Combined cell index in assessing blood donor iron stores

Vuk, Tomislav; Bingulac-Popović, Jasna; Očić, Tihomir; Mayer, Ljiljana; Milošević, Milan; Jukić, Irena

doi:10.1111/tme.12370

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Previous studies have shown that ATO is absorbed into the bloodstream, where it binds with HGB and is rapidly distributed to tissues and organs [12,13]. Routine clinical erythrocyte analyses include seven parameters [14]: RBC count, HGB, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular HGB (MCH), mean corpuscular HGB concentration (MCHC), and RDW. The RBC count and HGB are absolute values that serve as important indicators of anemia, whereas the HCT expresses RBC as a percentage of the whole blood volume, reflecting the ratio of RBC to plasma.…”

Section: Discussionmentioning

confidence: 99%

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

Su¹,

Sun²,

Wang³

et al. 2018

Infection International

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The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Wistar rats were randomly divided into four study groups that were treated with saline (control) or arsenic trioxide at a low (0.1 mg/mL), medium (1 mg/mL), or high (10 mg/mL) dose by intratracheal instillation. Blood samples were collected for analysis at 6, 12, 24, 48, and 72 h after exposure. Compared with the control group, intratracheal instillation of arsenic trioxide affected hematopoietic differentiation in rats, leading to blood cell changes that were related to observation time and concentration.

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Section: Discussionmentioning

confidence: 99%

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

Su¹,

Sun²,

Wang³

et al. 2018

Infection International

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“…Dear Sir, Iron deficiency in blood donors is an important adverse consequence of frequent blood donations (Vuk et al, 2017). Numerous studies have been published so far with the aim of reducing this risk and improving the well-being of blood donors.…”

Section: Influence Of Cigarette Smoking On Haemoglobin Concentration mentioning

confidence: 99%

Influence of cigarette smoking on haemoglobin concentration – do we need a different approach to blood donor selection?

Očić

Jukić

2017

Transfusion Medicine

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“…3,4,17,18 Our study has shown a moderate correlation between serum ferritin and RDW, a relationship that has not been well described before, except the idea of using combined (red) cell index. 19 Measurement of the RDW comes at no additional cost when a CBC is performed.…”

Section: Discussionmentioning

confidence: 99%

Iron deficiency in whole blood donors in a resource‐poor setting: A cross‐sectional study in Uganda

Dhabangi

Ssenyonga

Siu

et al. 2023

Transfusion Medicine

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Background and Objective Blood donation is known to result in iron deficiency (ID), with a higher prevalence in females. There is little published data on the frequency of ID among blood donors in resource‐poor settings. We determined the prevalence of ID in blood donors in Uganda. Methods We conducted a descriptive cross‐sectional study at the Uganda Blood Transfusion Service, Kampala from December 2021 to February 2022. A sample of 500 whole blood donors was enrolled. The evaluation included demographic characteristics, donation history, nutritional history, complete blood count, and serum ferritin. The primary outcome was the proportion of donors with serum ferritin <15 μg/L. Results The median (IQR) serum ferritin was 25 (12–47) μg/L and 89 (52–133) μg/L among female and male donors respectively. The prevalence of iron deficiency (serum ferritin <15 μg/L) among donating individuals was 11.5% (8.7–14.9), while among low haemoglobin deferrals, 61.5% (50.9–71.1). The prevalence was high among females [33.0% (27.9–38.6)] compared with males [2.5% (1.0–5.8)], but even higher among females younger than 24 years [35.4% (29.2–42.1)]. Factors associated with ID (adjusted odds ratio, 95% Cl, and significance) were; female donors (15.81, 5.17, 48.28, p < 0.001) and a high RDW (6.89, 2.99, 15.90, p < 0.001). We found a moderate correlation between serum ferritin and RDW (r = −0.419 and −0.487 for males and females respectively). Conclusion Iron deficiency is common among blood donors in Uganda, affecting mostly young female donors. Considerations to adopt evidence‐based strategies to prevent and manage ID among blood donors–such as serum ferritin monitoring and iron supplementation are highly recommended.

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Combined cell index in assessing blood donor iron stores

Abstract: Study results confirmed the satisfactory diagnostic value of CCI in detecting depleted iron stores in blood donors.

Cited by 5 publications

References 24 publications

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

Influence of cigarette smoking on haemoglobin concentration – do we need a different approach to blood donor selection?

Iron deficiency in whole blood donors in a resource‐poor setting: A cross‐sectional study in Uganda

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