Combined coinage metal catalysis for the synthesis of bioactive molecules

Palladium‐Catalyzed Cycloisomerization of (Z)‐1‐Iodo‐1,6‐dienes to 3‐Aza‐bicyclo[4.1.0]hept‐2‐enes

“…In 2009, Marinetti group applied cyclometalated ( N ‐heterocyclic carbene)‐Pt II complexes bearing monodentate phosphines as ancillary ligands in highly enantioselective cycloisomerizations of 1,6‐enyne . In 2015, Cramer group demonstrated a chiral cyclopentadienyl Iridium(III) complexes promoted enantioselective cycloisomerizations of terminal alkynes . Meanwhile, from 2002 to 2005, José, Max and Louis et al .…”

Bifunctionalized Allenes. Part XIII. A Convenient and Efficient Method for Regioselective Synthesis of Phosphorylated α-Hydroxyallenes with Protected and Unprotected Hydroxy Group

“…There are variety of methods for the construction of hydroxyallenes that include prototropic rearrangement of propargylic alcohols [14,15,16], metal-catalyzed nucleophilic addition of propargylic derivatives to aldehydes [17,18,19,20,21,22,23,24], Cu(I)-catalyzed reaction of propargylic chlorides with Grignard reagents [25,26,27], metal-catalyzed reaction of propargylic oxiranes with organometallic compounds [28,29,30,31,32,33,34,35] and ketones [36,37], reduction of alcohols, ethers, oxiranes etc. with aluminium reagents [38,39,40], Pd(0)-catalyzed reaction of cyclic carbonates with acetylenic compounds [41,42], S N 2’ [43,44] and A N [45,46,47] reactions of metalled alkoxy-allenes with oxiranes and ketones [5], and other routes [48,49].…”

Gold-catalyzed C–O bond forming reactions for the synthesis of six-membered O-heterocycles

“…In contrast to this, the N-Boc-protected hydroxylamine ethers were treated with Au(I) chloride to afford oxazines via a 6-endo-cyclization. This process was versatile because same-hydroxyallenes underwent Mitsunobu reaction to synthesize allenic hydroxylamine ethers precursors for the preparation of heterocyclic compounds stereoselectively [280,281].…”