Combined Antioxidant Treatment Effects on Blood Oxidative Stress after Eccentric Exercise

Goldfarb, Allan H.; McKenzie, Michael J.

doi:10.1249/01.mss.0000152887.87785.be

Cited by 122 publications

(119 citation statements)

References 28 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Close et al [39] reported greater increases in CK activity up to 24 hours and increases in oxidative stress up to 72 hours following downhill running at 65% VO 2max as compared to level running and suggested that exercise-induced muscle damage may increase oxidative stress due to the production of reactive oxygen species, which later initiate damaging mechanism. Studies with eccentric resistive exercise confirmed that an increase in oxidative stress following repeated eccentric contraction is associated with simultaneous increase in indices of muscle damage [21,22,40].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that acute eccentric exercise may produce free radicals not only by an enhanced rate of oxygen utilization but also by anaerobic metabolism and secondary inflammation due to the phagocytic activity of immune cells [14,21,22]. Activated neutrophils and macrophages infiltrate damaged muscle, which may be beneficial to muscle repair [23,24]; however, it may also trigger further inflammatory processes and additional muscle damage, in part through an enhanced formation of uncontrolled free radical reactivity in the vicinity of phagocytic activity [25][26].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis

Park

Man-Gyoon

2015

J. Exerc. Nutr, Biochem.

View full text Add to dashboard Cite

Kyung-Shin Park and Man-Gyoon Lee. Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis. JENB., Vol. 19, No. 2, pp.55-63, 2015 [Purpose] The purpose of this study was to investigate the effect of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis.[Methods] Thirteen moderately trained male subjects performed three 40 min treadmill runs at ~70% VO2max on separate days: a level run (L) followed by two downhill runs (DH1 and DH2). Blood samples were taken at rest (PRE) and immediately (POST), 2 h, 24 h, and 48 h after each run. Data were analyzed using 2-way repeated measures ANOVA with post hoc Tukey tests.[Results] Creatine kinase (CK) activity and oxidative stress level were significantly elevated at 24 h and 48 h following DH1 (P < 0.05). The level of oxidative stress at the POST measurement following DH1 and DH2 was greater than PRE. The rate of leukocyte apoptosis was significantly increased at the POST measurement following all three runs, and remained elevated for up to 48 h following DH1 (P < 0.01).[Conclusion] CK activity and oxidative stress were elevated following an acute bout of moderate intensity downhill running, resulting in a greater apoptotic response at 24 h and 48 h post-exercise in comparison with level grade running or a second downhill run. These elevations were blunted following DH2. Although the link between exercise-induced muscle damage and leukocyte apoptosis is currently unknown, the differential response to DH1 vs. L and DH2 indicates that it may be mediated by the elevation of oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis

Park

Man-Gyoon

2015

J. Exerc. Nutr, Biochem.

View full text Add to dashboard Cite

show abstract

“…We recently reported in highly trained runners a decrease in antioxidant parameters after repetition of oxidative stimuli (intense hypoxic exercises) during 6 weeks (Pialoux et al, 2006). In this context, an antioxidant supplementation during intense training could maintain physiological antioxidant values and limit ROS damages induced by physical exercise (Schroder et al, 2000;Goldfarb et al, 2005;Morillas-Ruiz et al, 2006). However, the efficiency of antioxidant on the cellular protection against ROS has not yet been fully established.…”

Section: Discussionmentioning

confidence: 99%

Effects of the ‘live high–train low’ method on prooxidant/antioxidant balance on elite athletes

Pialoux¹,

Mounier²,

Rock

et al. 2008

Eur J Clin Nutr

View full text Add to dashboard Cite

Background/Objectives: We previously demonstrated that acute exposure to hypoxia (3 h at 3000 m) increased oxidative stress markers. Thus, by using the 'living high-training low' (LHTL) method, we further hypothesized that intermittent hypoxia associated with endurance training alters the prooxidant/antioxidant balance. Subjects/Methods: Twelve elite athletes from the Athletic French Federation were subjected to 18-day endurance training. They were divided into two groups: one group (control group) trained at 1200 m and lived in hypoxia (2500-3000 m simulated altitude) and the second group trained and lived at 1200 m. The subjects performed an acute hypoxic test (10 min at 4800 m) before and immediately after the training. Plasma levels of advanced oxidation protein products (AOPP), malondialdehydes (MDA), ferric-reducing antioxidant power (FRAP), lipid-soluble antioxidants normalized for triacylglycerols, and cholesterol and retinol were measured before and after the 4800 m tests. Results: After the training, MDA and AOPP concentrations were decreased in response to the 4800 m test only for the control group. Eighteen days of LHTL induced a significant decrease of all antioxidant markers (FRAP, P ¼ 0.01; a-tocopherol, P ¼ 0.04; b-carotene, P ¼ 0.01 and lycopene, P ¼ 0.02) for the runners. This imbalance between antioxidant and prooxidant might result from insufficient intakes in vitamins A and E. Conclusions: The LHTL model characterized by the association of aerobic exercises and intermittent resting hypoxia exposures decreased the antioxidant status whereas the normoxic endurance training induced preconditioning mechanisms in response to the 4800 m test.

