Combined Factor V and VIII Deficiency

Kashoub, Masoud; Al-Amri, Usama; Saifudeen, Abdul R.; Al-Khabori, Murtadha

doi:10.5001/omj.2018.51

Cited by 1 publication

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“…Дефицит этих белков приводит к затруднению поступления FV и FVIII из гепатоцитов в кровоток и, соответственно, снижению активности FV и FVIII в плазме. Клинические проявления этого заболевания представлены различными по интенсивности и источнику кровотечениями [8][9][10][11]. Наиболее частыми являются кожный геморрагический синдром, кровотечения из слизистых оболочек, посттравматические, хирургические, акушерские кровотечения, меноррагии [12,13].…”

Section: Introductionunclassified

Diagnosis and choice of haemostatic therapy during surgery in patients with combined coagulation factor V and VIII defi ciency

Yakovleva¹,

Ефимов²,

Костин³

et al. 2021

Gematologiâ i transfuziologiâ

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Introduction. Among the most common congenital coagulopathies are haemophilia and Von Willebrand disease. These illnesses are often mimicked by orphan hereditary coagulopathies, including combined coagulation factor V and VIII deficiency.Aim — description of a clinical presentation, hampered diagnosis and choice of haemostatic therapy in a surgical patient with combined blood coagulation factor V and VIII deficiency.Main findings. We describe a clinical case of congenital combined factor V and VIII deficiency and detail the aetiology, frequency, localisation and intensity of haemorrhages. Comorbidity and surgical indications are demonstrated to require an inter-specialty medical involvement.

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