Combined analyses and extended follow‐up of two randomized controlled homocysteine‐lowering B‐vitamin trials

Ebbing, Marta; Bønaa, Kaare Harald; Arnesen, Egil; Ueland, Per Magne; Nordrehaug, Jan Erik; Rasmussen, Knut; Njølstad, Inger; Nilsen, Dennis W.T.; Refsum, Helga; Tverdal, Aage; Vollset, Stein Emil; Schirmer, Henrik; Bleie, Øyvind; Steigen, Terje K.; Midttun, Øivind; Fredriksen, Åse; Pedersen, Eva Kristine Ringdal; Nygård, Ottar

doi:10.1111/j.1365-2796.2010.02259.x

Cited by 67 publications

(43 citation statements)

References 45 publications

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“…23 Moderately increased plasma levels of Hcy and genetic factors associated with enzymatic abnormalities of folic acid and Hcy metabolism play an important role in the development of CVD. 24,25 Most studies that reported higher Hcy levels in bipolar patients were carried out during euthymia and focused on functional and cognitive deterioration. [26][27][28] To our knowledge, this is the first study to assess Hcy levels in the same patients in both states, mania and euthymia; it is also the first study to attempt to correlate Hcy with markers of CVD.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Chiarani

Tramontina

Ceresér

et al. 2013

Rev. Bras. Psiquiatr.

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Objective: To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances: during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls. Methods: The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP). Results: Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP. Conclusions: These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD.

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Section: Discussionmentioning

confidence: 99%

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Chiarani

Tramontina

Ceresér

et al. 2013

Rev. Bras. Psiquiatr.

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“…364 Beneficial effects ascribed to anti-oxidants were based on 365 epidemiological as well as in-vitro studies. However, when tested 366 in large scale RCTs, little or no effects have been found [56]; or 367 perhaps even harm as for beta-carotene with an increased lung 368 cancer risk [57] and for folic acid plus vitamin B12 an increased 369 cancer and all-cause mortality risk [58]. We should therefore take …”

Section: Introductionmentioning

confidence: 97%

Vitamin D and health: The need for more randomized controlled trials

Jorde

Grimnes

2015

The Journal of Steroid Biochemistry and Molecular Biology

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“…A recent analysis suggests that cardiovascular risk prediction by tHcy is confined to the Hcy fraction that does not respond to B-vitamins. 89 There are mechanisms that are "resistant" to Hcy-lowering action of folic acid. For example, elevated tHcy can result in production of autoantibodies directed against N-Hcy-protein adducts, 86 that tend to remain increased despite reduction in tHcy.…”

Section: Undas and Ariëns Fibrin Clot Properties And Thrombosis E91mentioning

confidence: 99%

Fibrin Clot Structure and Function

Undas

Ariëns

2011

ATVB

437

200

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Abstract-The formation of fibrin clots that are relatively resistant to lysis represents the final step in blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in relation to thrombotic disease. In addition, we discuss the implications of fibrin structure for treatment of thrombosis. Fibrin clots composed of compact, highly branched networks with thin fibers are resistant to lysis. Altered fibrin structure has consistently been reported in patients with several diseases complicated by thromboembolic events, including patients with acute or prior myocardial infarction, ischemic stroke, and venous thromboembolism. Relatives of patients with myocardial infarction or venous thromboembolism display similar fibrin abnormalities. Low-dose aspirin, statins, lowering of homocysteine, better diabetes control, smoking cessation, and suppression of inflammatory response increase clot permeability and susceptibility to lysis. Growing evidence indicates that abnormal fibrin properties represent a novel risk factor for arterial and venous thrombotic events, particularly of unknown etiology in young and middle-aged patients. (Arterioscler Thromb Vasc Biol. 2011;31:e88-e99.)

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Combined analyses and extended follow‐up of two randomized controlled homocysteine‐lowering B‐vitamin trials

Abstract: Abstract. Ebbing M.,

Cited by 67 publications

References 45 publications

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Vitamin D and health: The need for more randomized controlled trials

Fibrin Clot Structure and Function

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