Combined Action of Thioperamide Plus Scopolamine, Diphenhydramine, or Methysergide on Memory in Mice

Molinengo, L; Carlo, Giovanni Di; Ghi, Piera

doi:10.1016/s0091-3057(98)00229-9

Cited by 19 publications

(17 citation statements)

References 26 publications

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“…We found, using the passive-avoidance model, that H 3 Ϫ/Ϫ mice showed normal learning behavior but were insensitive to the amnesia-inducing effects of scopolamine. This is consistent with previous reports showing that thioperamide could at least partially prevent the effects of scopolamine (Blandina et al, 1996;Onodera et al, 1998;Molinengo et al, 1999).…”

Section: Discussionsupporting

confidence: 94%

“…For instance, Molinengo et al (1999) showed that the effects of thioperamide on memory consolidation seemed dependent on the situation, with or without painful stress. Also, Passani et al (2000) indicated that thioperamide did not improve memory in normal mice, but only in a learning deficit situation.…”

Section: Discussionmentioning

confidence: 99%

“…Open field habituation was assessed by a modification of the method of Molinengo et al (1999). In brief, animals were placed individually in an open field apparatus (50 ϫ 50 cm), and their locomotion distance was measured for 5 min using a videotracking system.…”

Section: Open Field Habituationmentioning

confidence: 99%

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Behavioral Characterization of Mice Lacking Histamine H₃ Receptors

et al. 2002

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Brain histamine H 3 receptors are predominantly presynaptic and serve an important autoregulatory function for the release of histamine and other neurotransmitters. They have been implicated in a variety of brain functions, including arousal, locomotor activity, thermoregulation, food intake, and memory. The recent cloning of the H 3 receptor in our laboratory has made it possible to create a transgenic line of mice devoid of H 3 receptors. This paper provides the first description of the H 3 receptor-deficient mouse (H 3 Ϫ/Ϫ ), including molecular and pharmacologic verification of the receptor deletion as well as phenotypic screens. The H 3 Ϫ/Ϫ mice showed a decrease in overall locomotion, wheel-running behavior, and body temperature during the dark phase but maintained normal circadian rhythmicity. H 3 Ϫ/Ϫ mice were insensitive to the wake-promoting effects of the H 3 receptor antagonist thioperamide. We also observed a slightly decreased stereotypic response to the dopamine releaser, methamphetamine, and an insensitivity to the amnesic effects of the cholinergic receptor antagonist, scopolamine. These data indicate that the H 3 receptor-deficient mouse represents a valuable model for studying histaminergic regulation of a variety of behaviors and neurotransmitter systems, including dopamine and acetylcholine.The neurotransmitter histamine, which originates from tuberomamillary nuclei in the posterior hypothalamus, projects diffusely throughout the central nervous system (CNS) and has been implicated in the regulation of many functions, including sleep/wake, food and water intake, thermoregulation, memory, and other homeostatic processes (Wada et al., 1991;Brown et al., 2001). Four subtypes (H 1 , H 2 , H 3 , and H 4 ) of histamine receptors are currently recognized (Hill et al., 1997;Hough, 2001). The H 3 subtype is predominantly located presynaptically and serves as an autoreceptor to regulate the synthesis and release of histamine (Hill et al., 1997). The H 3 subtype also has heteroreceptor functions and influences CNS dopamine, ␥-aminobutyric acid, noradrenaline, acetylcholine, and serotonin levels (Arrang et al., 1983(Arrang et al., , 1987bSchlicker et al., 1988;Clapham and Kilpatrick, 1992;Hill et al., 1997). Behavioral correlates of H 3 receptor function have primarily been studied in the context of pharmacologically blocking the receptor using the specific H 3 receptor antagonist, thioperamide. For instance, thioperamide has been used to increase the amount of wakefulness (Monti et al., 1991), to prevent scopolamine-induced amnesia (Giovannini et al., 1999), and to decrease food intake (Itoh et al., 1999;Attoub et al., 2001) in rats. The recent cloning of the H 3 receptor in our laboratory (Lovenberg et al., 1999) has made it possible to create a transgenic line of mice devoid of H 3 receptors and to explore at a molecular level the importance of this receptor in a variety of behaviors. This paper provides the first description of 1) generating the H 3 receptor knockout mice, 2) verifying the d...

