Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft tissue: A literature review

Chen, Tianjie; Jinno, Yohei; Atsuta, Ikiru; Tsuchiya, Akira; Stocchero, Michele; Bressan, Eriberto; Ayukawa, Yasunori

doi:10.2186/jpr.jpr_d_22_00138

Cited by 8 publications

(5 citation statements)

References 109 publications

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“…To address these key issues, appropriate surface modification strategies and corresponding technologies can be used to improve the bioactivity of PEEK surfaces while maintaining the mechanical superiority of PEEK itself . Currently, effective surface modification strategies include enhancing surface hydrophilicity, optimizing surface micromorphology and coarsening, coating bioactive materials, and innovative surface cleaning methods, among which the hydrophilic surface facilitates early cell adhesion and diffusion, and benefits the deposition of blood clots and fibrin, thereby accelerating the integration of the implant with the surrounding tissue. , The ultraviolet (UV) photofunctionalization can stimulate free groups and chemical bonds on the material surface with different wavelengths (UV–A: 315–400 nm, UV–B: 280–315 nm, and UV–C: 100–280 nm), intensities, and irradiation times to increase the free energy, and is considered a safe method to improve the hydrophilicity of the implant. , Funato et al reported in a clinical study that UV photofunctionalized implants were more stable, and the healing time was significantly shorter than the conventional implants …”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Nano Strontium Titanate Coating and Ultraviolet C Photofunctionalization on Osteogenic Performance and Soft Tissue Sealing of poly(ether–ether–ketone)

Chen,

Jinno,

Atsuta

et al. 2024

ACS Biomater. Sci. Eng.

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This study aimed to evaluate the bioactivity of poly(ether ether ketone) (PEEK) after surface modification by persistent photoconductive strontium titanate (SrTiO3) magnetron sputtering and ultraviolet (UV) C irradiation. According to the different modifications, the PEEK specimens were randomly divided into five groups (n = 38/group): PEEK, Sr100-PEEK, Sr200-PEEK, UV/PEEK, and UV/Sr200-PEEK. Then, the specimens of Sr100-PEEK and Sr200-PEEK groups were, respectively, coated with 100 and 200 nm thickness photocatalyst SrTiO3 on the PEEK surface by magnetron sputtering. Subsequently, UV–C light photofunctionalized the specimens of PEEK and Sr200-PEEK groups to form UV/PEEK and UV/Sr200-PEEK groups. The specimens were characterized by a step meter, scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive X-ray spectroscopy (EDX), and a water contact angle meter. The release test of the Sr ion was performed by inductively coupled plasma mass spectrometry (ICP–MS). In vitro study, osteogenic activity (MC3T3-E1 osteoblast-like cells) and epithelial and connective tissue attachment (gingival epithelial cells GE1 and fibroblasts NIH3T3) were analyzed in five groups. Surface morphology of the specimens was changed after coating, and the Sr content on the Sr-PEEK surface was increased with increasing coating thickness. In addition, the contact angle was increased significantly after magnetron sputtering. After UV–C photofunctionalization, the content of surface elements changed and the contact angle was decreased. The release of Sr ion was sustained, and the final cumulative release amount did not exceed the safety limit. In vitro experiments showed that SrTiO3 improved the cell activity of MC3T3-E1 and UV–C irradiation further enhanced the osteogenic performance of PEEK. Besides, UV–C irradiation also significantly promoted the cell viability, development, and expression of adhesion proteins of GE1 and NIH3T3 on PEEK. The present investigation demonstrated that nano SrTiO3 coating with UV–C photofunctionalization synergistically enhanced the osteogenic properties and soft tissue sealing function of PEEK in vitro.

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Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Nano Strontium Titanate Coating and Ultraviolet C Photofunctionalization on Osteogenic Performance and Soft Tissue Sealing of poly(ether–ether–ketone)

Chen,

Jinno,

Atsuta

et al. 2024

ACS Biomater. Sci. Eng.

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“…This property facilitates the prevention of stress-shielding effects in orthopedic applications [ 7 , 9 ]. Nevertheless, the untreated surface of PEEK exhibits a high level of hydrophobicity, leading to pronounced bioinertness and inadequate bone conduction, thereby restricting its clinical utility [ 10 , 11 ]. To enhance PEEK's bioactivity, surface modification and composite preparation serve as primary strategies [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing bioactivity and biocompatibility of polyetheretherketone (PEEK) for dental and maxillofacial implants: A novel sequential soaking process

Meng,

Nie,

Zhang

et al. 2024

Heliyon

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“…Moreover, the easy reproducibility of PEEK using digital fabrication techniques further enhances its appeal in the field of dentistry [ 14 , 15 ]. The convergence of these factors has increasingly highlighted PEEK’s role and made it a favored material in dental applications [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Dental Cement Bond Strength with Autofocus-Laser-Cutter-Generated Grooves on Polyetheretherketone Surfaces

Peng,

Ma,

Lee

et al. 2023

Polymers

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Polyetheretherketone (PEEK) is widely used in dentistry owing to its exceptional properties, including its natural appearance; however, existing surface treatment methods for bonding PEEK have limitations. Autofocus laser cutters, known for their precise engraving and cutting capabilities, offer potential for surface treatment of PEEK; thus, the objective of this study was to investigate the creation of laser groove structures on PEEK to enhance its bonding capability with dental resin cement. A dental computer-aided design and manufacturing system was used to fabricate PEEK samples, and three groove patterns (circle, line, and grid) were generated on PEEK surfaces, with air-abrasion used as the control group. The surface characteristics, cell viability, and bond strength were evaluated, and the data were statistically analyzed using one-way analysis of variance and post hoc Tukey’s tests (α = 0.05). Laser-treated PEEK exhibited a uniform texture with a groove depth of approximately 39.4 µm, hydrophobic properties with a contact angle exceeding 90°, a surface roughness of 7.3–12.4 µm, consistent topography, and comparable cell viability compared with untreated PEEK. Despite a decrease in bond strength after thermal cycling, no significant intergroup differences were observed, except for the line-shaped laser pattern. These findings indicate that the autofocus laser cutter effectively enhances the surface characteristics of PEEK by creating a uniform texture and grooves, showing promise in improving bonding properties, even considering the impact of thermal cycling effects.

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Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft tissue: A literature review

Abstract: At present, titanium (Ti) and Ti alloys are the most common dental implant materials, but the excessively high elastic modulus of Ti (102-110 GPa) does not match that of the human bone (14 GPa)

Cited by 8 publications

References 109 publications

Synergistic Effect of Nano Strontium Titanate Coating and Ultraviolet C Photofunctionalization on Osteogenic Performance and Soft Tissue Sealing of poly(ether–ether–ketone)

Synergistic Effect of Nano Strontium Titanate Coating and Ultraviolet C Photofunctionalization on Osteogenic Performance and Soft Tissue Sealing of poly(ether–ether–ketone)

Enhancing bioactivity and biocompatibility of polyetheretherketone (PEEK) for dental and maxillofacial implants: A novel sequential soaking process

Enhancing Dental Cement Bond Strength with Autofocus-Laser-Cutter-Generated Grooves on Polyetheretherketone Surfaces

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