Combinatorial effects of coral addition and plasma treatment on the properties of chitosan/polyethylene oxide nanofibers intended for bone tissue engineering

Chemical characterization of plasma-activated polymeric surfaces via XPS analyses: A review

“…Among the different surface modification approaches, non-thermal plasma surface activation has increasingly earned, in the last few decades, a high-flying position in several application fields [1][2][3][4][5]. On the one hand, the acquired supremacy of plasma treatments over other surface modification techniques is due to their versatility, simplicity, time efficiency, non-invasive character restricted to a modification depth of a few nanometers and solvent-free aspect [2,6,7].…”

“…Among the different surface modification approaches, non-thermal plasma surface activation has increasingly earned, in the last few decades, a high-flying position in several application fields [1][2][3][4][5]. On the one hand, the acquired supremacy of plasma treatments over other surface modification techniques is due to their versatility, simplicity, time efficiency, non-invasive character restricted to a modification depth of a few nanometers and solvent-free aspect [2,6,7]. On the other hand, numerous studies have redundantly demonstrated the plasma aptitude to successfully enhance or optimize, amongst others, the surface wettability, bio-and cyto-compatibility, printability, barrier properties, optical absorbance, bonding characteristics and adhesiveness of polymers [4,5,[8][9][10][11][12].…”

Biomimetic Cell–Substrate of Chitosan-Cross-linked Polyaniline Patterning on TiO2 Nanotubes Enables hBM-MSCs to Differentiate the Osteoblast Cell Type

“…Indeed, the hybrid of chitosan-based substrates with hBM-MSCs causes the hBM-MSCs to be differentiated into osteoblast and upregulate osteogenesis associated gene expression (runt-related transcription factor 2 (RUNX 2) and ALP), but the porous microenvironment of chitosan alone has low mechanical strength, making it unsuited for use in load-bearing scaffolds designed for applications in bone tissue engineering . A study by Hashemi et al suggested that the coating of chitosan on TiO 2 nanotubes via physical addition (spin coating) exhibited a biointerface to stimulate MSC proliferation and differentiation into the bone cell, as confirmed by the expression of collagen type-I and ALP. , Nevertheless, biochemical bonding has significant advantages over physical bonding, leading to chitosan-doped stable scaffolds due to the hydroxyl (-OH) and amine (-NH 2 ) chemical species on chitosan. There is a limitation in that a strong coating in the substrate exists in chitosan that hinders the successful implementation of chitosan-based scaffolds or cell interfaces in host-implant integration.…”

“…20 A study by Hashemi et al suggested that the coating of chitosan on TiO 2 nanotubes via physical addition (spin coating) exhibited a biointerface to stimulate MSC proliferation and differentiation into the bone cell, as confirmed by the expression of collagen type-I and ALP. 21,22 Nevertheless, biochemical bonding has significant advantages over physical bonding, leading to chitosan-doped stable scaffolds due to the hydroxyl (-OH) and amine (-NH 2 ) chemical species on chitosan. There is a limitation in that a strong coating in the substrate exists in chitosan that hinders the successful implementation of chitosan-based scaffolds or cell interfaces in host-implant integration.…”

Fabrication of Photoactive Electrospun Cellulose Acetate Nanofibers for Antibacterial Applications

“…Plasma technologies do not involve the use of chemical reagents, which are particularly undesirable in the alteration of materials that may have biomedical applications [24][25][26]. Plasma treatment of nanofibers can be applied to improve biocompatibility (e.g., cell-material interaction), regenerate bone or different types of tissues, immobilize proteins or enzymes onto nanofiber surface, promote bioactivity and change mechanical parameters of nanofibers [27][28][29][30][31]. Another important advantage of plasma treatment is the ability to change the surface properties of the polymer, namely the chemical structure, morphology, hydrophilicity, and surface charge, by changing some plasma treatment parameters [32].…”