Combined Antihaemophilic Globulin and Christmas Factor Deficiency in Haemophilia

Antihaemophilic Globulin and Plasma Thromboplastin Component Deficiencies Associated with a Qualitative Platelet Disturbance

“…Pla telet dysfunction has also been described in patients with plasma thromboplastin component deficiency (29). The combination of antihaemophilic globulin and plasma thromboplastin component deficiencies has been described, although it is very rare (30)(31)(32). Recently, a case with a triple clotting deficiency, similar to ours, was also described (33).…”

Hemophilia B — Mutation Rates and Incidence — A Simulation Study

“…In an editorial, Ponder (2011) comments on the costs of protein therapy for hemophilia B and the welcome success of gene therapy reported in the same issue of the journal. Verstraete andVandenbroucke (1955, p. 1533) state 'In the last year haemophilia has been separated into different typesnamely, the well-defined classical haemophilia A (antihaemophilic globulin deficiency) and Christmas disease or haemophilia B (Christmas factor deficiency, factor IX deficiency, plasma thromboplastin component deficiency)'. Koller (1954) cites studies, including his own, contributing to this differentiation and gives a rudimentary diagram locating types A and B separately on the X chromosome.…”

Different Haemostatic Defects in One Family

“…In spite of the multiplicity of the possible causes of defective haemostasis, the various members of a particular family are usually found to have the same anomaly, even when this comprises more than one factor. Few exceptions have been previously recorded: Verstraete and Vandenbroucke (1955) found one member of a known haemophilic family to have combined antihaemophilic globulin and Christmas factor deficiency, and Bell and Alton (1955) reported a family in whom both sexes showed deficiency of factor VII, while some of the males were thought to suffer from Christmas disease as well.…”