fe3O4 NPs covered by a mesoporous silica layer and further covered by GO 177 or GO coated with Fe3O4 NPs 94 and further vinilyzed 178 or covered by a mesoporous silica layer before being vinylized, 179 graphene-CNTs grafted with Fe3O4 NPs, 180 CNTs covered by a SiO2 layer, 118 silanized magnetic mesoporous carbon particles, 181 cobaltbased magnetic nanoporous carbon prepared from MOF, 182 and modified-β-cyclodextrin silanized Fe3O4 NPs 183 were also recently reported. Magnetic properties were also obtained by the grafting of Fe3O4 NPs at the end of the synthesis of the MIP previously prepared at the surface of mesoporous silica 51 or by the in situ growth of Fe3O4 NPs in the pores of the mesoporous imprinting silica prepared by a sol-gel approach with the presence of a surfactant.…”

“…If it affects the binding capacity, it also affects the final magnetic properties of the resulting particles. Indeed, for MIPs prepared on the surface of silanized Fe3O4 NPs, saturation magnetization values (SMVs) decrease only slightly in some cases, by a factor of 1.2 to 2, 94,106,174,181 but much more in other cases with losses by a factor of 3-5.3, 113,114,168,169,185 7, 167,179 and even 11.4. 42 In one of these studies, the decrease by a factor of 5.3 was correlated to a too large thickness of the MIP layer (15 nm) covering NPs of 520 nm.…”

“…Another application field is the monitoring of toxins or natural hormones in waters, 94 food 117,168,182 and biological fluids. 181 At last, recent works reported the use of dSPE-MIP for the extraction of pesticides from waters, 160,167 soil, 167 and food extracts, 144,162,185 and of industrial pollutants from waters, 31,33,37,47,158,166,179,183,186 food, 34,68,96,98,180,183 or samples collected in an industrial bioreactor. 53 Another objective of sample purification using MIP is the removal of a class of compounds that interfere with the analysis of the target analytes.…”

Isolation of aristolochic acid I from herbal plant using molecular imprinted polymer composited ionic liquid‐based zeolitic imidazolate framework‐67

“…Ge et al. synthesized hybrid magnetic mesoporous carbon‐molecularly imprinted polymers as the SPE sorbent to separate AAI and AAII from urine samples .…”

“…Xiao et al used a precipitation method to synthesis a MIP sorbent for adsorption of AAI in a tube [12]. Ge et al synthesized hybrid magnetic mesoporous carbon-molecularly imprinted polymers as the SPE sorbent to separate AAI and AAII from urine samples [13].…”