Combined effect of cellulose nanocrystal and reduced graphene oxide into poly-lactic acid matrix nanocomposite as a scaffold and its anti-bacterial activity

Pal, Nidhi; Dubey, Poornima; Gopinath, P.; Pal, Kaushik

doi:10.1016/j.ijbiomac.2016.11.041

Cited by 111 publications

(51 citation statements)

References 39 publications

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“…Furthermore the in vitro cell based cytotoxicity assay showed negligible cytotoxicity of fibroblast cell line upon treatment with nanocomposite film. The fabricated nanocomposite films possess considerable potential in biomedical as well as in food packing applications . Furthermore, cellulose‐silver nanocomposite possess a high antibacterial activity against the E. coli and S. aureus and the nanocomposite can be used as a promising material for the application in the biomedical field .…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Amalraj¹,

Gopi²,

Thomas

et al. 2018

Macromolecular Symposia

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Nanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made various nanocomposite materials an intriguing prospect for different application in the biomedical, food, and nutraceutical industries. In this review, we have discussed and provided a summary of the recent researches in the utilization of cellulosic nanomaterials in applications related to food packaging, bone tissue engineering, wound dressing, drug delivery, and nutraceutical research area and industries.

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Section: Introductionmentioning

confidence: 99%

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Amalraj¹,

Gopi²,

Thomas

et al. 2018

Macromolecular Symposia

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“…GO/PLLA nanocomposites were also prepared in the form of electrospun fibers and 3D porous scaffolds. [150] PLLA Nanofibers GO/PCL/PLLA nanofibers were also prepared. [25,147] Although PCL and PLLA are immiscible, with the incorporation of GO, their miscibility could be improved.…”

Section: Pllamentioning

confidence: 99%

“…[150] Chen et al [22] prepared 3D printed biocompatible GO/polyurethane/PLLA nanocomposites were easily prepared. The nanocomposites had excellent mechanical properties, thermal stability, and NIH3T3 cell viability.…”

Section: Plla 3d Porous Scaffoldsmentioning

confidence: 99%

Graphene Oxide/Polymer‐Based Biomaterials

2017

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Since its discovery in 2004, derivatives of graphene have been developed and heavily investigated in the field of tissue engineering. Among the most extensively studied forms of graphene, graphene oxide (GO), and GO/ polymer-based nanocomposites have attracted great attention in various forms such as films, 3D porous scaffolds, electrospun mats, hydrogels, and nacre-like structures. In this review, the most actively investigated GO/ polymer nanocomposites are presented and discussed, these nanocomposites are based on chitosan, cellulose, starch, alginate, gellan gum, poly(vinyl alcohol) (PVA), poly(acrylamide), poly(e-caprolactone) (PCL), poly(lactic acid) (PLLA), poly(lactide-co-glycolide) (PLGA), gelatin, collagen, and silk fibroin (SF). The biological and mechanical performance of such nanocomposites are comprehensively scrutinized and ongoing research questions are addressed. The analysis of the literature reveals overall the great potential of GO/ polymer nanocomposites in tissue engineering strategies and indicates also a series of challenges requiring further research efforts.

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“…In addition to its advantageous combination with nanocarbon materials, nanocellulose is an appealing material for biomedical applications due to its tunable chemical fluorescence and luminescence [26,71,72] photothermal activity [56], hydrolytic stability [61], nanoporous character and high adsorption capacity [49,61]. Nanocellulose/nanocarbon composites can therefore be used in a wide range of industrial and technological applications, such as water purification [22,29,43,49,54,56,61,[73][74][75][76], the isolation and separation of various molecules [22,74,[77][78][79], energy generation, storage and conversion [21,23,44,47,64,[80][81][82][83][84][85], biocatalysis [86], food packaging [67][68][69]87], construction of fire retardants [48], heat spreaders [70] and shape memory devices [38,[88][89][90]. These comp...…”

Section: Introductionmentioning

confidence: 99%

Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

et al. 2020

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Nanocellulose/nanocarbon composites are newly emerging smart hybrid materials containing cellulose nanoparticles, such as nanofibrils and nanocrystals, and carbon nanoparticles, such as “classical” carbon allotropes (fullerenes, graphene, nanotubes and nanodiamonds), or other carbon nanostructures (carbon nanofibers, carbon quantum dots, activated carbon and carbon black). The nanocellulose component acts as a dispersing agent and homogeneously distributes the carbon nanoparticles in an aqueous environment. Nanocellulose/nanocarbon composites can be prepared with many advantageous properties, such as high mechanical strength, flexibility, stretchability, tunable thermal and electrical conductivity, tunable optical transparency, photodynamic and photothermal activity, nanoporous character and high adsorption capacity. They are therefore promising for a wide range of industrial applications, such as energy generation, storage and conversion, water purification, food packaging, construction of fire retardants and shape memory devices. They also hold great promise for biomedical applications, such as radical scavenging, photodynamic and photothermal therapy of tumors and microbial infections, drug delivery, biosensorics, isolation of various biomolecules, electrical stimulation of damaged tissues (e.g., cardiac, neural), neural and bone tissue engineering, engineering of blood vessels and advanced wound dressing, e.g., with antimicrobial and antitumor activity. However, the potential cytotoxicity and immunogenicity of the composites and their components must also be taken into account.

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Combined effect of cellulose nanocrystal and reduced graphene oxide into poly-lactic acid matrix nanocomposite as a scaffold and its anti-bacterial activity

Cited by 111 publications

References 39 publications

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Graphene Oxide/Polymer‐Based Biomaterials

Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

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