Coenzyme Q10 and male infertility: a meta-analysis

Lafuente, Rafael; González-Comadran, Mireia; Solà, Iván; López, Gemma; Brassesco, M.; Carreras, Ramón; Checa, Miguel Ángel

doi:10.1007/s10815-013-0047-5

Cited by 138 publications

(112 citation statements)

References 44 publications

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“…L-Carnitine and coenzyme Q10 are strong antioxidants that prevent LPO and sperm DNA fragmentation. Meta-analysis indicated that both elements improved the conventional sperm parameters [105,106]. And as to L-Carnitine, erectile function was also improved [105].…”

Section: Oral Antioxidant Therapymentioning

confidence: 90%

Reactive Oxygen Species and Sperm Cells

Takeshima¹,

Kuroda²,

Yumura³

2018

Reactive Oxygen Species (ROS) in Living Cells

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Many cases of male factor infertility are idiopathic, but 30-40% of cases may have excessive levels of reactive oxygen species (ROS) in their semen. The origins of endogenous ROS are leukocytes and immature spermatozoa, and external causes are various. On the contrary, seminal plasma contains various antioxidants. Low levels of ROS are essential for the fertilization process, but excessive levels of ROS lead to oxidative stress and can have harmful effects such as lipid peroxidation of a membrane, sperm deoxyribonucleic acid fragmentation, and apoptosis on the fertile capacity. In order to evaluate oxidative stress appropriately, ROS is measured by the chemiluminescence method with neat semen and quantification of 8-OH-2′-deoxyguanosine and malondialdehyde in seminal plasma. Antioxidant potential is often measured using total antioxidant capacity (TAC) assay. The oxidation-reduction potential measured by a MiOXSYS analyzer is a novel, easier, quicker, and less expensive technology to measure oxidative stress. In order to minimize oxidative stress and improve clinical outcomes, sperm-sorting methods, lifestyle modifications, shortening the ejaculatory abstinence, and treatments such as oral antioxidants, varicocelectomy, and testicular sperm extraction are taken into account. As a future prospect, proteomics, metabolomics, and genomics are still developing areas that have the potential to discover new findings and highly sensitive biomarkers.

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Section: Oral Antioxidant Therapymentioning

confidence: 90%

Reactive Oxygen Species and Sperm Cells

Takeshima¹,

Kuroda²,

Yumura³

2018

Reactive Oxygen Species (ROS) in Living Cells

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“…There are currently six meta-analyses of antioxidant treatment for male infertility available (22,(26)(27)(28)(29)(30) and all report improvements in pregnancy rate and sperm quality after therapy. From a clinical viewpoint, the possibility to reduce sperm DNA fragmentation in 56% of otherwise untreatable infertile patients is certainly an ethically and economically sound approach.…”

