A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-&amp;beta;&lt;sub&gt;1&amp;ndash;42&lt;/sub&gt;-injected mice

Jia, Ting Ting; Sun, Zhi; Lu, Ying; Gao, Jie; Zou, Hao; Xie, Fang; Zhang, Guo Qing; Xu, Hao; Sun, Du Xin; Yuan, Yu; Zhong, Yan

doi:10.2147/ijn.s94622

Cited by 32 publications

(9 citation statements)

References 39 publications

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“…Based on the abovementioned data, some authors have proved the scavenging effects of curcumin, such as a glutathione concentration enhancer, thus preventing the lipid peroxidation [ 47 , 49 , 50 ]. So, indeed, we reached similar conclusions, regarding the antioxidant effect of curcumin, to these mentioned in the literature.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Reverses the Diazepam‐Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF‐κB Pathway in Brain

Sevastre-Berghian

Făgărăşan

Toma

et al. 2017

Oxidative Medicine and Cellular Longevity

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Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels. The ERK/NF-κB signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam-treated rats, were also analyzed. The animals were divided into 4 groups: control, carboxymethylcellulose (CMC) + CUR, CMC + DZP, and CUR + CMC + DZP. CUR (150 mg/kg b.w.) was orally administered for 28 days. DZP (2 mg/kg b.w.) was intraperitoneally administered 20 minutes before the behavioral tests (open field test, Y-maze, and elevated plus maze). CUR improved the spontaneous alternation behavior, decreased the oxidative stress levels, both in the blood and in the hippocampus, and downregulated the extracellular signal-regulated kinase (ERK 1/2)/nuclear transcription factor- (NF-) κB/pNF-κB pathway in the hippocampus and the iNOS expression in the hippocampus and frontal lobe of the DZP-treated rats. Histopathologically, no microscopic changes were found. The immunohistochemical signal of iNOS decreased in the DZP and CUR-treated group. Thus, our findings suggest that curcumin administration may improve the cognitive performance and may also have an antioxidant effect.

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Section: Discussionmentioning

confidence: 99%

Curcumin Reverses the Diazepam‐Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF‐κB Pathway in Brain

Sevastre-Berghian

Făgărăşan

Toma

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Jia and colleagues (2016) [96] studied curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal Aβ42 injected mice. Due to the impermeability of the blood-brain barrier and the nonselective distribution of drugs in the brain, the therapeutic access to intractable neurological disorders is challenging.…”

Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning

confidence: 99%

“…The curcumin-encapsulated Tf/Tet-1-POs provided neuroprotection and ameliorated cognitive dysfunction in intra-hippocampal Aβ42 injected mice. These results suggest that the dual brain-targeting POs are more capable of drug delivery to the brain that can be exploited as a multiple noninvasive vehicle for targeting therapeutics [96]. …”

Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning

confidence: 99%

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Reddy

Mańczak

Yin

et al. 2018

JAD

274

138

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The purpose of our article is to assess the current understanding of Indian spice ‘Curcumin’ against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural products, such as ginger, curcumin and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, anti-oxidant, anti-arthritis, pro-healing and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on amyloid-β and curcumin has revealed that curcumin prevents amyloid-β aggregation and crosses the blood brain barrier (BBB), reach brain cells and protect neurons from various toxic insults of aging and amyloid-β in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin’s bioavailability and urgent need for new formulation to increase its brain levels to treat patients with AD.

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“…Poly(ethylene glycol)- block -poly(D,L-lactic-co-glycolic acid) polymersomes were decorated with transferrin and Tet-1 peptides. [112] Tet-1 is a 12-amino acid peptide which has high affinity for GT1B receptors on neurons. These polymersomes were loaded with curcumin, a polyphenol which is found to promote the degradation of amyloid-β proteins in Alzheimer’s disease but is poorly soluble in water and poorly absorbed in the brain.…”

Section: Surface Activities Of Polymersomesmentioning

confidence: 99%

Engineering Polymersomes for Diagnostics and Therapy

Leong

Teo

Aakalu

et al. 2018

Adv Healthcare Materials

109

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Engineered polymer vesicles, termed as polymersomes, confer a flexibility to control their structure, properties, and functionality. Self-assembly of amphiphilic copolymers leads to vesicles consisting of a hydrophobic bilayer membrane and hydrophilic core, each of which is loaded with a wide array of small and large molecules of interests. As such, polymersomes are increasingly being studied as carriers of imaging probes and therapeutic drugs. Effective delivery of polymersomes necessitates careful design of polymersomes. Therefore, this review article discusses the design strategies of polymersomes developed for enhanced transport and efficacy of imaging probes and therapeutic drugs. In particular, the article focuses on overviewing technologies to regulate the size, structure, shape, surface activity, and stimuli- responsiveness of polymersomes and discussing the extent to which these properties and structure of polymersomes influence the efficacy of cargo molecules. Taken together with future considerations, this article will serve to improve the controllability of polymersome functions and accelerate the use of polymersomes in biomedical applications.

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A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-β<sub>1–42</sub>-injected mice

Cited by 32 publications

References 39 publications

Curcumin Reverses the Diazepam‐Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF‐κB Pathway in Brain

Curcumin Reverses the Diazepam‐Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF‐κB Pathway in Brain

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Engineering Polymersomes for Diagnostics and Therapy

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