show abstract

“…Οι περισσότερες εργασίες ωστόσο, αναφέρουν σημαντικά υψηλότερες συγκεντρώσεις υπεροξείδωσης λιπιδίων (Childs, Jacobs, Kaminski, Halliwell, & Leeuwenburgh, 2001;Close, et al, 2006;Close, et al, 2004;Close, Ashton, Cable, et al, 2005;Maughan, et al, 1989;Nikolaidis, et al, 2007;Paschalis, et al, 2007;Paschalis, Nikolaidis, et al, 2010a) σε ένα τουλάχιστον χρονικό σημείο μετά την άσκηση. Σημαντικό στοιχείο που προέκυψε από αυτές τις εργασίες είναι ότι δεν είχε αναφερθεί καμία επίδραση της έκκεντρης άσκησης στην λιπιδική υπεροξείδωση τις πρώτες ώρες μετά το τέλος της άσκησης (Cannon, et al, 1990;Close, et al, 2004;Close, Ashton, Cable, et al, 2005c;Goldfarb, et al, 2005;Nikolaidis, et al, 2007;Paschalis, et al, 2007;Paschalis, Nikolaidis, et al, 2010a;Sacheck, et al, 2000;Sacheck, et al, 2003). Από την άλλη οι εργασίες οι οποίες ανέφεραν αλλαγές μετά την άσκηση στην λιπιδική υπεροξείδωση, υποδεικνύουν ότι οι αλλαγές συνέβηκαν χρονικά από την 2 η μέχρι και την 4 η μέρα μετά το τέλος της έκκεντρης άσκησης.…”

Section: έκκεντρη άσκηση και οξειδοαναγωγική κατάσταση του αίματοςunclassified

“…Οι εργασίες που μελέτησαν την επίδραση της λήψης αντιοξειδωτικών βιταμινών C και Ε μεμονωμένα ή συνδυαστικά για περιορισμό της μυϊκής βλάβης και του οξειδωτικού στρες μετά από έκκεντρη άσκηση έχουν να επιδείξουν αντικρουόμενα αποτελέσματα. Οι περισσότερες από αυτές τις εργασίες, όπως φαίνεται συνοπτικά στους Πίνακες 1, 2 και 3, αναφέρουν ότι η λήψη βιταμίνης C και βιταμίνης Ε, συνδυαστικά ή μεμονωμένα, μπορεί να έχει έστω κάποια θετική επίδραση σε κάποιο δείκτη μυϊκής απόδοσης και οξειδωτικού στρες σε κάποια χρονική στιγμή μετά από έκκεντρη άσκηση (Beaton, et al, 2002;Bryer & Goldfarb, 2006;Cannon, et al, 1991;Goldfarb, et al, 2005;Kaminski & Boal, 1992;Phillips, et al, 2003;Sacheck, et al, 2003;Shafat, et al, 2004) . Θα πρέπει ωστόσο να αναφερθεί ότι ενώ αυτές οι εργασίες αναφέρουν θετική επίδραση της λήψης βιταμινών σε ένα δείκτη σε κάποιο χρονικό σημείο, στην ίδια εργασία κάποιος άλλος δείκτης δεν είχε υποστεί καμιά επίδραση από τη λήψη των βιταμινών.…”

Section: Petersen Et Al 2001unclassified

Η Επίδραση Της Έκκεντρης Προπόνησης Σε Δείκτες Μυϊκής Βλάβης Και Οξειδωτικού Στρες

Θεοδώρου¹

View full text Add to dashboard Cite

Anastasios A. Theodorou : The effect of eccentric training on muscle damage and redox status indices (Under the supervision of Athanasios Jamurtas, Assistand Professor)Antioxidant supplementation is quite often among athletes in an attempt to counteract the increased production of free radicals during exercise and especially after exerciseinduced muscle damage (eccentric). Recently an increasing number of studies reported negative effects of antioxidant supplementation on the training and cellular adaptations to chronic exercise. The aim of the present study was to investigate the effects of vitamin C and E supplementation on muscle performance, blood and muscle redox status, hemolysis and blood lipid profile in both trained and untrained individuals after acute and chronic exercise. After previous investigations of our group, a specific type of exercise was applied (eccentric) in order to produce long lasting and extensive changes in all biomarkers and examine more easily any effects of antioxidant supplementation. In a double-blinded fashion, participants received either a daily oral supplementation of vitamin C and vitamin E (n=14) or placebo (n=14) for eleven weeks. Following baseline tests, volunteers performed an eccentric exercise session two times per week for four weeks. Before and after the chronic eccentric exercise volunteers were subjected to one session of acute eccentric exercise, and physiological measurements were performed as well as blood samples and muscle biopsies (from 8 participants) were collected. The present results failed to support any effect of antioxidant supplementation; eccentric exercise similarly modified muscle damage and performance, blood redox status, hemolysis and lipid profile in both supplemented and non-supplemented groups. This is despite the fact that eccentric exercise induced marked changes in muscle damage and performance as well as redox status and lipid profile for several days after exercise. The complete lack of any effect on the physiological and biochemical outcome measures employed questions the validity of using orally antioxidant supplementation as redox modulators of muscle and redox status in healthy humans. Moreover, the lack of any effect of antioxidant supplementation on training and cellural adaptation to exercise observed in this study, opposed previous studies suggesting that antioxidant may block training adaptations.

show abstract

Combined Antioxidant Treatment Effects on Blood Oxidative Stress after Eccentric Exercise

Abstract: These data suggest that eccentric resistance exercise can increase blood biomarkers of oxidative stress in non-resistance trained females, and this vitamin E, C, and selenium supplementation can attenuate the rise in PC and MDA.

Cited by 122 publications

References 28 publications

Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis

Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis

Effects of the ‘live high–train low’ method on prooxidant/antioxidant balance on elite athletes

Η Επίδραση Της Έκκεντρης Προπόνησης Σε Δείκτες Μυϊκής Βλάβης Και Οξειδωτικού Στρες

Contact Info

Product

Resources

About