Section: Discussionmentioning

confidence: 99%

Effect of superoxide dismutase supplementation on sperm DNA fragmentation

Negri¹,

Benaglia²,

Monti³

et al. 2017

Arch Ital Urol Androl

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Background: antioxidants supplementation improves sperm quality, but few trials have analyzed the effects on sperm DNA fragmentation (SDF). This study compares the effectiveness of SOD-based antioxidant supplementation plus hydroxytyrosol and carnosol in reducing SDF with other antioxidants without SOD, hydroxytyrosol, and carnosol. Materials and methods: men with high SDF at baseline were selected in our clinical database. The patients taken into account had a 2-month control. SDF was measured by Sperm Chromatin Dispersion test (SCD). Untreated men were used as a control group. The remaining subjects received some oral antioxidant supplements (12 different combinations of both hydrophilic and lipophilic antioxidants), with some of them receiving nutritional support with a SOD-based antioxidant supplementation plus hydroxytyrosol and carnosol. Results: 118 men were selected for a retrospective study. Mean age 39.3 ± 5.4 years. Fifteen had no treatment, 55 were treated with a SOD-based antioxidant supplementation plus hydroxytyrosol and carnosol, and 48 took some antioxidant supplements for 2 months. Clinically, variations of at least 10% in baseline values of classic semen parameters and sperm DNA fragmentation were taken into consideration. Classic seminal parameters did not vary significantly in the three groups, with the exception of viability (p = 0.001). We assessed which of the active substances (no. 19) in different formulations were associated with variations in SDF. In the multivariable analysis of the 7 active substances that passed the univariable analysis, only the SOD molecule appeared to be linked to an improvement in SDF (< 0.0001). In detail, only one patient in the control group showed a spontaneous improvement in SDF (6%), compared to 16/48 (33%) of those taking various oral antioxidant supplements, and 31/55 (56%) of those taking a SOD-based antioxidant supplementation plus hydroxytyrosol and carnosol. Conclusions: SOD-based antioxidant supplementation plus hydroxytyrosol and carnosol seems to provide a better chance of improving sperm DNA integrity than other classical antioxidant molecules.KEY WORDS: Sperm DNA fragmentation: Male infertility; Superoxide dismutase; Hydroxytyrosol; Carnosol. with pregnancy in natural cycles (1), intrauterine inseminations (2), and in-vitro procedures (3). SDF is also associated with recurrent miscarriage (4), both during in-vivo and in-vitro procedures. It is well known that SDF may be present in men with both normal and abnormal semen analysis (5) and that infertile men have higher proportions of sperm with DNA damage compared to fertile men (6). Cohen-Bacrie et al. (2009) (7) found elevated levels of sperm DNA damage in over 60% of men attending fertility clinics, with 30% being severe. Because conventional semen analysis is a poor predictor of sperm DNA damage (8), SDF assays have been suggested in selected cases of infertility, e.g. unexplained infertility, recurrent miscarriages, and asthenoteratozoospermia. Abortive apoptosis, infection, defective sperma...

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“…A recent meta-analysis including 3 randomized controlled trials revealed that CoQ10 supplementation increases CoQ10 concentration in seminal fluid and improves sperm concentration and motility. However, only one of those studies reported spontaneous conception outcomes; that study did not demonstrate a significant difference in pregnancy rates between the treated and placebo groups 8 .…”

Section: Introductionmentioning

confidence: 94%

Coenzyme Q10 Intake From Food and Semen Parameters in a Subfertile Population

Tiseo

Gaskins

Hauser

et al. 2017

Urology

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Objective To assess the association between coenzyme Q10 (CoQ10) intake from food sources and semen quality. We assessed this association in a prospective cohort of men attending a fertility clinic. CoQ10 supplementation has been associated with improvements in semen parameters. However, impact of CoQ10 intake from food sources on semen quality has not been investigated. Methods Subfertile couples seeking fertility evaluation at the Massachusetts General Hospital Fertility Center were invited to participate in an ongoing study of environmental factors and fertility. In total, 211 male participants completed a validated food frequency questionnaire and provided 476 semen samples. Multivariable linear mixed models were used to examine the relation between CoQ10 intake from foods and semen parameters while adjusting for potential confounders and accounting for within-person correlations. Results Mean dietary CoQ10 intake was 19.2 mg/day (2.4–247.2 mg/day). No subjects were taking CoQ10 supplements. There were no associations between dietary CoQ10 intake from foods and conventional semen parameters. The adjusted mean difference (95% confidence interval) comparing men in the top and bottom quartiles of CoQ10 intake from foods were −3.1 mil/mL (95% CI −29.5, 38.8 mil/mL) for sperm concentration, −4.5% (−15.1%, 6.0%) for total motility, −1.3% for progressive motility (−8.4%, 5.7%) and 0.3% (−1.4%, 2.0%) for sperm morphology. Conclusions CoQ10 intake from foods was not related to semen parameters among subfertile men. Mean dietary intake of CoQ10 in this study was 10-fold lower than the supplemental dose used in clinical trials showing improved sperm motility. CoQ10 intake from foods alone may be insufficient to optimize semen parameters.

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Coenzyme Q10 and male infertility: a meta-analysis

Cited by 138 publications

References 44 publications

Reactive Oxygen Species and Sperm Cells

Reactive Oxygen Species and Sperm Cells

Effect of superoxide dismutase supplementation on sperm DNA fragmentation

Coenzyme Q10 Intake From Food and Semen Parameters in a Subfertile Population

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