Immunomodulatory properties of bone marrow mesenchymal stem cells

Mohanty, Aparna; Polisetti, Naresh; Vemuganti, Geeta K.

doi:10.1007/s12038-020-00068-9

Cited by 22 publications

(16 citation statements)

References 139 publications

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“…For example, anti-inflammatory and anti-apoptotic effects of MSCs ameliorate lung function through inducing the restoration of epithelial and endothelial cells and also enhancing the clearance of alveolar edema fluid in several models of ARDS. MSCs are able to secrete the anti-inflammatory cytokines (IL-10 and TGF-β) and resulting in a decreased neutrophil recruitment into the injured organs and decrease in the level of pro-inflammatory cytokines (TNF-α, IL-8, IL-6) (Mohanty et al 2020 ). Such function (secreting the anti-inflammatory agent) is part of paracrine activities of MSCs which enables them to manage the function of The cells around them including immune cells (macrophages and T cells) and non-immune cells (alveolar epithelial cells) (Harrell et al 2019 ).…”

Section: Msc-based Therapy Potentials and Challenges For Covid-19mentioning

confidence: 99%

Stem cells or their exosomes: which is preferred in COVID-19 treatment?

et al. 2022

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It only took 8 months for the pneumonia caused by a previously unknown coronavirus to turn into a global pandemic of unprecedentedly far-reaching implications. Failure of the already discovered treatment measures opened up a new opportunity to evaluate the potentials of mesenchymal stem cells and their extracellular vesicles (EVs), exosomes in particular. Eventually, the initial success experienced after the use of MSCs in treating the new pneumonia by Lnge and his team backed up the idea of MSC-based therapies and pushed them closer to becoming a reality. However, MSC-related concerns regarding safety such as abnormal differentiation, spontaneous malignant and the formation of ectopic tissues have triggered the replacement of MSCs by their secreted exosomes. The issue has been further strengthened by the fact that the exosomes leave similar treatment impacts when compared to their parental cells. In recent years, much attention has been paid to the use of MSC-derived exosomes in the treatment of a variety of diseases. With a primary focus on COVID-19 and its current treatment methods, the present review looks into the potentials of MSCs and MSC-derived exosomes in battling the ongoing pandemic. Finally, the research will draw an analogy between exosomes and their parental cells, when it comes to the progresses and challenges in using exosomes as a large-scale treatment method.

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Section: Msc-based Therapy Potentials and Challenges For Covid-19mentioning

confidence: 99%

Stem cells or their exosomes: which is preferred in COVID-19 treatment?

et al. 2022

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“…Moreover, the evidence demonstrated that both undifferentiated and differentiated BMSCs have a suppressive impression on mitogen-stimulated and alloantigen lymphocyte proliferation followed by a concomitant reduction in the production of pro-inflammatory cytokines such as TNF-α and IFN-γ [ 208 , 209 ]. Therefore, the clinical applications of human BMSCs are ranging from transplantation, immune-related disorders including autoimmune disorders and cell replacement [ 210 ].…”

Section: Immunomodulatory Properties Of Mscs: Ascs and Bmscsmentioning

confidence: 99%

Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)

et al. 2022

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The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells with their immunomodulatory properties can create a specific immune microenvironment to reduce inflammation, scarring, and support skin regeneration. This review presents an overview of current wound care techniques including skin tissue engineering and biomaterials as a novel and promising approach. We highlight the plasticity and different roles of immune cells, in particular macrophages during various stages of skin wound healing. These aspects are pivotal to promote the regeneration of nonhealing wounds such as ulcers in diabetic patients. We believe that a better understanding of the intrinsic immunomodulatory features of stem cells in implantable skin substitutes will lead to new translational opportunities. This, in turn, will improve skin tissue engineering and regenerative medicine applications.

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“…Any cause of liver inflammation is characterized by inflammatory cell infiltration. The immunoregulatory properties of BMSCs are facilitated by their interactions with immune cells like T cells, B cells, dendritic cells, macrophages, and natural killer (NK) cells in a context and microenvironment-dependent manner [ 14 ]. The pro-fibrotic factors secreted by these cells play an important role in the activation and proliferation of HSCs [ 15 ].…”

Section: Mechanism Of Bmscs In Liver Cirrhosismentioning

confidence: 99%

Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

Wang

Zhang

Wang

2021

Evidence-Based Complementary and Alternative Medicine

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Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.

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Immunomodulatory properties of bone marrow mesenchymal stem cells

Cited by 22 publications

References 139 publications

Stem cells or their exosomes: which is preferred in COVID-19 treatment?

Stem cells or their exosomes: which is preferred in COVID-19 treatment?

Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)

Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

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