Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis

Park, Kyung-Shin; Man-Gyoon, Lee

doi:10.5717/jenb.2015.19.2.55

Cited by 4 publications

(9 citation statements)

References 31 publications

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“…Byrnes et al [193] reported smaller increases in plasma CK, plasma myoglobin and DOMS up to 48 h after a second DR bout when two 30 min bouts (slope: − 10%; intensity: 170 beats min −1 of heart rate recorded on level grade) were separated by 3-, 6-and 9-weeks. Further studies corroborated these results by reporting a lower leakage and/ or a faster clearance of intracellular muscle proteins in the blood [46,63,67,85,92,121,141,143,165,181,185], lower DOMS [63,68,85,92,121,141,143,185,192,196,197] and enhanced recovery of MVC force/torque [63] after a second DR bout (Table 1 and Fig. 3b).…”

Section: Prior Exposure To Downhill Runningsupporting

confidence: 60%

“…3 a Schematic representation of the time course of alterations following downhill running (DR) and b current scientific evidence on the benefits of different adaptation strategies to DR (i.e. prior exposure to DR [46,63,67,68,85,92,121,141,143,165,181,184,185,192,193,196,197], preconditioning strategies [16,81], DR training [14,209,210,254], changes in stride pattern [32,67,68,218,219,221,220,228,255], the use of lower limb compression garments [15,236,237], and the use of specific footwear [28,149,253,256]. In a and b, orange, blue, red, purple, and green spheres correspond to isometric MVC force/torque loss, changes in running economy and mechanics, ultrastructural alterations, inflammation and oedema, and muscle soreness, respectively.…”

Section: Prior Exposure To Downhill Runningmentioning

confidence: 99%

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Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review

et al. 2020

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Downhill running (DR) is a whole-body exercise model that is used to investigate the physiological consequences of eccentric muscle actions and/or exercise-induced muscle damage (EIMD). In a sporting context, DR sections can be part of running disciplines (off-road and road running) and can accentuate EIMD, leading to a reduction in performance. The purpose of this narrative review is to: (1) better inform on the acute and delayed physiological effects of DR; (2) identify and discuss, using a comprehensive approach, the DR characteristics that affect the physiological responses to DR and their potential interactions; (3) provide the current state of evidence on preventive and in-situ strategies to better adapt to DR. Key findings of this review show that DR may have an impact on exercise performance by altering muscle structure and function due to EIMD. In the majority of studies, EIMD are assessed through isometric maximal voluntary contraction, blood creatine kinase and delayed onset muscle soreness, with DR characteristics (slope, exercise duration, and running speed) acting as the main influencing factors. In previous studies, the median (25th percentile, Q1; 75th percentile, Q3) slope, exercise duration, and running speed were − 12% (− 15%; − 10%), 40 min (30 min; 45 min) and 11.3 km h−1 (9.8 km h−1; 12.9 km h−1), respectively. Regardless of DR characteristics, people the least accustomed to DR generally experienced the most EIMD. There is growing evidence to suggest that preventive strategies that consist of prior exposure to DR are the most effective to better tolerate DR. The effectiveness of in-situ strategies such as lower limb compression garments and specific footwear remains to be confirmed. Our review finally highlights important discrepancies between studies in the assessment of EIMD, DR protocols and populations, which prevent drawing firm conclusions on factors that most influence the response to DR, and adaptive strategies to DR.

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Section: Prior Exposure To Downhill Runningsupporting

confidence: 60%

Section: Prior Exposure To Downhill Runningmentioning

confidence: 99%

Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review

et al. 2020

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“…We also measured oxidative stress (ie, d‐ROMs) and oxidative elimination ability (ie, BAP); however, these factors did not change over time and no significant difference was found between the CUR and PLA trials or between the experimental trials. In previous studies, oxidative stress markers significantly increased after whole body exercise, such as downhill running . One study reported that the product of oxidative stress was significantly suppressed by ingesting CUR .…”

Section: Discussionmentioning

confidence: 98%

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

Tanabe

Chino

Ohnishi

et al. 2019

Scandinavian Med Sci Sports

131

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We examined the effect of curcumin (CUR) ingestion before or after exercise on changes in muscle damage and inflammatory responses after exercise. We conducted two parallel experiments with different CUR ingestion timings using a double‐blind crossover. In Exp. 1, ten healthy men ingested 180 mg d−1 of CUR or placebo (PLA) 7 days before exercise. In Exp. 2, ten other healthy men ingested 180 mg d−1 of CUR or PLA 7 days after exercise. They performed 30 maximal isokinetic (120°s−1) eccentric contractions of the elbow flexors using an isokinetic dynamometer, and this was repeated with the other arm ≥4 weeks later. Maximal voluntary contraction (MVC) torque of the elbow flexors, elbow joint range of motion (ROM), muscle soreness, and serum creatine kinase (CK) activity were measured before, immediately after, and 1‐7 days after exercise. Plasma interleukin‐8 (IL‐8) was measured before, immediately after, 12 hours after, and 1‐7 days after exercise. The changes were compared over time. In Exp. 1, no significant differences were found between CUR and PLA subjects for each parameter. However, increases in IL‐8 were significantly reduced 12 hours after exercise when CUR was ingested before exercise. In Exp. 2, compared to the PLA subjects, MVC torque and ROM were higher 3‐7 days and 2‐7 days after exercise (P < 0.05), respectively, whereas muscle soreness and CK activity were lower 3‐6 days and 5‐7 days after exercise (P < 0.05), respectively, in CUR subjects. CUR ingestion before exercise could attenuate acute inflammation, and after exercise could attenuate muscle damage and facilitate faster recovery.

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“…Therefore, any downhill running or walking may cause increased stress on the popliteus muscle and tendon [ 8 ]. High intensity exercise may induce a proteolytic pathway related to muscle damage and trigger inflammatory processes in the muscle [ 9 ]. The cause of the patient's condition was difficult to ascertain, but his hobby and walking habits could have resulted in enlargement and edema of the popliteus muscle.…”

Section: Discussionmentioning

confidence: 99%

Neurovascular Compression Caused by Popliteus Muscle Enlargement Without Discrete Trauma

Cho

Kang

et al. 2016

Ann Rehabil Med

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Popliteal entrapment syndrome caused by isolated popliteus muscle enlargement is very rare, although its occurrence has been reported after discrete trauma. However, popliteal artery stenosis with combined peroneal and proximal tibial neuropathy caused by popliteus muscle enlargement without preceding trauma has not been reported. A 57-year-old man presented with a tingling sensation and pain in his left calf. He had no previous history of an injury. The symptoms were similar to those of lumbosacral radiculopathy. Calf pain became worse despite treatment, and the inability to flex his toes progressed. Computed tomography angiography and magnetic resonance imaging of the lower extremity showed popliteal artery stenosis caused by popliteus muscle enlargement and surrounding edema. An electrodiagnostic study confirmed combined peroneal and proximal tibial neuropathy at the popliteal fossa. Urgent surgical decompression was performed because of the progressive neurologic deficit and increasing neuropathic pain. The calf pain disappeared immediately after surgery, and he was discharged after the neurologic functions improved.

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Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis

Cited by 4 publications

References 31 publications

Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review

Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

Neurovascular Compression Caused by Popliteus Muscle Enlargement Without Discrete Trauma

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