Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo

Cote, Brianna; Carlson, Lisa Janssen; Rao, Deepa; Alani, Adam W.G.

doi:10.1016/j.jconrel.2015.06.040

Cited by 98 publications

(61 citation statements)

References 31 publications

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“…designed a series of resveratrol prodrugs with improved water solubility and mitochondrial targeting ability . Otherwise, several groups exploited nanoparticles (e.g., liposomes, polymeric micelles, and proteins) or submicron particles as resveratrol delivery systems, which were able to improve water solubility and prolong blood circulation of hydrophobic drugs, thereby realizing efficient delivery of resveratrol.…”

Section: Methodsmentioning

confidence: 99%

“…[34] Biasutto et al designed a series of resveratrol prodrugs with improved water solubility and mitochondrial targeting ability. [35][36][37] Otherwise, several groups exploited nanoparticles (e.g., liposomes, [38] polymeric micelles, [39] and proteins [40] ) or submicron particles [41] as resveratrol delivery systems, which were able to improve water solubility and prolong blood circulation of hydrophobic drugs, thereby realizing efficient delivery of resveratrol.In this paper, a novel resveratrol nanogel was synthesized via thiol-ene click polymerization. Resveratrol triacrylate (ResTA) was firstly synthesized and served as the cross-linking agent.…”

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confidence: 99%

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Facile Synthesis of Resveratrol Nanogels with Enhanced Fluorescent Emission

Chen

Yang

Xiao

et al. 2018

Macromolecular Bioscience

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Herein, a kind of fluorescent resveratrol nanogels via one‐pot thiol‐ene Michael addition polymerization of resveratrol triacrylate, 1,6‐hexanedithiol, and methoxyl poly(ethylene glycol) acrylate is prepared. The resultant nanogels can be well‐dispersed in water with a hydrodynamic radius of around 68 nm, and the nanogels are stable in both water and organic solvents. Moreover, the resveratrol nanogels exhibit elevated fluorescence intensity compared to free resveratrol, and the quantum yield of resveratrol nanogels is estimated to be 5.8 times as that of free resveratrol dispersed in water. Fluorescence image results also demonstrate that the resveratrol nanogels can be used for cell imaging in MCF‐7 human breast cancer cells. Therefore, the resveratrol nanogels are expected to be used as a trackable drug delivery system.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Facile Synthesis of Resveratrol Nanogels with Enhanced Fluorescent Emission

Chen

Yang

Xiao

et al. 2018

Macromolecular Bioscience

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“…Harmful effect induced by doxorubicin includes free radicals generation and triggering of antioxidant enzymes synthesis (9). This fact reminds antioxidant therapy trials.…”

Section: Introductionmentioning

confidence: 95%

Effect of Doxorubicin and Some Boron Compounds on Erythrocyte Fragility In Rats

Oto

Arıhan

Çelikezen³

et al. 2015

Natural Science and Discovery

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Objective: Objective: Doxorubicin is a potent antineoplastic agent used in chemical treatment of cancer. However due to their cardiotoxic effects, its use is limited and currently subject for extensive research. Cardiomyopathy caused by doxorubicin still remains as a major concern for this potent drug. This study was aimed to contribute to this issue which needs novel preventive treatment for this side effect. Materials and Methods:Boron and boron containing molecules are subject of medical research due to their properties such as antioxidant nature. They are tested in various diseases and experimental setups. In this study Boric acid, Potassium tetraborate, Amonium biborat tetrahidrat was given to male rats at 10 mg/kg/day for 6 weeks. All study groups (n=8 each) received Doxorubicin and Boron containing compounds via intraperitoneal route. Following 6 weeks blood was withdrawn and erythrocyte osmotic fragility test was applied. Results:Erythrocyte fragility values of all doxorubicin containing groups increases and become significant at 0.5, 0.6, 0.7 and 0.8% NaCl concentrations (p<0.05). Among doxorubicin groups no significant difference was observed. Results of this study suggests that doxorubicin increases erythrocyte osmotic fragility and boron containing molecules are not sufficient to recover this untoward effect on erythrocytes at the applied dosage. Conclusion:Possible mechanisms of this result and testing in a dose dependent manner can be tested in future studies.

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“…[20][21][22][23] However, the application of PTX and QUE in chemotherapy is limited by poor water solubility, short half-life, high concentration of solubilizers in their clinical formulations, and large toxic side effects which lead to poor patient compliance. [24][25][26][27] Therefore, delivery systems adapted to facilitate the targeting of these drugs and improve bioavailability need to be designed.…”

Section: Introductionmentioning

confidence: 99%

Paclitaxel and quercetin nanoparticles co-loaded in microspheres to prolong retention time for pulmonary drug delivery

Liu

Chen

Yang

et al. 2017

IJN

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High drug resistance, poor water solubility, short half-life, and low local drug concentration are obstacles for successful delivery of chemotherapeutic drugs for lung cancer. A new method involving the use of nanoparticles (NPs) for pulmonary delivery is proposed. However, use of NPs is limited by the particle size range for pulmonary drug delivery considering that NPs cannot be deposited directly into the lungs. NPs polymerized into microspheres (polymeric microspheres, PMs) will result in suitable particle sizes and retain the advantages of nanodrugs after redispersion when applied in pulmonary delivery. We report the development of novel NPs in the form of PMs loaded with paclitaxel (PTX) and quercetin (QUE) double drugs based on the synthesis of oleic acid-conjugated chitosan (OA-CTS) for pulmonary delivery. This approach is aimed toward prolonging PTX retention time in the presence of QUE and bypassing P-glycoprotein drug efflux pumps. NPs loaded with PTX or QUE were prepared with 11% substitution degree using OA-CTS as the carrier by ionic cross-linking method, which NPs loaded with PTX or QUE were used in the preparation of PMs by spray-drying. The diameters of the PMs ranged from 1 to 5 μm which had uniform size range. Scanning electron microscopy showed that PMs were polymers formed by a large number of NPs and readily redispersed (after redispersion, size of NPs ranged between 250 and 350 nm) in water within 1 h. PMs displayed slow-release characteristics at pH 4.5 and 7.4. The in vivo pharmacokinetic and biodistribution studies suggested that PMs exhibit prolonged circulation time and a markedly high accumulation in the lung. The obtained results indicate that PMs can serve as a promising pulmonary delivery system for combined pharmacotherapy using hydrophobic anticancer drugs.

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Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo

Cited by 98 publications

References 31 publications

Facile Synthesis of Resveratrol Nanogels with Enhanced Fluorescent Emission

Facile Synthesis of Resveratrol Nanogels with Enhanced Fluorescent Emission

Effect of Doxorubicin and Some Boron Compounds on Erythrocyte Fragility In Rats

Paclitaxel and quercetin nanoparticles co-loaded in microspheres to prolong retention time for pulmonary drug delivery

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