Deoxyribonucleic acid (DNA) has been a significant factor in the criminal justice system since it was first used in forensic investigations. The reference sample's DNA profile is typically compared to the DNA profile from the evidence sample from the crime scene criminal cases. Familial DNA analysis can identify a person and provide significant investigation leads even without a reference sample for comparison in a criminal investigation process. The potential source of a forensic biological sample is determined using several indirect database searching techniques. These DNA-based techniques include Mitochondrial DNA (mtDNA) analysis, investigative genetic genealogy (IGG), familial searching, and Y-STR database searching. This study examined these methods and compares them in terms of searching efficiency, database structures, searching methods, genotyping technologies, data security, data quality, and costs. It also raises several possible legal and privacy problems for scientists to consider further. The significance of familial DNA analysis, the procedures used for finding and identifying relatives using familial DNA, and its benefits in forensics are all covered in this paper. Additionally, future options for the appropriate application of this technology and social, legal, and ethical concerns related to familial DNA analysis have been considered.