Sample Preparation Using Molecularly Imprinted Polymers

Pichon, Valérie; Delaunay, Nathalie; Combès, Audrey

doi:10.1021/acs.analchem.9b04816

Cited by 146 publications

(69 citation statements)

References 202 publications

(1,265 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their stability, ease of preparation, and low cost for most target analytes make them attractive for the extraction of different classes of compounds (pesticides, drugs, emerging contaminants, proteins, and natural products such as toxins) from various complex samples (environmental samples, food extracts, beverages, biological fluids, etc.) [6,7]. Numerous papers related to the development of MIPs for toxins are summarized in Table 3.…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

“…A molecular recognition mechanism can also be implemented using molecularly imprinted polymers (MIPs), whereby synthesis leads to the formation of specific cavities mimicking the recognition site of antibodies [6,7]. Another selective support, called oligosorbent (OS), has been also recently developed using aptamers immobilized onto a solid support.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunoaffinity Extraction and Alternative Approaches for the Analysis of Toxins in Environmental, Food or Biological Matrices

Delaunay

Combès

Pichon

2020

Toxins

Self Cite

View full text Add to dashboard Cite

The evolution of instrumentation in terms of separation and detection allowed a real improvement of the sensitivity and analysis time. However, the analysis of ultra-traces of toxins in complex samples requires often a step of purification and even preconcentration before their chromatographic analysis. Therefore, immunoaffinity sorbents based on specific antibodies thus providing a molecular recognition mechanism appear as powerful tools for the selective extraction of a target molecule and its structural analogs to obtain more reliable and sensitive quantitative analysis in environmental, food or biological matrices. This review focuses on immunosorbents that have proven their efficiency in selectively extracting various types of toxins of various sizes (from small mycotoxins to large proteins) and physicochemical properties. Immunosorbents are now commercially available, and their use has been validated for numerous applications. The wide variety of samples to be analyzed, as well as extraction conditions and their impact on extraction yields, is discussed. In addition, their potential for purification and thus suppression of matrix effects, responsible for quantification problems especially in mass spectrometry, is presented. Due to their similar properties, molecularly imprinted polymers and aptamer-based sorbents that appear to be an interesting alternative to antibodies are also briefly addressed by comparing their potential with that of immunosorbents.

show abstract

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunoaffinity Extraction and Alternative Approaches for the Analysis of Toxins in Environmental, Food or Biological Matrices

Delaunay

Combès

Pichon

2020

Toxins

Self Cite

View full text Add to dashboard Cite

show abstract

“…[20] reviewed the MIPs for the analysis of organic pollutants in environmental water samples, and Pichon et al. [21] examined the new strategies to develop different MIPs for various sample pretreatment methods in recent 2 years, where the applications of MISPE were simply reviewed. However, none has systematically surveyed the advances and applications of MISPE for analyzing various kinds of real samples during 2015−2020, including environmental, food, biological, and pharmaceutical samples.…”

Section: Introductionmentioning

confidence: 99%

Recent advances and applications of molecularly imprinted polymers in solid‐phase extraction for real sample analysis

Chen

Wang

et al. 2021

J of Separation Science

View full text Add to dashboard Cite

Sample pretreatment is essential for the analysis of complicated real samples due to their complex matrices and low analyte concentrations. Among all sample pretreatment methods, solid‐phase extraction is arguably the most frequently used one. However, the majority of available solid‐phase extraction adsorbents suffer from limited selectivity. Molecularly imprinted polymers are a type of tailor‐made artificial antibodies and receptors with specific recognition sites for target molecules. Using molecularly imprinted polymers instead of conventional adsorbents can greatly improve the selectivity of solid‐phase extraction, and therefore molecularly imprinted polymer‐based solid‐phase extraction has been widely applied to separation, clean up and/or preconcentration of target analytes in various kinds of real samples. In this article, after a brief introduction, the recent developments and applications of molecularly imprinted polymer‐based solid‐phase extraction for determination of different analytes in complicated real samples during the 2015‐2020 are reviewed systematically, including the solid‐phase extraction modes, molecularly imprinted adsorbent types and their preparations, and the practical applications of solid‐phase extraction to various real samples (environmental, food, biological, and pharmaceutical samples). Finally, the challenges and opportunities of using molecularly imprinted polymer‐based solid‐phase extraction for real sample analysis are discussed.

show abstract

“…In the past three years, a series of excellent reviews focused on the preparation [5][6][7] and application of MIPs [8][9][10][11][12][13][14][15][16][17][18] have been published. In those review articles, 2,6,7 the brief history of the molecular imprinting technique, the type of molecular imprinting (including noncovalent imprinting, covalent imprinting, semicovalent imprinting), and the essential elements of molecular imprinting like functional monomer, cross-linker, target template, initiators and porogens have been introduced in detail many times.…”

Section: Introductionmentioning

confidence: 99%

Designing and controlling the morphology of spherical molecularly imprinted polymers

Tian

Wang

et al. 2020

Mater. Adv.

View full text Add to dashboard Cite

show abstract

Sample Preparation Using Molecularly Imprinted Polymers

Cited by 146 publications

References 202 publications

Immunoaffinity Extraction and Alternative Approaches for the Analysis of Toxins in Environmental, Food or Biological Matrices

Immunoaffinity Extraction and Alternative Approaches for the Analysis of Toxins in Environmental, Food or Biological Matrices

Recent advances and applications of molecularly imprinted polymers in solid‐phase extraction for real sample analysis

Designing and controlling the morphology of spherical molecularly imprinted polymers

Contact Info

Product

Resources

About