Combined effect of PLGA and curcumin on wound healing activity

Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: Development, in-vitro appraisal and in-vivo studies

“…This might be due to inability of the drugs to penetrate skin efficiently or to be localized in the skin for prolonged effect. Therefore, they need longer time to give their therapeutic effect which was in agreement with previous studies that observed healing effect for Curc after 14 or 19 days (Chereddy et al, 2013;Gong et al, 2013;Kant et al, 2014) and for HA after 29 days (Medeiros et al, 1999). Hence, the novel self-assembled gel-core hyaluosomes might be a promising carrier for HA and Curc; accelerating the wound healing process with possibility of reducing scar formation.…”

Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds

“…[14] In our previous work, we have extensively studied the dual roles of PLGA in wound healing: a wound healing agent itself via lactate and it is able to hydrolytically degrade and release loaded drugs sustainably. [15,16] Moreover, PLGA nanoparticles (NP) have been proved to be efficient carriers for VEGF and can accelerate angiogenesis. [17] To our knowledge, PLGA and VEGF application in acute or diabetic wound healing and investigation of their combined effects have never been reported before.…”

“…[15,21] Briefly, 6-7 weeks old RjHan:NMRI (n=40) and 7-8 weeks old db/db (n=20) female mice (Janvier, BE) were randomly grouped. Leptin receptor deficient db/db mice were used for diabetic wound model.…”

“…The inclusion of controls (untreated, VEGF and PLGA NP) presents insights into the individual abilities and activities in wound healing and their comparative validation. From our previous works[15,16] and considering the molecular weight of PLGA polymer, 5 mg/wound dose was chosen for PLGA-VEGF NP and the controls were determined accordingly. The healing kinetics of both non-diabetic and diabetic wounds clearly showed that PLGA-VEGF NP treated mice exhibited a significant faster wound closure than the other groups.…”

A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-β_1–42-injected mice

“…The release medium (pH 5.0) was 25 mL of 0.9% NaCl solution containing 50% ethanol (95:5, v/v). 26 At different time points, 0.1 mL of samples was measured, and then the amount of drug loaded into POs and the in vitro cumulative release rate were calculated.…”