Combined bactericidal activity of silver nanoparticles and hexadecylpyridinium salicylate ionic liquid

Abstract

Recently, ionic liquids have been used as dispersing agents for silver nanoparticle (AgNP) preparation. In this paper, we have shown a simple method to prepare AgNP in aqueous media using an ionic liquid called hexadecylpyridinium salicylate (HDPSal) as dispersing agent. The dispersions were produced by the chemical reduction of silver ions in aqueous media with different concentrations of HDPSal and tetrabutylammonium borohydride as reducing agent. The UV-Visible electronic spectra showed the characteristic plasmonic resonance band around 420 nm, confirming the formation of AgNPs. The TEM images confirmed the formation of spherical particles with diameters lower than 10 nm. The charge of these particles was determined by Zeta potential and they were around ?50 mV, indicating that the HDP cations are surrounding the AgNPs, avoiding their agglomeration. Most of the dispersions remained stable for at least 1 month. Microbiological assays showed that the combination of AgNP with HDPSal results in wider range of antimicrobial effect.

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

“…621 Employment of cetylpyridinium salicylate, which itself possessed antibacterial activity, as dispersing agent for silver nanoparticles allowed one to produce nanoformulations with a broader antibacterial effect. 628 Unsurprisingly, biological activity of API-ILs turned out to depend on the ion structure. Thus, the cation nature influenced antibacterial activity of dual-active API-ILs combining an antibacterial agent (didecyldimethylammonium, benzalkonium, cetylpyridinium, or 3-hydroxy-1-octyloxymethylpyridinium) with an artificial sweetener (acesulfame or saccharinate).…”

“…812 Of note, Ag nanoparticles with enhanced antimicrobial activity were produced using [C 16 Py][Sal] as dispersing agent. 628 At the end of this section, we would like to mention a recent report on the application of ILs for skin tissue engineering.…”

“…Using rhodamin 6G-based IL-like compounds, a cooperative effect of both ions on antitumor activity was demonstrated . Employment of cetylpyridinium salicylate, which itself possessed antibacterial activity, as dispersing agent for silver nanoparticles allowed one to produce nanoformulations with a broader antibacterial effect …”

Advanced oxidation processes for the removal of [bmim][Sal] third generation ionic liquids: effect of water matrices and intermediates identification

“…10,11 Furthermore, the third generation of ionic liquids includes salts with a melting point below 100 C that contain biologically active cations and/or anions in the structure. 12,13 A special attention of the scientic community in the recent years has been paid to ionic liquids with salicylate anion, since they show possibility of a wide range of applications in the eld of pharmaceutical industry, 14 the synthesis of nanoparticles, 15 heat storage, 16 electrodeposition of transition metals 17 etc. Complexing (chelating) ability of salicylate anions was used for the synthesis of the hydrophobic ionic liquids for selective metal (metalloid) extraction from the industrial and the communal wastewaters.…”

Biosynthesis of xanthangum‐coated INPs by using Xanthomonas campestris

“…High negative value zeta potential is a key indicator of the stability of colloidal dispersions. Surface charges larger than ±30 mV can provide a sufficient repulsive force to prevent agglomeration of nanoparticles and produce stable dispersions [67–69]. All of these findings confirm the successful fabrication of colloidally stable nanoparticles.…”