Combined effects of probiotic and chondroprotector during osteoarthritis in rats

Korotkyi, Oleksandr; Dvorshchenko, K.; Falalyeyeva, Tetyana; Sulaieva, Oksana; Kobyliak, Nazarii; Abenavoli, Ludovico; Fagoonee, Sharmila; Pellicano, Rinaldo; Li, Ostapchenko

doi:10.23736/s0031-0808.20.03841-0

Cited by 20 publications

(14 citation statements)

References 46 publications

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“…Turmeric (or curcumin) is an extract of turmeric, a yellow spice, and a member of the Zingiberaceae family. Both turmeric and ginger have roots in Ayurvedic and Chinese medicine [ 25 ], and turmeric exhibits anti-inflammatory effects through cyclooxygenase-2, inhibition of prostaglandins, and leukotoxins. There is a wide variation in daily doses from 180 to 2000 mg, which makes direct comparison problematic.…”

Section: Resultsmentioning

confidence: 99%

“…Collagen-containing raw materials are mainly connective tissue, consisting of cells, intercellular substance and collagen fibers, in addition, it contains a small amount of elastin and reticulin fibers, as well as passing blood vessels. Connective tissue provides strength to the external and internal structures of the animal organism, it is rich in valuable mineral substances, contains amino acids, physiologically active substances in sufficient quantities [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…It is known that HA metabolites under conditions of a pronounced inflammatory process possess not anti- but pro-inflammatory activity and can cause exacerbation [ 33 ]. The studies of leading scientists [ 25 ] for the treatment of OA present the experience of using biologically active additives obtained by enzymatic hydrolysis of the cartilaginous tissue of aquatic organisms. Biopreparations from various types of aquatic organisms are standardized for hexosamine content (at least 2%), contain chondroitin sulfate (6%), and collagen (16–24%) and are a complex of proteoglycans with high, medium, and low molecular weight.…”

Section: Resultsmentioning

confidence: 99%

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Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue

et al. 2020

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Osteoarthritis is one of the most common diseases of the connective tissue of the elderly. It was found that most epidemiological studies used the Kellgren and Lawrence system for classification of osteoarthritis, which indicates one of the 5 degrees (0–4) of osteoarthritis in various joints according to the radiographic atlas. It has been proven that chondroprotectors are represented by the following active substances: chondroitin sulfate, glucosamine sulfate or hydrochloride, hyaluronic acid, glycosaminoglycans, extraction preparations from animal or plant raw materials. The sources of raw materials for the manufacture of combined chondroprotectors are known, methods for their preparation and use are described. The main drugs on the chondroprotective market are presented. The effectiveness of their use for the treatment of osteoarthritis has been proven. It was found that preparations containing chondroitin sulfate have anti-inflammatory activity, affecting mainly the cellular component of inflammation, stimulate the synthesis of hyaluronic acid and proteoglycans. Methods of treating osteoarthritis using cell therapy (the use of readily available, highly proliferative, and multipotent mesenchymal stromal cells) are presented.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue

et al. 2020

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“…The term human microbiota is referred to the rich microbial community, consisting of more than 10 14 microorganisms, that colonizes the GI tract [24]. The perturbation of this ecosystem as well as of mucosal integrity allows bacterial translocation and plays a key role in the development of GI and systemic diseases [25][26][27]. Molecules produced by microbiota components can modify intestinal motility, and, at the same time, motility influences microbiota composition.…”

Section: Functional Dyspepsiamentioning

confidence: 99%

Management of Dyspepsia and Gastroparesis in Patients with Diabetes. A Clinical Point of View in the Year 2021

Bonetto

Gruden

Beccuti

et al. 2021

JCM

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Diabetes mellitus is a widespread disease, and represents an important public health burden worldwide. Together with cardiovascular, renal and neurological complications, many patients with diabetes present with gastrointestinal symptoms, which configure the so-called diabetic enteropathy. In this review, we will focus on upper gastrointestinal symptoms in patients with diabetes, with particular attention to dyspepsia and diabetic gastroparesis (DG). These two clinical entities share similar pathogenetic mechanisms, which include autonomic neuropathy, alterations in enteric nervous system and histological abnormalities, such as interstitial cells of Cajal depletion. Moreover, the differential diagnosis may be challenging because of overlapping clinical features. Delayed gastric emptying should be documented to differentiate between DG and dyspepsia and it can be assessed through radioactive or non-radioactive methods. The clinical management of dyspepsia includes a wide range of different approaches, above all Helicobacter pylori test and treat. As regards DG treatment, a central role is played by dietary modification and glucose control and the first-line pharmacological therapy is represented by the use of prokinetics. A minority of patients with DG refractory to medical treatment may require more invasive therapeutic approaches, including supplemental nutrition, gastric electric stimulation, pyloromyotomy and gastrectomy.

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“…Understanding the links between the state of intestinal microflora and the development of the inflammatory processes may help to predict destructive processes in the joint on the early stage of OA. The progression of inflammation in the joints is intensified by free radical processes, that lead to damage of synovial cells, destruction of cartilage, erosion of bones, and joint surfaces [11,12]. Matrix metalloproteinases (MMPs) affect the metabolism of extracellular matrix components and concerned as markers of joint tissue destruction [13,14].…”

mentioning

confidence: 99%

Oxidative/antioxidant balance and matrix metalloproteinases level in the knee cartilage of rats under experimental osteoarthritis and probiotic administration

Korotkyi¹,

Dvorshchenko²,

Коt³

2020

Ukr.Biochem.J

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The aim of this work was to investigate the effect of the poly-strain probiotic on oxidative-antioxidant balance and the level of matrix metalloproteinases (MMPs) in rat knee cartilage under experimental osteoarthritis. Osteoarthritis was induced by a single injection of monoiodoacetate into the knee joint of rats. Probiotic was administered daily for 14 days. Knee cartilages homogenate was used to evaluate the content of reactive oxygen species (superoxide anion and hydrogen peroxide), products of lipids peroxidation (diene conjugates, TBA-active compound, Shiff bases), to determine superoxide dismutase and catalase activity and activity of glutathione-dependent antioxidant enzymes, the level of reduced and oxidized glutathione. The level of MMPs -1, -2, -3, -8 expression was estimated by ELISA. Osteoarthritis was found to cause a significant increase in the reactive oxygen species level, lipid peroxidation products content, superoxide dismutase and catalase activity, level of all studied MMPs, and also depletion of glutathione-dependent antioxidant system and the decrease in the ratio between reduced and oxidized glutathione.The administration of the probiotic was followed by the tendency for the restoration of the parameters to the values of the control group. Thus, the administration of the probiotic to rats with osteoarthritis may be considered as an anti-inflammatory and antioxidant agent for further clinical trials. K e y w o r d s: osteoarthritis, probiotic, free radical processes, glutathione, matrix metalloproteinases.

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Combined effects of probiotic and chondroprotector during osteoarthritis in rats

Cited by 20 publications

References 46 publications

Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue

Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue

Management of Dyspepsia and Gastroparesis in Patients with Diabetes. A Clinical Point of View in the Year 2021

Oxidative/antioxidant balance and matrix metalloproteinases level in the knee cartilage of rats under experimental osteoarthritis and probiotic administration

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