Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer

Abstract

CA242 is a marker of GBC infiltration in the early stage. CA199 and cancer of the gallbladder neck are therapeutic and prognostic markers.

A retrospective analysis of patients with gallbladder cancer: surgical treatment and survival according to tumor stage

“…However, the sensitivity is only 50% (15). Furthermore, elevated CA125, CA19.9, and CA242 levels have been reported in cases with distant lymph node metastasis (16). In our series, CA19.9 was the tumor marker that was most frequently elevated in GBC patients.…”

HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer

“…The survival rate of patients with Gallbladder cancer (GBC) treated with conventional methods remains very low due to poor prognosis. Even when combining radiation therapy and concurrent chemotherapy drug gemcitabine and cisplatin, the median patient survival is limited to very low level [5, 6]. Therefore, the identification of genes for effective targeting of GBC is a priority in current research related to the treatment of this type of tumor.…”

Combination of preoperative NLR, PLR and CEA could increase the diagnostic efficacy for I-III stage CRC

“…[14][15][16][17][18] For the diagnostic value of NLR and PLR for CRC, until now, there are only four small sized case-control studies published. 23,24 This study with large samples size was conducted in eastern Chinese population to comprehensively analyze the diagnostic value of NLR and PLR in CRC and the first attempt to explore whether this new index, combination of NLR, PLR, and CEA, could improve the diagnostic validity. Moreover, Emir 19 and Karaman's 22 studies only focused on one biomarker (NLR).…”