Combinatorial effect of nano whitlockite/nano bioglass with FGF-18 in an injectable hydrogel for craniofacial bone regeneration

Abstract

Comparing the bone regeneration potential of nano whitlockite or nano bioglass in combination with FGF-18, loaded in an injectable, shear-thinning chitin/PLGA hydrogel for craniofacial bone regeneration.

Three‐dimensional‐poly(lactic acid) scaffolds coated with gelatin/magnesium‐doped nano‐hydroxyapatite for bone tissue engineering

“…[ 21,22 ] Whitlockite, a bioceramic containing Mg, indicated its potential in bone formation. [ 23 ] In an another study, the incorporation of chitosan nanoparticles (loaded with sinapic acid) into PCL fibers exhibited increased mineral deposition, suggesting the osteogenic effect of sinapic acid in bone tissue regeneration. [ 43 ]…”

“…The substitution of Mg into the crystal lattice of nHAp can greatly help in enhancing osteogenesis . [ 21‐23 ] Thus, the goal of this work was to make three‐dimensional‐PLA scaffolds covered with Gel/Mg‐nHAp. The designed scaffolds were attributed to various characterizations for the examination of their physicochemical, mechanical properties, cyto‐compatibility, and biodegradability as well as their ability to promote osteogenesis in vitro.…”

Silicon Nitride, a Bioceramic for Bone Tissue Engineering: A Reinforced Cryogel System With Antibiofilm and Osteogenic Effects

“…Along with this, the increasing number of bone fractures and orthopedic-related injuries due to an exponential growth of the elderly population has prompted researchers to explore bone tissue engineering to address these issues ( Bose et al, 2012 ; Gong et al, 2015 ; Longoni et al, 2018 ). Many therapeutic strategies have been suggested to promote bone regeneration, including scaffolds ( Lin et al, 2019 ; Zhang et al, 2019 ; Zhou et al, 2019 ), stem cells ( Annamalai et al, 2019 ; Kim et al, 2019 ; Kim et al, 2020 ), and osteogenic factors ( Naskar et al, 2017 ; Lee et al, 2020 ; Amirthalingam et al, 2021 ; Lee et al, 2021b ). More recently, biomaterial scaffolds that can promote bone tissue repair on their own, without the need for delivering cells, have emerged as a potentially powerful paradigm for bone tissue engineering, due to their promising advantages of reduced cost and fewer translational barriers than other regenerative medicine strategies, such as cell-based therapy ( Christman, 2019 ; Montoya et al, 2021 ).…”

A brief review of mRNA therapeutics and delivery for bone tissue engineering

“…Combining the ceramic particles in the scaffold would improve the mechanical property and help in osteogenic differentiation. 109,110 Balmayor et al developed transcriptactivated matrices (TAM) made of brin, micro-macro biphasic calcium phosphate and cmRNA of BMP-2. 91 The study showed that TAM was able to increase the osteocalcin and collagen gene expression with high mineral deposition.…”