Combined effects of solvents on the rat's auditory system: Styrene and trichloroethylene

Rebert, Charles S.; Boyes, William K.; Pryor, Gordon T.; Svensgaard, D J; Kassay, K M; Gr, Gordon; Shinsky, N

doi:10.1016/0167-8760(93)90083-2

Cited by 35 publications

(18 citation statements)

References 18 publications

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“…Our analysis provided evidence that when the number of solvents exceeded 5, the risk estimate was 4.22 times higher. Several animal studies have confirmed that exposure to combinations of some solvents (mixtures of solvents) will contribute to greater hearing loss than it was found in single-solvent exposures [49][50][51][52][53]. The human studies have also confirmed such results [35].…”

Section: Ijomeh 2017;30(4)supporting

confidence: 68%

The risk of hearing loss associated with occupational exposure to organic solvents mixture with and without concurrent noise exposure: A systematic review and meta-analysis

Hormozi

Ansari‐Moghaddam

Mirzaei

et al. 2017

Int J Occup Med Environ Health

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This study is a meta-analysis of the previous epidemiological studies which investigated the quantitative estimates of the association between independent or combined exposure to noise and mixed organic solvents and hearing loss until October 2014. Overall, 15 studies with information on 7530 individuals (6% female) were included. Having assessed -by puretone audiometry -the adjusted odds ratio estimates for the association between solvents mixture exposure and the risk of developing hearing loss stood at 2.05 (95% confidence interval (CI): 1.44-2.9). Similarly, for subjects who were concurrently exposed to noise and solvents mixture, an OR of 2.95 (95% CI: 2.1-4.17) was obtained. There was some evidence of heterogeneity within each of the 2 exposure groups (p heterogeneity < 0.001). This heterogeneity was not explained by differences in strength of effect between duration of exposure, the number of solvent and exposure index in subgroups of solvents mixture exposure. Based on the available data, our analysis has provided the evidence of increased risk of developing hearing loss for workers exposed to organic solvents even at quite low concentration. Moreover, if such exposure is accompanied by noise, it will exacerbate the extent of hearing loss. Int J Occup Med Environ Health 2017;30(4):521-535

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Section: Ijomeh 2017;30(4)supporting

confidence: 68%

The risk of hearing loss associated with occupational exposure to organic solvents mixture with and without concurrent noise exposure: A systematic review and meta-analysis

Hormozi

Ansari‐Moghaddam

Mirzaei

et al. 2017

Int J Occup Med Environ Health

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“…Taken together, these data suggest that TCE-induced ototoxicity may be limited to situations of solvent abuse or settings where occupational standards are exceeded for extended periods of time. Importantly, one should note that ototoxicity following exposure to multiple solvents is additive (Rebert et al, 1993(Rebert et al, , 1995 and combined exposures to noise and solvents may be additive or synergistic (for recent reviews see Morata et al, 1993;1994;Johnson and Nyle"n, 1995).…”

Section: -Weekmentioning

confidence: 99%

“…Evidence for the ototoxicity of trichloroethylene has been demonstrated using animal models (Rebert et al, 1991(Rebert et al, , 1993Crofton and Zhao, 1993;Jaspers et al, 1993;Crofton et al, 1994). The use of high concentrations in animal experiments have hampered calculation of noncancer risk estimates for the ototoxicity of long-duration, low-concentration exposures.…”

mentioning

confidence: 99%

The Ototoxicity of Trichloroethylene: Extrapolation and Relevance of High-Concentration, Short-Duration Animal Exposure Data

Crofton

Zhao

1997

Toxicol Sci

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Inhalation exposure to high concentrations of 1,1,2-trichloroethylene (TCE) has been shown to damage hearing in the mid-frequency range in the rat The present study directly evaluated the adequacy of high-concentration, short-term exposures to TCE for predicting the neurotoxicity produced by longer duration exposures. Adult male Long-Evans rats (n = 10-12 per group) were exposed to TCE via inhalation (whole body) in 1-m 3 stainless steel flow-through chambers for 6 hr/day, 5 days/week. The following exposures were used: 1 day (4000-8000 ppm), 1 week (1000-4000 ppm), 4 weeks (800-3200 ppm), and 13 weeks (800-3200 ppm). Air-only exposed animals served as controls. Auditory thresholds were determined for a 16-kHz tone 3-5 weeks after exposure using reflex modification audiometry. Results replicated previous findings of a hearing loss at 16 kHz for all exposure durations. The dB15 concentrations (concentration that increases thresholds by 15 dB) for 16-kHz thresholds were 6218, 2992, 2592, and 2160 ppm for the 1-day, 1-week, 4-week and 13-week exposures, respectively. These data demonstrate that the ototoxicity of TCE was less than that predicted by a strict concentration x time relationship. These data also demonstrate that simple models of extrapolation (i.e., C X r = k, Habeas Law) overestimate the potency of TCE when extrapolating from short-duration to longer-duration exposures. Furthermore, these data suggest that, relative to ambient or occupational exposures, the ototoxicity of TCE in the rat is a high-concentration effect c 1997 society' of To 1,1,2-Trichloroethylene (TCE) is a volatile organic solvent with widespread human exposure. TCE is used primarily as a metal parts degreaser, with production volume for ' This manuscript has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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“…In addition, another reactive metabolite, 7, 8 oxide styrene was documented by genetic toxicology and conjugation with glutathione to lead to damage to the cellular structure. 14,15) In contrast, to our knowledge, although evoked potentials, in particular, brainstem auditory-evoked potentials (EAEPs) has been examined in humans and experimental animals exposed to organic solvents, including styrene in previous studies, 16,17) no report has pointed out any changes in the central nervous system caused by styrene exposure using middle latency auditory-evoked potentials (MAEPs). Analysis of MAEPs as a new and relatively noninvasive technique for evaluating the function of the central nervous system has been widely used in clinical and experimental studies.…”

Section: Introductionmentioning

confidence: 87%

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

Wang

Saito

Hosokawa

et al. 2001

JOURNAL OF HEALTH SCIENCE

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Effects of styrene exposure on middle latency auditory-evoked potentials (MAEPs), which reflect the central auditory function, were investigated. As significant delay in latencies of No, Po, Na, and Pa components and increases in the peak to peak intervals of MAEPs, but not amplitudes, were observed in a dose-dependent manner. The present and our previous studies demonstrate that electrophysiological alterations occur before neuronal cell damage induced by styrene exposure. The present results suggested that styrene has a marked effect on the processing of auditory information related to MAEPs.

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Combined effects of solvents on the rat's auditory system: Styrene and trichloroethylene

Cited by 35 publications

References 18 publications

The risk of hearing loss associated with occupational exposure to organic solvents mixture with and without concurrent noise exposure: A systematic review and meta-analysis

The risk of hearing loss associated with occupational exposure to organic solvents mixture with and without concurrent noise exposure: A systematic review and meta-analysis

The Ototoxicity of Trichloroethylene: Extrapolation and Relevance of High-Concentration, Short-Duration Animal Exposure Data

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

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