Combinatorial fluorapatite-based scaffolds substituted with strontium, magnesium and silicon ions for mending bone defects

Golafshan, Nasim; Alehosseini, Morteza; Ahmadi, Tahmineh; Talebi, Ardeshir; Fathi, Mohammadhossein; Kharaziha, Mahshid; Orive, Gorka; Castilho, Miguel; Dolatshahi-Pirouz, Alireza

doi:10.1016/j.msec.2020.111611

Cited by 26 publications

(16 citation statements)

References 48 publications

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“…[ 14 ] Yet the optimized ratio of Mg/Si for efficient regeneration of vascularized bone is still unclear. [ 15 ] Therefore, the targeted delivery and controlled release of ions should be confirmed before conducting the biological studies. Due to the flexibility in preparation and application, biodegradable microspheres are selected by researchers as microscaffolds for in vivo implantation.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Therapeutic Ion‐Based Microspheres with Precise Ratio‐Controlled Delivery as Microscaffolds for In Situ Vascularized Bone Regeneration

Wan

Yuan

et al. 2022

Adv Funct Materials

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Therapeutic ions, such as Si and Mg, play vital roles in regulating metabolism and promoting tissue repair, hence providing an efficient strategy in tissue engineering. The regenerative outcome is strongly dependent on the targeted delivery and controlled release of therapeutic ions. Nevertheless, it remains challenging to deliver multiple ions at controlled manners and ratios. Herein, hierarchical therapeutic ion‐based microspheres are fabricated. The coordinated release of Mg and Si ions at pre‐set ratios is achieved, based on which, Mg favors osteogenesis by inducing highly efficient cell recruitment and angiogenesis, and Si promotes massive collagen secretion and biomineralization to accelerate the bone maturation process. These therapeutic ion‐based microspheres (namely PNM2) can steadily release Mg and Si ions at an optimized ratio of 2:1, which shows the most significant synergistic effect on angiogenesis and osteogenesis. Furthermore, in a rat calvarial defects model, the volume and maturity of the vascularized neo‐bone tissue regenerated with PNM2 microspheres are comparable with or even surpassing those defects regenerated with growth factors and/or cell‐laden scaffolds. Overall, this platform provides a controllable strategy for the coordinated delivery of Mg/Si ions, opening a new avenue for developing therapeutic ion‐based microscaffold for tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Hierarchical Therapeutic Ion‐Based Microspheres with Precise Ratio‐Controlled Delivery as Microscaffolds for In Situ Vascularized Bone Regeneration

Wan

Yuan

et al. 2022

Adv Funct Materials

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“…Magnesium affects every stage of skeletal metabolism, and a deficit can induce bone fragility, delay bone growth, reduce bone mass density, etc. ,,, The role of magnesium on bone metabolism is that it stimulates cellular behavior, promotes angiogenesis, participates in calcification, regulates immune microenvironment, and changes pH.…”

Section: Effects Of Magnesium Ions On Bone Tissue Engineeringmentioning

confidence: 99%

Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

Chen

Zhang

Wang

et al. 2022

ACS Biomater. Sci. Eng.

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Large-sized bone defects are a great challenge in clinics and considerably impair the quality of patients’ daily life. Tissue engineering strategies using cells, scaffolds, and bioactive molecules to regulate the microenvironment in bone regeneration is a promising approach. Zinc, magnesium, and iron ions are natural elements in bone tissue and participate in many physiological processes of bone metabolism and therefore have great potential for bone tissue engineering and regeneration. In this review, we performed a systematic analysis on the effects of zinc, magnesium, and iron ions in bone tissue engineering. We focus on the role of these ions in properties of scaffolds (mechanical strength, degradation, osteogenesis, antibacterial properties, etc.). We hope that our summary of the current research achievements and our notifications of potential strategies to improve the effects of zinc, magnesium, and iron ions in scaffolds for bone repair and regeneration will find new inspiration and breakthroughs to inspire future research.

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“…Besides macro elements, such as calcium (Ca) and phosphorus (P), bone also contains trace elements, such as zinc (Zn), magnesium (Mg), strontium (Sr), and silicon (Si), which are essential for growth and development [65]. Therefore, the osseointegration of an implant can be promoted by incorporating osteogenic elements into its surface.…”

Section: Incorporating Trace Elementsmentioning

confidence: 99%

Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft tissue: A literature review

et al. 2022

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Combinatorial fluorapatite-based scaffolds substituted with strontium, magnesium and silicon ions for mending bone defects

Cited by 26 publications

References 48 publications

Hierarchical Therapeutic Ion‐Based Microspheres with Precise Ratio‐Controlled Delivery as Microscaffolds for In Situ Vascularized Bone Regeneration

Hierarchical Therapeutic Ion‐Based Microspheres with Precise Ratio‐Controlled Delivery as Microscaffolds for In Situ Vascularized Bone Regeneration

Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft tissue: A literature review

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