Combined effects of selected insecticides on humoral immune response in mice

Flipo, Denis; Bernier, Jacques; Girard, Denis; Krzystyniak, Krzysztof; Fournier, Michel

doi:10.1016/0192-0561(92)90071-r

Cited by 47 publications

(27 citation statements)

References 16 publications

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“…PBMC suspension (10 6 cells) in RPMI 1640 medium with no supplement or with 1% sodium azide were incubated at 37°C and at 4°C (negative controls), respectively, for 30 min with 1.75 µm fluorescent microspheres (Polyscience, Warrington, Pennsylvania, USA) at a cell/microspheres ratio of 1:100 as previously described [12]. The percentages of cells with 2 or more engulfed microspheres and the mean fluorescence intensity which is indicative of the number of engulfed microspheres (one microsphere equals 10 fluorescence units) per cell were determined by flow cytometry [29].…”

Section: Phagocytosismentioning

confidence: 99%

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

et al. 2000

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-Eight calves between 16 and 18 weeks of age that were seronegative to bovine viral diarrhea virus (BVDV), bovine leucosis virus and bovine immunodeficiency-like virus were infected (day 0) intranasally with the type 2 noncytopathogenic Canadian 24515 field isolate of BVDV in order to evaluate the effect of BVDV infection on certain clinical, hematological and immunological parameters. All virus-exposed animals developed fever and showed a significant (P < 0.05, 0.01 or 0.001) drop in the number of circulating leucocytes (neutrophils, lymphocytes and monocytes) by day 3 or 5 post-exposure (PE), which continued to the end of the experiment at day 12 PE. BVDV was consistently isolated from the peripheral blood buffy coat cells from day 5 PE, and also from selected tissues (spleen, thymus, mesenteric and submaxillary lymph nodes, small intestine, lungs and thyroid gland) that were collected at the time of euthanasia of the animals at day 12 PE. Diminished significant (P < 0.05) percentages of peripheral blood mononuclear cells (PBMCs) expressing at their surface either B7 and MHC II molecules were observed in virus-exposed calves at days 7, 10 and/or 12 PE, when compared to virus-nonexposed control calves (n = 5). However, no changes in the percentages of PBMCs expressing either B4 or MHC I molecules were observed throughout the experiment. Finally, a significant (P < 0.05 or 0.01) enhanced phagocytic capability of the PBMCs, as analyzed by flow cytometry, was observed in virus-exposed animals at days 3, 5, 7, 10 and 12 PE, when compared to control calves. These results demonstrated the virulence of the 24515 isolate of BVDV in 4 to 4.5 month-old calves, and suggest that type 2 BVDV infection in calves is associated with dysregulation of certain immunological functions. bovine viral diarrhea virus type 2 / clinical response / immunomodulation Vet. Res. 31 (2000) 215-227 215

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Section: Phagocytosismentioning

confidence: 99%

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

et al. 2000

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“…Also, this study reported that a single acute exposure to carbofuran suppressed humoral immune responses in mice. Transient but marked inhibition of plaque forming cell (PFC) response was observed at day 10 after exposure to carbofuran (0.6 mg/kg body weight) 5 . In addition, carbofuran exposure causes suppression of bone marrow cellularity and decreased granulocyte-macrophage progenitor cells in C57BL/6 mice with doses as low as 0.3mg/kg/day for 7 days 6 .Carbofuran application inhibits also splenic T cell proliferation and causes a dose-related decrease in thymic cellularity 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to carbofuran markedly suppressed the humoral immune response in mice. This chemical exposure resulted in a decreased plasma cell count in popliteal lymphoid nodes, and a reduction of germinal centers in the spleen 5 . Also, this study reported that a single acute exposure to carbofuran suppressed humoral immune responses in mice.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

Dhouib¹,

Abdeladhim²,

Lasram³

et al. 2014

IOSRJESTFT

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“…Previous studies suggest that juveniles may be at higher risk of having adverse health effects from pesticide exposure because of rapid maturation of organs and functional systems, such as the neurologic and immunologic systems (Hermanowitz and Kossman, 1984;Thomas and House, 1989;Flipo et al, 1992;Thrasher et al, 1993;Rodgers, 1995;Acquavella et al, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

A pilot study of global positioning system/geographical information system measurement of residential proximity to agricultural fields and urinary organophosphate metabolite concentrations in toddlers

Royster

Hilborn

Barr

et al. 2002

J Expo Sci Environ Epidemiol

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This pilot study enrolled 20 children between the ages of 11 and 17 months in Imperial County, California to assess children's pesticide exposure and residential proximity to agricultural fields. We compared parental self -report of residential proximity to agricultural fields to measurements using global positioning system / geographical information system ( GPS / GIS ) technology, and we assessed the relationship between residential proximity to agricultural fields and a biomarker of organophosphate ( OP ) pesticide exposure. Questionnaires were administered twice, 4 weeks apart, to determine self -reported residential proximity to agricultural fields. Urine samples were collected at each contact to measure OP metabolites. Actual residential proximity to the closest agricultural field and number of fields was within 1 mile to the west were measured using GPS / GIS. Self -report of living proximity to agricultural fields agreed with GPS / GIS measurement 75% of the time during the initial interview, compared to 66% agreement during the second interview. Presence of urinary metabolites suggests that OP exposure was ubiquitous: creatinine -adjusted total urinary dimethyl values ranged from 1.60 to 516.00 g / g creatinine, and total diethyl ranged from 2.70 to 134.84 g / g creatinine. No association was found between urinary OP metabolites and residential to field proximity. These results suggest that initial self -report of living proximity to agricultural fields may be more accurate than follow -up self -report. Limitations in this pilot study prevent determination of whether self -report is an accurate measure of proximity.

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Combined effects of selected insecticides on humoral immune response in mice

Cited by 47 publications

References 16 publications

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

A pilot study of global positioning system/geographical information system measurement of residential proximity to agricultural fields and urinary organophosphate metabolite concentrations in toddlers

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