Combinatorial development and assessment of a Zr-based metallic glass for prospective biomedical applications

Khan, Muhammad Mudasser; Deen, Kashif Mairaj; Haider, Waseem

doi:10.1016/j.jnoncrysol.2019.119544

Cited by 38 publications

(19 citation statements)

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“…Mostly monolayers or multilayers of oxides, nitrides, and carbides thin films of different elements such as Zr, Ti, Cu, Ni, Au, and Ag are used in order to enhance the surface mechanical properties [ 10 ]. However, in order to further improve the corrosion resistance and biocompatibility of the implants, the implant alloys are often coated with various multi-element thin films such as Zr-based thin films (Zr-Cu, Zr-Cu-Ag, ZrCN, Zr/ZrCN multilayer) [ 11 , 12 , 13 ] and Ti-based thin films (TiN, Ti-Cu, Ti-Zr-Si) [ 14 , 15 ]. The Young’s modulus and hardness of Zr-based thin films were reported in the range of 95–121.7 GPa and 5–7 GPa, respectively [ 12 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, in order to further improve the corrosion resistance and biocompatibility of the implants, the implant alloys are often coated with various multi-element thin films such as Zr-based thin films (Zr-Cu, Zr-Cu-Ag, ZrCN, Zr/ZrCN multilayer) [ 11 , 12 , 13 ] and Ti-based thin films (TiN, Ti-Cu, Ti-Zr-Si) [ 14 , 15 ]. The Young’s modulus and hardness of Zr-based thin films were reported in the range of 95–121.7 GPa and 5–7 GPa, respectively [ 12 , 16 ]. Ti-based thin films showed high hardness in the range of 5–12.5 GPa and elastic modulus of 90–200 GPa [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of the Silver Content on Mechanical Properties of Ti-Cu-Ag Thin Films

et al. 2021

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In this work, the ternary titanium, copper, and silver (Ti-Cu-Ag) system is investigated as a potential candidate for the production of mechanically robust biomedical thin films. The coatings are produced by physical vapor deposition—magnetron sputtering (MS-PVD). The composite thin films are deposited on a silicon (100) substrate. The ratio between Ti and Cu was approximately kept one, with the variation of the Ag content between 10 and 35 at.%, while the power on the targets is changed during each deposition to get the desired Ag content. Thin film characterization is performed by X-ray diffraction (XRD), nanoindentation (modulus and hardness), to quantitatively evaluate the scratch adhesion, and atomic force microscopy to determine the surface topography. The residual stresses are measured by focused ion beam and digital image correlation method (FIB-DIC). The produced Ti-Cu-Ag thin films appear to be smooth, uniformly thick, and exhibit amorphous structure for the Ag contents lower than 25 at.%, with a transition to partially crystalline structure for higher Ag concentrations. The Ti-Cu control film shows higher values of 124.5 GPa and 7.85 GPa for modulus and hardness, respectively. There is a clear trend of continuous decrease in the modulus and hardness with the increase of Ag content, as lowest value of 105.5 GPa and 6 GPa for 35 at.% Ag containing thin films. In particular, a transition from the compressive (−36.5 MPa) to tensile residual stresses between 229 MPa and 288 MPa are observed with an increasing Ag content. The obtained results suggest that the Ag concentration should not exceed 25 at.%, in order to avoid an excessive reduction of the modulus and hardness with maintaining (at the same time) the potential for an increase of the antibacterial properties. In summary, Ti-Cu-Ag thin films shows characteristic mechanical properties that can be used to improve the properties of biomedical implants such as Ti-alloys and stainless steel.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of the Silver Content on Mechanical Properties of Ti-Cu-Ag Thin Films

et al. 2021

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“…As per the potential‐pH diagram of the Zr, Zr‐based MG should have an enhanced corrosion resistance for a wide range of pH. The reason behind it can be attributed to the higher range of potential of Zr to form a strong and protective oxide layer, which impedes the chemical attacks . In addition, the capability of the passive layer formation by Ti is also widely known .…”

Section: Resultsmentioning

confidence: 99%

“…The reason behind it can be attributed to the higher range of potential of Zr to form a strong and protective oxide layer, which impedes the chemical attacks . In addition, the capability of the passive layer formation by Ti is also widely known . Thus, the presence of such outstanding oxide former (i.e., Zr and Ti) should provide excellent resistance toward localized corrosion.…”

Section: Resultsmentioning

confidence: 99%

Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants

et al. 2019

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The prospect of Zr‐based metallic glasses (MGs) in achieving a combination of properties, such as excellent electrochemical properties and extended biocompatibility, has been studied in this work. The combinatorial method (magnetron co‐sputtering) has been adopted to fabricate two novel quaternary MG systems (Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11) with optimized compositions. The structural analysis has been performed by the grazing incidence x‐ray diffraction and high‐resolution transmission electron microscopy to affirm the disordered structure of the MG systems. The electrochemical analysis demonstrates lower corrosion‐ (0.10 and 0.04 μA cm−2), and passive (2.93 and 1.88 μA cm−2) current densities of the MGs. In addition, the MGs are found to have higher charge transfer resistance (4.70 and 7.86 MΩ cm2) compared to the 316L stainless steel (SS) (0.15 MΩ cm2) and cp‐Ti (0.53 MΩ cm2). The electrochemical features are indicative towards higher corrosion‐resistance capabilities of Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs to prevent adverse biological reactions. Additionally, the cell proliferation analysis manifests higher cell proliferation on the Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs for the MC3T3‐E1 preosteoblast cells. Besides, the MTS assay analysis strengthens the prediction of cytocompatibility of the MGs. The integration of such unique properties makes these MG systems ideal candidates for biomedical implants.

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“…The advantages of MGs for biomedical application include corrosion resistance, [ 57 ] antibacterial properties, [ 58 ] biocompatibility, and biodegradability. [ 59 ] However, their conductivity is inferior to crystalline metals, [ 60 ] and hence have seldom been used as biosensors. It is worth acknowledging that MGs are 3D printable, [ 61 ] and that they can be thermoplastically deformed at the nanolevel.…”

Section: Materials Selection For Ec Biosensor Electrode Transducersmentioning

confidence: 99%

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

Elbadawi

Ong

Pollard

et al. 2020

Adv Funct Materials

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With the impending Industrial Revolution 4.0, the information produced by sensors will be central in many applications. This includes the healthcare sector, where affordable healthcare and precision medicine are highly sought after. Electrochemical sensors have the potential to produce affordable, high sensitivity and specificity, intuitive, and rapid point‐of‐care diagnostics. Underpinning these achievements is the choice of material and the fabrication thereof. In this review, the different types of materials used in electrochemical biosensors are reported, with a focus on synthetic conductive materials. The review demonstrates that there is an abundance of materials to select from, and compositing different types of materials further widens their applicability in biosensors. In addition, the fabrication of such materials using the state‐of‐the‐art of fabrication technology, additive manufacturing (AM), is also detailed. The need for compositing is evident in AM, as the feedstock for certain AM technologies is inherently nonconductive. Both material choice and fabrication technologies limitations are also discussed to highlight opportunities for growth. The review highlights how recent technological advancements have the potential to drive the healthcare industry toward achieving its primary goals.

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Combinatorial development and assessment of a Zr-based metallic glass for prospective biomedical applications

Cited by 38 publications

References 98 publications

Influence of the Silver Content on Mechanical Properties of Ti-Cu-Ag Thin Films

Influence of the Silver Content on Mechanical Properties of Ti-Cu-Ag Thin Films

Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

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