Combined exposure to cyanobacterial biomass, lead and the Newcastle virus enhances avian toxicity

Pikula, Jiří; Banďouchová, Hana; Hilscherová, Klára; Pašková, Veronika; Sedláčková, Jana; Adamovský, Ondřej; Knotková, Z.; Lány, P.; Machát, Jiří; Maršálek, Blahoslav

doi:10.1016/j.scitotenv.2010.07.050

Cited by 19 publications

(14 citation statements)

References 44 publications

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“…It has previously been shown that experiments to examine combination toxicity of multiple stressors can provide environmentally relevant data and a better insight into real toxicological problems in wildlife Pikula et al 2010). Our findings indicate that, apart from the reported nephrotoxicity of diclofenac, hepatic toxicity should also be considered.…”

Section: Discussionmentioning

confidence: 63%

“…N = 10 randomly selected males in each group, **= P < 0.01 compared to the control group. from the digestive tract within 10 days of administration and are known to exert sublethal effects (Pikula et al 2010). Likewise, the above-mentioned dose of diclofenac results in sublethal effects according to Hussain et al (2008).…”

Section: Discussionmentioning

confidence: 99%

“…As shown by comparison of Figs 1 and 2, liver damage scores differed significantly from controls both in single and combined exposures, with a significant increase only in the combined exposure when evaluated by biochemistry. Hepatocellular cytoplasmic vacuoles represent early dystrophic changes that are reversible when the cause is removed; they are non-specific and may develop due to exposure of birds to many different toxins (Pikula et al 2010;Skocovska et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Exposure of birds to multiple stressors elicits physiological costs and trade-off responses that may be represented by oxidative stress as a non-specific biochemical process (Constantini and Møller 2009).While sub-lethal adverse effects are underreported in ecotoxicology (Pikula et al 2010), various interactions, e.g. synergistic effects between natural stressors and environmental pollutants, are common (Fry 1995;Holmstrup et al 2010).…”

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confidence: 99%

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Oxidative stress and liver damage in birds exposed to diclofenac and lead

et al. 2014

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Responses of wildlife to multiple stressors fit in the ecological concept of trade-off. While toxicity of non-steroidal anti-inflammatory drugs and heavy metals for free-ranging birds has been shown in single exposures, the present study aims to evaluate oxidative stress, and liver and kidney damage caused by single and combined effects of diclofenac and lead in the Japanese quail. Forty Japanese quail (Coturnix coturnix japonica) were divided into equal groups of controls, diclofenac, Pb, and Pb+diclofenac exposures. The birds were exposed to the respective chemicals through insertion of lead shots (1.5 g) into the crop on day 0 of the experiment and/ or administration of 5 mg/kg of diclofenac intramuscularly in two treatments on days 0 and 5. Groups in liver and kidney tissues of birds were then compared after 10 days using histopathology and biochemistry markers such as glutathione reductase (GR), ferric reducing antioxidant power (FRAP), and lipid peroxidation measured as total thiobarbituric acid reactive species (TBARS). The liver damage score gradient was Pb+diclofenac exposure group > Pb exposure group > diclofenac exposure group and hepatic TBARS values were significantly increased in the group of birds exposed to a combination of diclofenac and lead compared to the healthy control group. The study has shown that, apart from the reported nephrotoxicity of diclofenac, hepatic toxicity should also be considered. Avian clinicians should be cautious when selecting drugs for therapy of wild birds with unknown history of exposure to toxic substances. Total antioxidant capacity, lipid peroxidation, non-steroidal anti-inflammatory drugs, heavy metals, Japanese quail

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Oxidative stress and liver damage in birds exposed to diclofenac and lead

et al. 2014

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“…There is increasing recognition that other environmental stressors, such as contaminants and infectious pathogens, can influence an animal's susceptibility to the effects of phycotoxins (Pikula et al, 2010) or vice versa (Benson et al, 2011). It is unknown whether the co-occurrence of high levels of mercury in some of the affected coyotes in this study may have altered their susceptibility to brevetoxin effects.…”

Section: Discussionmentioning

confidence: 87%