Combinations of Growth Factors Enhance the Potency of Islets In Vitro

Lim, Jong Yeon; Min, Bon Hong; Kim, Byoung Geun; Shin, Juyeon; Park, Chang Sook; Yoon, Tai Wook; Han, Sung Sik

doi:10.1097/mpa.0b013e318197a62e

Cited by 4 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is suggested that MSCs may exert their effects via a combination of numbers of bioactive and immunoregulatory factors. Importantly, these growth factors have been shown to promote islet survival and enhance beta cell function in several published studies [16–18]. A recent study demonstrated that co‐infusion of MSCs with BM enhanced stable mixed chimerism, which was essential for the induction of islet graft survival [19].…”

Section: Discussionmentioning

confidence: 99%

Immune modulation of co-transplantation mesenchymal stem cells with islet on T and dendritic cells

Wang

Deng

et al. 2010

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryAllogeneic pancreatic islet transplantation theoretically represents a cure for type 1 diabetes. However, current immune suppressive therapies are often associated with undesired side effects. Given this problem, and the shortage of human islet donors, the majority of type 1 diabetes patients cannot currently be offered an islet transplant. However, it has been found that mesenchymal stem cells (MSCs) could exert unique immunosuppressive effects both in vitro and in vivo. Herein we transplanted allogeneic 200 islets alone or in combination with MSCs (3 ¥ 10 6 cells) under the kidney capsules of diabetic C57LB/6 mouse. We found that the ratios of T helper type 1 (Th1) to Th2 and Tc1 to Tc2 were reduced, and the numbers of naive and memory T cells were down-regulated in peripheral blood after transplantation. In addition, the maturation, endocytosis and interleukin-12 secretion of dendritic cell (DCs)-derived bone marrow cells (BMCs) from receptor mice were suppressed. Rejection reaction was alleviated by MSCs which exerted suppressive effects through T lymphocyte subsets and DCs.

show abstract

Section: Discussionmentioning

confidence: 99%