Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

Misra, Santosh K.; Wang, X.; Srivastava, Indrajit; Imgruet, Molly; Graff, Robert W.; Ohoka, Ayako; Kampert, Taylor L.; Gao, Haifeng; Pan, Dongli

doi:10.1039/c5cc07709e

Cited by 24 publications

(21 citation statements)

References 27 publications

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“…The researchers used ATRP of inimers in microemulsion, and were able to load a drug combination of DNA damage repair agents and also STAT-3 inhibitors (amonafide and niclosamide respectively). 114 and colleagues, to form highly branched polymer prodrug conjugates with both redox sensitive disulphide groups and acid sensitive groups carbonate groups. 116 The presence of acidic pH conditions or glutathione environments enhances the release of camptothecin, with the polymer system having IC50 values of 365.1 g/ml, to HeLa cell-line with an MTS cell viablilty assay.…”

Section: Self-condensing Vinyl Polymerisationmentioning

confidence: 99%

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook

Perrier

2019

Adv Funct Materials

126

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Barriers to therapeutic transport in biological systems can prevent accumulation of drugs at the intended site, thus limiting the therapeutic effect against various diseases. Advances in synthetic chemistry techniques have recently increased the accessibility of complex polymer architectures for drug delivery systems, including branched polymer architectures. This article first outlines drug delivery concepts, and then defines and illustrates all forms of branched polymers including highly branched polymers, hyperbranched polymers, dendrimers, and branched–linear hybrid polymers. Many new types of branched and dendritic polymers continue to be reported; however, there is often confusion about how to accurately describe these complex polymer architectures, particularly in the interdisciplinary field of nanomedicine where not all researchers have in‐depth polymer chemistry backgrounds. In this context, the present review describes and compares different branched polymer architectures and their application in therapeutic delivery in a simple and easy‐to‐understand way, with the aim of appealing to a multidisciplinary audience.

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Section: Self-condensing Vinyl Polymerisationmentioning

confidence: 99%

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook

Perrier

2019

Adv Funct Materials

126

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“…Through the ATRP of inimers in microemulsion and subsequent ATRP of functional monovinyl monomers in solution, a series of star‐hyperbranched block copolymers were prepared by Gao and coworkers . Given that, a novel combinatorial therapy targeting triple negative breast cancer was developed by using nanoparticles of star‐hyperbranched polymers that can encapsulate two enzyme inhibitors inside.…”

Section: Applications Of Lchbpsmentioning

confidence: 99%

“…Given that, a novel combinatorial therapy targeting triple negative breast cancer was developed by using nanoparticles of star‐hyperbranched polymers that can encapsulate two enzyme inhibitors inside. The combination of drugs showed at least two‐ to fourfold better inhibition of triple negative breast cancer cells than the individual drugs and 6–20 times more selective than the parent drugs …”

Section: Applications Of Lchbpsmentioning

confidence: 99%

“…Even at this early stage of the development of this class of LCHBPs we are already seeing the emergence of a number of interesting applications being developed, which are largely dependent on their unusual long‐chain topological structures and certain peculiar properties. A variety of guest molecules including metal nanoparticles, drugs, and imaging agents have been transported with LCHBPs focusing on the stabilization of catalysts, and biomedicine as well as diagnostic purposes . The special molecular constructions of LCHBPs also provide them with promising applications in electrical conductivity and chemical sensing …”

Section: Introductionmentioning

confidence: 99%

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Long‐Chain Hyperbranched Polymers: Synthesis, Properties, and Applications

Liu

Tian

2018

Macromol. Rapid Commun.

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By combining the virtues of conventional linear and hyperbranched polymers, long‐chain hyperbranched polymers (LCHBPs) have attracted great attention. Therefore, a comprehensive summary of the research progress of LCHBPs is presented, with a particular focus on their synthetic strategies, unique properties, and potential applications. The synthetic methodologies are rationalized into four main classes according to their construction process or mechanism, namely ABx (x ≥ 2), A2 + Bx (x ≥ 3), AB + ABx (x ≥ 2), and self‐condensing vinyl polymerization. Some of their rheological properties, self‐assembly behavior, and stimuli‐response features are then discussed. Finally, the emergent applications including biomedicine, electrical conductivity, chemical sensing, and catalyst carrier, are outlined. It is anticipated that this review will stimulate more inspiration for advancing the development of this novel kind of LCHBP.

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“…Since use of a delivery system constitutes a new therapy, regardless of the efficacy of a verified F I G U R E 9 Construction of unimolecular nanocontainer for delivery of a two-enzyme inhibitor. (Reprinted from Misra et al (2015). Copyright 2015 Royal Society of Chemistry) drug, separate trials would be needed.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Recent advances on synthesis and biomaterials applications of hyperbranched polymers

Cuneo

Gao

2020

WIREs Nanomed Nanobiotechnol

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Hyperbranched polymers represent an intriguing class of shape-persistent soft nanomaterials that could be easily produced in one-pot reaction to obtain highly branched arborescent structures. Although traditional synthesis of hyperbranched polymers suffers from the poorly defined structures and broad molecular weight distribution, recent progress on synthesis methods allows the production of structurally defined polymers in tunable molecular weights, composition and degree of branching. This review summarizes the recent advance on synthesis of hyperbranched polymers and their applications as biomaterials in tissue engineering scaffolds, diagnostic probe carriers and drug delivery fields.

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Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

Cited by 24 publications

References 27 publications

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Long‐Chain Hyperbranched Polymers: Synthesis, Properties, and Applications

Recent advances on synthesis and biomaterials applications of hyperbranched polymers

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