Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial

Comhaire, Frank; Garem, Y El; Mahmoud, Ahmed; Eertmans, Frank; Schoonjans, Frank

doi:10.1111/j.1745-7262.2005.00047.x

Cited by 179 publications

(124 citation statements)

References 17 publications

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“…However, only a few of the studies in this review evaluated this outcome, and no definitive answers have yet emerged from these trials. Fifteen in vivo studies 31,36,41,47,50,51,[62][63][64][65][66][67]69,76,82 included pregnancy rate among the end points measured; in two of these studies, a higher pregnancy rate was achieved, but was not statistically significant. 47,76 In another two studies, the pregnancy rate was lower in the antioxidant-treated group than in the control group, although the comparison was against clomiphene citrate or mesterolone rather than placebo.…”

Section: Discussionmentioning

confidence: 99%

“…An interesting in vivo study of 60 patients with idiopathic asthenozoospermia who received either placebo or 200 mg day 21 of coenzyme Q10 demonstrated significant improvement in motility after 6 months of treatment; this improvement was markedly reduced after a washout period of 3 months in treated subjects. 81 Comhaire and colleagues 82 reported a study where 30 subfertile men were administered 16 mg day 21 of astaxanthin, a carotenoid that is not converted to vitamin A in humans, for 3 months. No significant improvements in concentration, motility, morphology or volume were seen in the 11 treated men compared with the 19 control patients.…”

Section: Other Compoundsmentioning

confidence: 99%

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The role of antioxidant therapy in the treatment of male infertility: an overview

Lombardo¹,

Sansone²,

Romanelli³

et al. 2011

Asian J Androl

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In recent years, many studies have focused on the effect of oxidative stress, reactive oxygen species (ROS) and antioxidants on the male eproductive system. Under physiological conditions, sperm produces small amounts of ROS, which are needed for fertilisation, acrosome reaction and capacitation. However, if an increased production of ROS is not associated with a similar increase in scavenging systems, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. Furthermore, since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies. A definitive conclusion regarding the benefit of these therapies is difficult to obtain, as most of the previous studies lacked control groups, considered different antioxidants in different combinations and doses, or did not evaluate pregnancy rates in previously infertile couples. Even if beneficial effects were reported in a few cases of male infertility, more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility.

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Section: Discussionmentioning

confidence: 99%

Section: Other Compoundsmentioning

confidence: 99%

The role of antioxidant therapy in the treatment of male infertility: an overview

Lombardo¹,

Sansone²,

Romanelli³

et al. 2011

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…The astaxanthin dose was determined based on safety studies showing that a dose up to 45 mg per day for 4 weeks is well tolerated without serious side effects 19. Long‐term intervention studies (4 mg/day for 52 weeks25; 12 mg/day26 and 16 mg/day for 12 weeks27) reported no serious adverse side effects. The 12 mg daily dose resulted in significant improvement in cognitive measurements 26.…”

Section: Methodsmentioning

confidence: 99%

Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly

Liu

Ali

Campbell

et al. 2018

J cachexia sarcopenia muscle

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BackgroundBuilding both strength and endurance has been a challenge in exercise training in the elderly, but dietary supplements hold promise as agents for improving muscle adaptation. Here, we test a formulation of natural products (AX: astaxanthin, 12 mg and tocotrienol, 10 mg and zinc, 6 mg) with both anti‐inflammatory and antioxidant properties in combination with exercise. We conducted a randomized, double‐blind, placebo‐controlled study of elderly subjects (65–82 years) on a daily oral dose with interval walking exercise on an incline treadmill.MethodsForty‐two subjects were fed AX or placebo for 4 months and trained 3 months (3×/week for 40–60 min) with increasing intervals of incline walking. Strength was measured as maximal voluntary force (MVC) in ankle dorsiflexion exercise, and tibialis anterior muscle size (cross‐sectional area, CSA) was determined from magnetic resonance imaging.ResultsGreater endurance (exercise time in incline walking, >50%) and distance in 6 min walk (>8%) accompanied training in both treatments. Increases in MVC by 14.4% (±6.2%, mean ± SEM, P < 0.02, paired t‐test), CSA by 2.7% (±1.0%, P < 0.01), and specific force by 11.6% (MVC/CSA, ±6.0%, P = 0.05) were found with AX treatment, but no change was evident in these properties with placebo treatment (MVC, 2.9% ± 5.6%; CSA, 0.6% ± 1.2%; MVC/CSA, 2.4 ± 5.7%; P > 0.6 for all).ConclusionsThe AX formulation improved muscle strength and CSA in healthy elderly in addition to the elevation in endurance and walking distance found with exercise training alone. Thus, the AX formulation in combination with a functional training programme uniquely improved muscle strength, endurance, and mobility in the elderly.

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“…The study also reported that antioxidant intake, to some extent, may attenuate the impact of age on sperm motility. Some studies that implemented an oral antioxidant therapy with different antioxidants were associated with a significant improvement in both spontaneous and assisted conception pregnancy rates [9,11,28,39].…”

Section: Total (95% Ci)mentioning

confidence: 99%

Coenzyme Q10 and male infertility: a meta-analysis

Lafuente

González-Comadran

Solà

et al. 2013

J Assist Reprod Genet

138

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Objective To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility. Materials and methods Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group. Results None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I 2 =17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I 2 =58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I 2 =0 %)Conclusion There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice.

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Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial

Abstract: Although the present study suggests a positive effect of Astaxanthin on sperm parameters and fertility, the results need to be confirmed in a larger trial before recommending Astaxanthin for the complementary treatment of infertile men.

Cited by 179 publications

References 17 publications

The role of antioxidant therapy in the treatment of male infertility: an overview

The role of antioxidant therapy in the treatment of male infertility: an overview

Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly

Coenzyme Q10 and male infertility: a meta-analysis

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