Combined evaluation of preoperative FDG uptake on PET, ground-glass opacity area on CT, and serum CEA level: identification of both low and high risk of recurrence in patients with resected T1 lung adenocarcinoma

Higashi, Kõtarõ; Sakuma, Tsutomu; Ito, Kengo; Niho, Seiji; Ueda, Yoshimichi; Kobayashi, Takeshi; Sekiguchi, Ryuzo; Takahashi, Tomoko; Kato, Takashi; Tonami, Hisao

doi:10.1007/s00259-008-0961-4

Cited by 17 publications

(13 citation statements)

References 23 publications

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“…Using the optimal cut-off value identified in our study (>2.12 ng/mL), we found that serum CEA level was associated not only with IAC, but also with poor overall survival in T1 lung adenocarcinoma patients [11, 35]. Several studies have shown a correlation between high preoperative serum CEA levels and poor survival after lung cancer resection, which is consistent with our results [7, 11, 36]. …”

Section: Discussionsupporting

confidence: 91%

“…However, the optimal cut-off value for serum CEA level varies in the literature [7, 9]. Using the optimal cut-off value identified in our study (>2.12 ng/mL), we found that serum CEA level was associated not only with IAC, but also with poor overall survival in T1 lung adenocarcinoma patients [11, 35].…”

Section: Discussionmentioning

confidence: 57%

“…However, because of the high frequency of lymph node involvement, use of this procedure is still controversial. Moreover, tumours <3 cm with both GGO areas and solid areas are often aggressive and invasive [7]. The lung adenocarcinoma subtypes have distinct GGO patterns [8] and thus can be readily identified via imaging; identification of the subtype is essential for selecting the appropriate surgical procedure for patients with small-sized lung cancers.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

et al. 2016

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Aims. Identification of factors that can predict the subtypes of lung adenocarcinoma preoperatively is important for selecting the appropriate surgical procedure and for predicting postoperative survival. Methods. We retrospectively evaluated 87 patients with lung adenocarcinomas ≤30 mm. Results. Preoperative radiological findings, serum CEA level, serum microRNA-183 (miR-183) level, and tumour size differed significantly between patients with adenocarcinoma in situ (AIS) or minimally invasive adenocarcinoma (MIA) and those with invasive adenocarcinoma (IAC). Receiver operating characteristic curves and univariate analysis revealed that patients who were older than 57 years or had a pure solid nodule or a tumour with mixed ground-glass opacity (mGGO), a tumour >11 mm, a serum CEA level >2.12 ng/mL, or a serum miR-183 level >1.233 (2−ΔΔCt) were more likely to be diagnosed with IAC than with AIS or MIA. The combination of all five factors had an area under the curve of 0.946, with a sensitivity of 89.13% and a specificity of 95.12%. Moreover, patients with a cut-off value >0.499 for the five-factor combination had poor overall survival. Conclusions. The five-factor combination enables clinicians to distinguish AIS or MIA from IAC, thereby aiding in selecting the appropriate treatment, and to predict the prognosis of lung adenocarcinoma patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

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Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

et al. 2016

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“…However, solid lung tumors such as squamous cell carcinoma, and large/small cell carcinoma are often difficult to diagnose when the tumor has a small diameter without gradualgrowth characteristics, as it may be difficult to discriminate these masses from inflammatory lung nodules [33,34]. Given that elevated serum CEA was found to be a prognostic factor for LC, the combination of CT and serum CEA assays for LC screening may prove beneficial [35,36]. It must be noted however that the serum CEA levels in early stage LC are usually within the normal range.…”

Section: Discussionmentioning

confidence: 96%

Different efficacy of CT screening for lung cancer according to histological type: Analysis of Japanese-smoker cases detected using a low-dose CT screen

et al. 2011

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“…If cancer is found at surgery, yearly surveillance should be continued for at least 3 years to assess for the development of new cancers. As with single PSNs that are 810 mm, a PET scan should be done before surgery in order to optimize pre-operative assessment [25] .…”

Section: Recommendationmentioning

confidence: 99%

Incidental, subsolid pulmonary nodules at CT: etiology and management

Seidelman¹,

Quint²

2013

Cancer Imaging

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Pulmonary nodules, both solid and subsolid, are common incidental findings on computed tomography (CT) studies. Subsolid nodules (SSNs) may be further classified as either pure ground-glass nodules or part-solid nodules. The differential diagnosis for an SSN is broad, including infection, organizing pneumonia, inflammation, hemorrhage, focal fibrosis, and neoplasm. Adenocarcinomas of the lung are currently the most common type of lung cancer, representing 3035% of all primary lung tumors, and the subtype of bronchioloalveolar cell carcinoma (BAC) commonly presents as an SSN. In 2011, a new classification system for lung adenocarcinomas was proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society. An important feature of the new system is the relinquishment of the term BAC in favor of more specific histologic subtypes. It has been reported that these subtypes are associated with characteristic CT findings. This article reviews the new classification system of lung adenocarcinomas, discusses and illustrates the associated CT findings, and outlines the current recommendations for further diagnosis, treatment, and follow-up of SSNs based on computed tomography findings.

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Combined evaluation of preoperative FDG uptake on PET, ground-glass opacity area on CT, and serum CEA level: identification of both low and high risk of recurrence in patients with resected T1 lung adenocarcinoma

Abstract: Combined evaluation of preoperative FDG uptake, GGO, and serum CEA level may enable patients with T1 lung adenocarcinoma at low risk and at high risk of postoperative recurrence to be identified.

Cited by 17 publications

References 23 publications

Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

Different efficacy of CT screening for lung cancer according to histological type: Analysis of Japanese-smoker cases detected using a low-dose CT screen

Incidental, subsolid pulmonary nodules at CT: etiology and management

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