Combined exercise training reduces climacteric symptoms without the additive effects of isoflavone supplementation: A clinical, controlled, randomised, double-blind study

Dechichi, Juliene Gonçalves Costa; Giolo, Jéssica Sanjulião; Mariano, Igor Moraes; Batista, Jaqueline Pontes; Ribeiro, Ana Luiza Amaral; Souza, Tállita Cristina Ferreira de; Oliveira, Erick P. de; Resende, Ana Paula Magalhães; Puga, Guilherme Morais

doi:10.1177/0260106017727359

Cited by 14 publications

(11 citation statements)

References 24 publications

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“…Several trial studies also showed that isoflavone supplementation alleviated insomnia or sleep disorders among climacteric women [ 28 , 29 , 30 , 31 ]. However, other trial studies of isoflavone supplementation in climacteric women or androgen-deprived males found no significant improvement in insomnia or sleep quality [ 32 , 33 , 34 ]. Meanwhile, another randomized, placebo-controlled, double-blinded trial over six months performed on climacteric women indicated that insomnia was more frequent in the isoflavone supplementation group [ 35 ], and the longitudinal study reported that soy milk (one of the main food sources for isoflavone intake in the study) was positively related to falling asleep in the daytime among males [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, several trial studies have explored the relationship between total isoflavone supplementation and sleep in climacteric women or androgen-deprived prostate cancer patients, with mixed findings, including improvement of sleep problems [ 28 , 29 , 30 , 31 ], no significant association [ 32 , 33 , 34 ], and even insomnia aggravation [ 35 ]. Only two observational studies have evaluated the association of total isoflavone consumption with sleep status among general adults and results showed that total isoflavone consumption was positively related to sleep quality and optimal sleep duration in Japanese adults and inversely associated with long sleep duration in Chinese adults [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

et al. 2020

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Current evidence on the relationship of phytoestrogens with sleep is limited and contradictory. In particular, studies on individual phytoestrogens and sleep have not been reported. Thus, this study aimed to appraise the associations of individual phytoestrogens with sleep disorders and sleep duration. This cross-sectional study comprising 4830 adults utilized data from the National Health and Nutrition Examination Survey 2005–2010. Phytoestrogens were tested in urine specimens. Sleep disorders and sleep duration were based on a self-reported doctor’s diagnosis and usual sleep duration. The main analyses utilized logistic and multinomial logistic regression models and a restricted cubic spline. In the fully adjusted model, compared with tertile 1 (lowest), the odds ratios (95% confidence intervals (CIs)) of sleep disorders for the highest tertile of urinary concentrations of enterolactone, enterodiol, and O-desmethylangolensin were 0.64 (0.41–1.00), 1.54 (1.07–2.21), and 1.89 (1.26–2.85), respectively. Linear inverse, approximatively linear positive, and inverted L-shaped concentration–response relationships were found between enterolactone, enterodiol, and O-desmethylangolensin and sleep disorders, respectively. Compared with normal sleep (7–8 h/night), the relative risk ratio (RRR) (95% CI) of very short sleep for enterolactone was 0.56 (0.36–0.86), and the RRR (95% CI) of long sleep risk for genistein was 0.62 (0.39–0.99). Furthermore, negative associations of genistein with sleep disorders and enterolactone with long sleep risk, as well as positive associations of enterodiol with both long and very short sleep, were observed in the stratified analysis by age or gender. Finally, a notable finding was that urinary O-desmethylangolensin concentration was positively related to sleep disorders in both females aged 40–59 years and non-Hispanic Whites but inversely associated with sleep disorders in both females aged 60 years or over and other Hispanics. Our findings suggested that enterolactone and genistein might be beneficial for preventing sleep disorders or non-normal sleep duration among adults, and enterodiol might be adverse toward this goal. However, the association of O-desmethylangolensin with sleep disorders might be discrepant in different races and females of different ages.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

et al. 2020

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“…As a possible limitation, we report that there is no group without exercise as an intervention, no control of antihypertensive drug classes and doses, and the small sample size that could lead to type 2 error. Finally, we reiterate the importance of physical exercises after menopause regardless of the existence of hypertension, since, besides autonomic control alterations, they can generate improvements in blood pressure 23,32,33 , lipid profile 15 , endothelial function 34 , oxidative profile 35 , climacteric simptoms 36 , and general cardiovascular health 33,37 .…”

Section: Discussionmentioning

confidence: 90%

Effect of combined exercise training on heart rate variability in normotensive and hypertensive postmenopausal women

Mariano

Freitas

Batista

et al. 2021

Motriz: rev. educ. fis.

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This study aimed to verify and compare the effects of 10 weeks of combined exercise training on the heart rate variability of normotensive (NT) and hypertensive (HT) postmenopausal women. Methods: This is a quasiexperimental controlled clinical trial. Therefore, 14 HT and 12 NT postmenopausal women completed 10 weeks of combined exercise training. The exercise protocol consisted of 45 min of exercise, performed 3 times a week, consisting of 5 min of warm-up, 20 min of resistance exercise, and 20 min of aerobic exercise. Heart rate variability assessments were performed before and after the end of physical training. Results: Heart rate variability was assessed pre-and post-training periods.

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“…As far as menopause-specific QOL is concerned, both aerobic and resistance training, whether alone or together with nutritional supplements or educational initiatives, have been shown to improve climacteric symptoms in postmenopausal women [47,48]. In addition, such exercises alone may positively affect the impact of menopausal symptoms on QOL, as well as on psychological health and depression [49].…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Exercise on Sexual Function and Quality of Sexual Life Related to Menopausal Symptoms in Peri- and Postmenopausal Women: A Systematic Review

Carcelén-Fraile

Aibar-Almazán

Martínez‐Amat

et al. 2020

IJERPH

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During the menopausal period, sexual dysfunction is associated with the development or worsening of psychological conditions, causing deterioration in women’s mental health and quality of life. This systematic review aims to investigate the effects of different exercise programs on sexual function and quality of sexual life related to menopausal symptoms. With this purpose, a systematic literature search was conducted in PubMed, CINAHL, Scopus, Web of Science, and Cochrane Plus. A total of 1787 articles were identified in the initial search and 11 prospective studies (including 8 randomized controlled trials) were finally included. The most commonly recommended training programs are based on exercising pelvic floor muscles, as they seem to have the largest impact on sexual function. Mind–body disciplines also helped in managing menopausal symptoms. However, as far as the most traditional programs were concerned, aerobic exercises showed inconsistent results and resistance training did not seem to convey any benefits. Although positive effects have been found, evidence supporting physical exercise as a strategy to improve sexual function and quality of sexual life related to menopausal symptoms is limited, and further studies on this topic are needed.

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Combined exercise training reduces climacteric symptoms without the additive effects of isoflavone supplementation: A clinical, controlled, randomised, double-blind study

Abstract: A period of 10 weeks of combined training was effective in improving climacteric symptoms in post-menopausal women. However, isoflavone supplementation did not promote additional effects in improving symptoms.

Cited by 14 publications

References 24 publications

Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

Effect of combined exercise training on heart rate variability in normotensive and hypertensive postmenopausal women

Effects of Physical Exercise on Sexual Function and Quality of Sexual Life Related to Menopausal Symptoms in Peri- and Postmenopausal Women: A Systematic Review

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