Combined choriocarcinoma and adenocarcinoma of the lung occurring in a man

Chen, Fengshi; Tatsumi, Akitoshi; Numoto, Satoshi

doi:10.1002/1097-0142(20010101)91:1<123::aid-cncr16>3.0.co;2-3

Cited by 50 publications

(46 citation statements)

References 19 publications

(20 reference statements)

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“…In our case, the tumor was consisted of a choriocarcinomatous component (cytotrophoblastic and syncytiotriphoblastic cells) and poorly diffenrentiated adenocarcinoma. To our knowledge, only one case of combined choriocarcinoma and adenocarcinoma of the lung has been reported by Chen et al so far [3]. Chen et al reported that there is the possibility that choriocarcinoma and adenocarcinoma arouse simultaneously or formed a collision tumor; however, it is considered that the choriocarcinoma might occur directly in the lung through trophoblastic differentiation of some cells in the former adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Choriocarcinoma syndrome after resection of primary pulmonary choriocarcinoma: report of a case

Takahashi

Kobayashi

2016

surg case rep

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BackgroundChoriocarcinoma syndrome is known as a lethal complication from tumoral hemorrhage, which frequently occurs at the site of tumor metastasis.Case presentationA 59-year-old man with 60-pack-year smoking history was referred to our hospital because of hemoptysis. Chest computed tomography (CT) showed a 28 × 18 mm spiculated nodule with a cavity infiltrating the left upper lobe. A transbronchial lung biopsy was performed, and histopathological examinations revealed adenocarcinoma. No distant or regional metastasis was observed, and therefore, the patient underwent a left upper lobectomy with lymphadenectomy. Histological examinations showed that the tumor consisted of poorly differentiated adenocarcinoma cells and a choriocarcinomatous component; no multiple pulmonary metastases and mediastinal lymph node metastasis were observed. Immunohistochemical analysis showed a positive immunoreaction for human chorionic gonadotropin in the syncytiotrophoblastic cells of the choriocarcinoma. One month after the operation, the patient developed massive hemoptysis. CT showed diffuse alveolar infiltration in both the lungs. A bronchoscopic examination showed bleeding from the right upper bronchus. Aspiration cytology showed carcinoma. Despite blood transfusion and management in the intensive care unit, the patient died one and a half month after diagnosis.ConclusionsWe herein report a case of a man who developed choriocarcinoma syndrome 1 month after resection for combined choriocarcinoma and adenocarcinoma of the lung. Choriocarcinoma syndrome is a rare and life-threatening complication which may occur in patients with primary pulmonary choriocarcinoma. However, we need to consider the risk of this syndrome while dealing with patients who have massive hemoptysis.

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Section: Discussionmentioning

confidence: 99%

Choriocarcinoma syndrome after resection of primary pulmonary choriocarcinoma: report of a case

Takahashi

Kobayashi

2016

surg case rep

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“…However, the finding of a coexistent somatic neoplasm in other cases of endometrial YST, principally those arising in perimenopausal and postmenopausal women, suggests that a proportion of cases arise as a result of ''neometaplasia'' or ''retrodifferentiation,'' or from malignant pluripotent somatic stem cells, as has been postulated to occur in the ovary and at extragonadal sites such as the stomach (18). There are similarities between the occurrence of a YST component in association with a somatic neoplasm and the presence of a component of choriocarcinoma in adenocarcinomas of various organs, such as the lung, breast, uterus, colon, and bladder (19)(20)(21)(22)(23). Two cases of pure endometrial YST have been reported in women of perimenopausal age and we suspect that these were somatically derived with complete overgrowth of the native tumor by the YST.…”

Section: Discussionmentioning

confidence: 99%

Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma

Damato

Haldar

McCluggage

2016

International Journal of Gynecological Pathology

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Yolk sac tumors (YSTs) with a somatic glandular pattern can be difficult to recognize histologically because they reproduce developing intestinal, hepatic, or lung tissue and can express markers such as CDX2 and TTF1. We report an unusual case of a primary endometrial YST showing florid endodermal-intestinal differentiation in a 63-yr-old woman with a history of colorectal adenocarcinoma. Histologically, the tumor exhibited a glandular and papillary architecture and showed widespread immunoreactivity for CDX2 and focal staining for CK20 and CEA, mimicking metastatic colorectal carcinoma on biopsy. The presence of subnuclear cytoplasmic clearing and positive staining for germ cell markers, however, pointed toward a diagnosis of primary endometrial YST, and this was supported by the radiologic and the subsequent pathologic finding of a primary endometrial-based lesion. YSTs in this age group usually arise in association with somatic tumors and in this case a small focus of coexistent endometrioid adenocarcinoma was identified within the uterus. Despite surgery and adjuvant chemotherapy, the patient showed disease progression with liver and lung metastases 6 mo postoperatively.

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“…Table 1 lists 31 cases of lung carcinoma with trophoblastic differentiation, or the choriocarcinoma of the lung, retrieved from the English literature [3][4][5][6][7][8]. For 18 of the 31 cases, including duplicates, anti-cancer chemotherapy was employed using the regimens shown in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Primary Lung Adenocarcinoma With Trophoblastic Differentiation and Usage of Gefitinib for Postoperative Recurrence: Report of a Case With a Review of the Literature

2016

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We report a rare and very aggressive case of lung carcinoma showing trophoblastic differentiation, so-called choriocarcinoma, for which postoperative recurrence was treated using gefitinib. A 51-year-old woman with pathological stage IIA adenocarcinoma with trophoblastic differentiation underwent left lower lobectomy with lymph node dissection and postoperative adjuvant chemotherapy, remaining tumor-free for 10 months until the detection of the brain metastasis. Gefitinib was administered, as the tumor was positive for epidermal growth factor receptor mutation, and this resulted in a 12-month progression-free period. The patient died 37 months after surgery due to multiple metastases in the brain, ovary and uterus. This is the first case report using gefitinib to the lung carcinoma showing trophoblastic differentiation. A review of the literature on lung cancer with trophoblastic differentiation suggested that a chemotherapeutic regimen for primary lung cancer other than germ cell tumor might be suitable for the lung carcinoma with trophoblastic differentiation.

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Combined choriocarcinoma and adenocarcinoma of the lung occurring in a man

Cited by 50 publications

References 19 publications

Choriocarcinoma syndrome after resection of primary pulmonary choriocarcinoma: report of a case

Choriocarcinoma syndrome after resection of primary pulmonary choriocarcinoma: report of a case

Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma

Primary Lung Adenocarcinoma With Trophoblastic Differentiation and Usage of Gefitinib for Postoperative Recurrence: Report of a Case With a Review of the Literature

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