Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction

Motiwala, Meha N.; Rangari, Vinod D.

doi:10.1016/j.synres.2015.04.001

Cited by 34 publications

(23 citation statements)

References 36 publications

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“…Furthermore, piperine has been found to enhance the sensitisation of HER2-overexpressing breast cancer cells to paclitaxel (Taxol ® ), a chemotherapy medication used to treat breast cancer (31,34). A synergistic effect has also been observed with Tamoxifen against breast cancer cells (35).…”

Section: Methodsmentioning

confidence: 99%

Chemoprevention of Breast Cancer With Vitamins and Micronutrients: A Concise Review

Mokbel

2019

In Vivo

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Section: Methodsmentioning

confidence: 99%

Chemoprevention of Breast Cancer With Vitamins and Micronutrients: A Concise Review

Mokbel

2019

In Vivo

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“…28 Combination therapy with chemotherapeutics may work in a synergistic or additive manner, lowering the therapeutic dosage of one agent and thereby reducing toxic effects. 5 Several chemotherapeutic drugs have been tested in combination with PIP, SFN, and TQ, as described below (the summarized mechanisms of action of the combinations are shown in Table 4 [8][9][10][11]16,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] ).…”

Section: Combination With Chemotherapeutic Drugsmentioning

confidence: 99%

“…), with other conventional therapies, including chemotherapy, hormone therapy, radiotherapy, tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), and microRNA (miRNA) therapy, and nanodelivery‐based combination therapy. PIP, a compound isolated from black and long pepper ( Piper nigrum L. and Piper longum L., respectively) has several physiological effects in the body . SFN is an isothiocyanate derived mainly from cruciferous vegetables such as broccoli sprouts and kale .…”

Section: Introductionmentioning

confidence: 99%

“…A study by Motiwala and Rangari found that the concomitant exposure of PIP plus paclitaxel for 24 hours in MCF‐7 breast cancer cells in vitro was superior to sequential exposure (PIP for 24 hours followed by paclitaxel for 24 hours). The combination index (CI) values for the concomitant exposure at the half maximal inhibitory concentration (IC 50 ) (0.58) demonstrated synergism and the CI at IC 70 (0.77) exhibited moderate synergism.…”

Section: Introductionmentioning

confidence: 99%

“…PIP, a compound isolated from black and long pepper (Piper nigrum L. and Piper longum L., respectively) has several physiological effects in the body. 8 SFN is an isothiocyanate derived mainly from cruciferous vegetables such as broccoli sprouts and kale. 9 Nigella sativa L. also is one of the important herbs, with the majority of its biological properties associated with the presence of TQ, the major active compound in the seeds of this plant.…”

Section: Introductionmentioning

confidence: 99%

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Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone

Aumeeruddy

Mahomoodally

2019

Cancer

117

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Despite the significant advances in screening methods for early diagnosis, breast cancer remains a global threat and continues to be the leading cancer diagnosed in women, requiring effective therapy. Currently, combination therapy has become the hallmark of breast cancer treatment due to the high incidence of tumor recurrence and disease progression after monotherapeutic treatments, including surgery, radiotherapy, endocrine therapy, and chemotherapy. Over the past decades, there has been considerable interest in studying the anticancer effect of bioactive phytochemicals from medicinal plants combined with these conventional therapies. The rationale for this type of therapy is to use combinations of drugs that work by different mechanisms, thereby decreasing the likelihood that cancer cells will develop resistance, and also reduce the therapeutic dose and toxicity of single treatments. Three agents have received great attention with regard to their anticancer properties: 1) piperine, a dietary phytochemical isolated from black pepper (Piper nigrum L.) and long pepper (Piper longum L.); 2) sulforaphane, an isothiocyanate mainly derived from cruciferous vegetables; and 3) thymoquinone, the active compound from black seed (Nigella sativa L.). This review focused on the combined effect of these 3 compounds on conventional cancer therapy with the objective of observing enhanced efficacy compared with single treatments. This review also highlights the importance of the nanoformulation of such bioactive phytochemicals that could enhance their bioavailability by providing an efficient targeted delivery system with a reduced systemic dose while resulting in a more efficient dosing at the target site.

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Bioactive interactions in food and natural extracts

Moco¹,

Barron²

2017

Nutrigenomics and Proteomics in Health and Disease

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Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction

Cited by 34 publications

References 36 publications

Chemoprevention of Breast Cancer With Vitamins and Micronutrients: A Concise Review

Chemoprevention of Breast Cancer With Vitamins and Micronutrients: A Concise Review

Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone

Bioactive interactions in food and natural extracts

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