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Behavioral Characterization of Mice Lacking Histamine H₃ Receptors

et al. 2002

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“…Administration of thioperamide, histamine, or histidine, decreased investigation time of a juvenile rat by an adult rat while immepip or inhibition of histamine synthesis by afluoromethylhistidine prolonged recognition time (Prast et al, 1996). However, H 3 receptor blockade might be beneficial under condition of cognitive impairments caused by cholinergic dysfunction (Miyazaki et al, 1995a(Miyazaki et al, , b, 1997Blandina et al, 1996Blandina et al, , 1998Gulat-Marnay et al, 1989a, b;Giovannini et al, 1999;Molinengo et al, 1999). In a two-arm maze using a metal box and a glass bottle as objects in the retention trial and two identical objects in the first trial, H 3 receptor blockade antagonized scopolamine-induced object recognition impairments and object recognition impairments at 90-and 120-min intertrial intervals at which male and female rats, respectively, did not exhibit object recognition anymore in this version of the test .…”

Section: Discussionmentioning

confidence: 99%

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Bongers

Leurs

Robertson

et al. 2003

Neuropsychopharmacol

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Increasing evidence supports a role for histamine as a neurotransmitter and neuromodulator in emotion and cognition. The H 3 receptor was first characterized as an autoreceptor that modulates histamine release and synthesis via negative feedback. Mice deficient in apoE (Apoe -/-) have been used to define the role of apoE in brain function. In the present study, we investigated the possible role of histamine H 3 -receptor-mediated signaling in anxiety and cognition in mice Apoe -/-and wild-type mice. H 3 antagonists increased measures of anxiety in wild-type, but not Apoe -/-, mice. In contrast, H 3 antagonists similarly impaired object recognition in wild-type and Apoe -/-mice. In Apoe -/-mice, reduced negative feedback via H 3 receptors could contribute to increased signaling of H 1 receptors. Apoe -/-mice showed higher sensitivity to the anxiety-reducing effects of the H 1 receptor antagonist mepyramine than wild-type mice. These effects were dissociated from effects of mepyramine on the HPA axis. Compared to saline controls, mepyramine reduced plasma ACTH and corticosterone levels in wild-type, but not Apoe -/-, mice. These data support a role for apoE in H 3 receptor signaling. H 3 antagonists were proposed as a treatment for cognitive disorders such as Alzheimer's disease, which is associated with increased anxiety and cognitive impairments. As H 3 antagonists increase measures of anxiety and impair object recognition in wild-type mice, the use of H 3 antagonists in cognitive disorders may be counterproductive and should be carefully evaluated.

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“…This deficit can also be reversed by pro-cholinergic drugs, such as galantamine and donepezil (65), so it is possibly due to a failure of various transmitter systems. Interestingly, the H3 receptor antagonist thioperamide has been reported to enhance consolidation in some tasks or brain regions (74,199,426,466) and also to antagonize the enhancing action of histamine in others. H3 receptors act through fostering the release both of acetylcholine and of histamine itself from axon terminals (62, 441).…”

Section: Histaminementioning

confidence: 99%

Fear Memory

Izquierdo

Furini

Myskiw

2016

Physiological Reviews

339

241

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Fear memory is the best-studied form of memory. It was thoroughly investigated in the past 60 years mostly using two classical conditioning procedures (contextual fear conditioning and fear conditioning to a tone) and one instrumental procedure (one-trial inhibitory avoidance). Fear memory is formed in the hippocampus (contextual conditioning and inhibitory avoidance), in the basolateral amygdala (inhibitory avoidance), and in the lateral amygdala (conditioning to a tone). The circuitry involves, in addition, the pre-and infralimbic ventromedial prefrontal cortex, the central amygdala subnuclei, and the dentate gyrus. Fear learning models, notably inhibitory avoidance, have also been very useful for the analysis of the biochemical mechanisms of memory consolidation as a whole. These studies have capitalized on in vitro observations on long-term potentiation and other kinds of plasticity. The effect of a very large number of drugs on fear learning has been intensively studied, often as a prelude to the investigation of effects on anxiety. The extinction of fear learning involves to an extent a reversal of the flow of information in the mentioned structures and is used in the therapy of posttraumatic stress disorder and fear memories in general.

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Combined Action of Thioperamide Plus Scopolamine, Diphenhydramine, or Methysergide on Memory in Mice

Cited by 19 publications

References 26 publications

Behavioral Characterization of Mice Lacking Histamine H₃ Receptors

Behavioral Characterization of Mice Lacking Histamine H₃ Receptors

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Fear Memory

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Combined Action of Thioperamide Plus Scopolamine, Diphenhydramine, or Methysergide on Memory in Mice

Cited by 19 publications

References 26 publications

Behavioral Characterization of Mice Lacking Histamine H3 Receptors

Behavioral Characterization of Mice Lacking Histamine H3 Receptors

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Fear Memory

Contact Info

Product

Resources

About

Behavioral Characterization of Mice Lacking Histamine H₃ Receptors

Behavioral Characterization of Mice Lacking Histamine H₃ Receptors