Combined exposure of heat stress and ozone enhanced cognitive impairment via neuroinflammation and blood brain barrier disruption in male rats

Zhang, Yan; Liu, Yumei; Wu, Weidong; Jiang, Yuhan; Zhuo, Lai-Bao

doi:10.1016/j.scitotenv.2022.159599

Cited by 15 publications

(9 citation statements)

References 58 publications

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“…The increase in TNF-α can then be attributed to ozone exposure during exercise, and elevated levels may reflect systemic inflammation and activation of the innate immune system [ 55 ]. Ozone exposure can increase the levels of TNF-α, disrupt blood brain barrier permeability, and result in neuroinflammation [ 56 ]. In the present study, supplementation with a polyphenol powder providing anthocyanins for 7-days preceding the exercise trials did not attenuate the increase in TNF-α.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Polyphenol Supplementation on BDNF, Cytokines and Cognition in Trained Male Cyclists following Acute Ozone Exposure during High-Intensity Cycling

Morton,

Paton,

Braakhuis

2024

Nutrients

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The neurotoxic effects of ozone exposure are related to neuroinflammation and increases in reactive oxygen species (ROS). This study aimed to assess inflammation, Brain-Derived Neurotrophic Factor (BDNF), and cognition in healthy male cyclists following polyphenol supplementation and exercise in an ozone-polluted environment. Ten male cyclists initially completed a maximal incremental test and maximal effort 4 km time trial in ambient air. Cyclists then completed two trials in an ozone-polluted environment (0.25 ppm) following 7 days of supplementation with either polyphenol (POLY) or placebo (PL). Experimental trials consisted of a three-stage submaximal test followed by a 4 km time trial. Blood samples were drawn pre- and post-exercise, and analyzed for BDNF, interleukin 6 (IL-6), interleukin 10 (IL-10) and tumor necrosis factor (TNF-α). The Stroop test and serial subtraction task were performed before ozone exposure and again after the 4 km TT. Serum BDNF increased post-exercise (p < 0.0001), and positive differences were observed post-exercise in the ozone POLY group relative to PL (p = 0.013). Plasma IL-6 increased post-exercise (p = 0.0015), and TNF-α increased post-ozone exposure (p = 0.0018). There were no differences in Stroop or serial subtraction tasks pre- or post-exercise. Exercise increases BDNF in ozone.

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Section: Discussionmentioning

confidence: 99%

The Effects of Polyphenol Supplementation on BDNF, Cytokines and Cognition in Trained Male Cyclists following Acute Ozone Exposure during High-Intensity Cycling

Morton,

Paton,

Braakhuis

2024

Nutrients

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“… 7 , 37 , 38 , 40 The subsequent release of these proinflammatory cytokines can lead to increased activation of the HPA axis. As a reactive oxygen species, long-term O 3 exposure can cause oxidative stress, leading to continued neuroinflammation, 10 , 41 , 42 thus increasing proinflammatory cytokine levels.…”

Section: Discussionmentioning

confidence: 99%

Association of Antepartum and Postpartum Air Pollution Exposure With Postpartum Depression in Southern California

Sun,

Headon,

Jiao

et al. 2023

JAMA Netw Open

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ImportanceWomen are especially vulnerable to mental health matters post partum because of biological, emotional, and social changes during this period. However, epidemiologic evidence of an association between air pollution exposure and postpartum depression (PPD) is limited.ObjectiveTo examine the associations between antepartum and postpartum maternal air pollution exposure and PPD.Design, Setting, and ParticipantsThis retrospective cohort study used data from Kaiser Permanente Southern California (KPSC) electronic health records and included women who had singleton live births at KPSC facilities between January 1, 2008, and December 31, 2016. Data were analyzed between January 1 and May 10, 2023.ExposuresAmbient air pollution exposures were assessed based on maternal residential addresses using monthly averages of particulate matter less than or equal to 2.5 μm (PM2.5), particulate matter less than or equal to 10 μm (PM10), nitrogen dioxide (NO2), and ozone (O3) from spatial interpolation of monitoring station measurements. Constituents of PM2.5 (sulfate, nitrate, ammonium, organic matter, and black carbon) were obtained from fine-resolution geoscience-derived models based on satellite, ground-based monitor, and chemical transport modeling data.Main Outcomes and MeasuresParticipants with an Edinburgh Postnatal Depression Scale score of 10 or higher during the 6 months after giving birth were referred to a clinical interview for further assessment and diagnosis. Ascertainment of PPD was defined using a combination of diagnostic codes and prescription medications.ResultsThe study included 340 679 participants (mean [SD] age, 30.05 [5.81] years), with 25 674 having PPD (7.54%). Increased risks for PPD were observed to be associated with per-IQR increases in antepartum and postpartum exposures to O3 (adjusted odds ratio [AOR], 1.09; 95% CI, 1.06-1.12), PM10 (AOR, 1.02; 95% CI, 1.00-1.04), and PM2.5 (AOR, 1.02; 95% CI, 1. 00-1.03) but not with NO2; PPD risks were mainly associated with PM2.5 organic matter and black carbon. Overall, a higher risk of PPD was associated with O3 during the entire pregnancy and postpartum periods and with PM exposure during the late pregnancy and postpartum periods.Conclusions and RelevanceThe study findings suggest that long-term exposure to antepartum and postpartum air pollution was associated with higher PPD risks. Identifying the modifiable environmental risk factors and developing interventions are important public health issues to improve maternal mental health and alleviate the disease burden of PPD.

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“…The present ndings, expand the association between temperature, air pollutants and aggression across species to also include dogs. It is notable that in rodents, exposure to ozone, heat stress, and their combination induces cognitive decline and neuroin ammation 52 . The link between ozone and aggression awaits veri cation such as by randomized double blinded exposure experiments in animals or possibly humans.…”

Section: Discussionmentioning

confidence: 99%

The risk of being bitten by a dog is higher on hot, sunny, and smoggy days

Dey

Zanobetti

Linnman

2022

Preprint

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Humans commit more violent crimes when temperature and air pollution is higher. Here, we investigate if also the day-to-day rates of dogs biting humans is influenced by environmental factors. 69,525 reports of dogs biting humans, sourced from public records on animal control requests and from ER records, were analyzed. The impact of temperature and air pollutants were evaluated with a zero-inflated Poisson generalized additive model, while controlling for regional and calendar effects. Exposure-response curves were used to assess the association between outcome and major exposure variables. We find that the rates of dogs biting humans increases with increasing temperature and ozone, but not PM2.5 exposure. We also observed that higher UV irradiation levels were related to higher rats of dog bites. We conclude that dogs, or the interactions between humans and dogs, are more hostile on hot, sunny, and smoggy days, indicating that the societal burden of extreme heat and air pollution also includes the costs of animal aggression.

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Combined exposure of heat stress and ozone enhanced cognitive impairment via neuroinflammation and blood brain barrier disruption in male rats

Cited by 15 publications

References 58 publications

The Effects of Polyphenol Supplementation on BDNF, Cytokines and Cognition in Trained Male Cyclists following Acute Ozone Exposure during High-Intensity Cycling

The Effects of Polyphenol Supplementation on BDNF, Cytokines and Cognition in Trained Male Cyclists following Acute Ozone Exposure during High-Intensity Cycling

Association of Antepartum and Postpartum Air Pollution Exposure With Postpartum Depression in Southern California

The risk of being bitten by a dog is higher on hot, sunny, and smoggy days

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