Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension

Singh, Yogendra; Samuel, Vijaya Paul; Dahiya, Sunita; Gupta, Gaurav; Gillhotra, Ritu; Mishra, Anurag; Singh, Mahaveer; Sreeharsha, Nagaraja; Gubbiyappa, Shiva Kumar; Tambuwala, Murtaza M.; Chellappan, Dinesh Kumar; Dua, Kamal

doi:10.1002/bab.1799

Cited by 22 publications

(12 citation statements)

References 97 publications

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“…Interestingly, among patients with PCOS, homocysteine levels may predict pregnancy outcome, being higher in PCOS patients with recurrent pregnancy loss compared with fertile PCOS controls ( 173 ). Hyperhomocysteinemia predicts the risk of developing atherosclerosis in patients with MetS ( 174 ) and it is a risk factor for ischemic heart disease and stroke ( 175 ). A meta-analysis has shown that folic acid lowers the risk of stroke by 10% and of overall CVD by 4% in patients with hyperomocysteinemia ( 176 ).…”

Section: Introductionmentioning

confidence: 99%

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

et al. 2020

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Polycystic ovary syndrome (PCOS) is a very common endocrine and metabolic disorder with the involvement of both genetic and environmental factors. Although much has been clarified on its pathogenesis, diagnosis, clinical manifestations, and therapy, there are still areas of uncertainty. To address fundamental concepts, novel aspects and hypotheses, and future perspectives, including the possible additional benefits of treatment with nutraceuticals, an expert consensus panel formed by endocrinologists and gynecologists was established. After an independent review of the literature, the panel convened electronically on February 3, 2020, and six resolutions were created, debated, and agreed upon discussion, and finally approved in their final form in a consensus livestream meeting held on April 15. The summary of the resolutions are: (1) PCOS is a well-established medical condition that negatively affects reproduction, general health, sexual health, and quality of life; (2) the symptoms and signs of PCOS appear early in life especially in female newborns from PCOS carriers; (3) women with PCOS have significantly increased risk of pregnancy-related complications including gestational diabetes mellitus; (4) a male PCOS equivalent exists, and it may impact on metabolic health and probably on reproduction; (5) the evidence supports that medical therapy for PCOS is effective, rational, and evidence-based; (6) the evidence supports a major research initiative to explore possible benefits of nutraceutical therapy for PCOS. The proposed resolutions may be regarded as points of agreement based on the current scientific evidence available.

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Section: Introductionmentioning

confidence: 99%

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

et al. 2020

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“…In this study (Figure 1), a total of 170 (85%) patients presented with the etiology of a road traffic accident which is higher than 64% (highest in sample size) as found by Septa et.al, 7 54% as found by Cheema et al, 8 and 29.6% (highest in sample size) as found by Kunz et al 9 Since most of the patients with orbital involvement were associated with road traffic accidents, statistical analysis was done to compare the frequencies which came out to be nonsignificant. Diagnosis of these trauma patients was confirmed for orbital involvement on the basis of clinical features and diagnostic aids as was similarly performed by Jin et al 10 CT is a gold standard to assess the bony orbit status 11,12 . The Water's view is most helpful in evaluating patients with fractures of the inferior orbit and orbital rims 13,14 …”

Section: Discussionmentioning

confidence: 93%

Involvement of orbit in maxillofacial fractures: “Evaluation of its spectrum, characteristics, and treatment in 200 patients”—Prospective study

Lin

Hong

Zhang

et al. 2020

J of Cosmetic Dermatology

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Background To evaluate the orbital involvement epidemiology in facial fractures, the clinical distribution and effects of orbital involvement in these patients, the frequency and nature of treatment procedures performed for these involvements, and the immediate‐ and intermediate‐term effects of these treatment procedures. Methods Two hundred patients with hard tissue maxillofacial injuries were included in this study. Clinical examination was performed in‐depth. Images were taken to determine and confirm clinical observations and to finalize treatment modality. Orbital involvement in patients was noted as present or absent. The clinical effects and features in postoperative imaging studies were noted until 3 months after trauma in each patient. Results Out of 200 patients, about one‐third patients (58;29%) had orbital involvement and out of which 49 were males. Regarding clinical‐radiological signs in orbit involved fractures, the incidences were variable, that is, periorbital ecchymosis (77.6%), periorbital edema (74.1%), subconjunctival hemorrhage (67.2%), palpable step/crepitus in orbital rim (62.1%), infraorbital nerve paresthesia (46.6%), restricted globe movement (5.2%), orbital rim discontinuity/step (72.4%), maxillary sinuses (51.7%), orbital wall/floor/roof rupture (55.2%), and infraorbital foramen involvement (36.2%). Palpable step/crepitus in orbital rim was recovered remarkably earlier in patients of open reduction internal fixation (ORIF) group, and features of restricted globe movements, orbital rim discontinuity/step, orbital wall/floor/roof rupture, and infraorbital foramen involvement in patients were recovered immediately after open reduction and internal fixation treatment. Conclusion Early repair of the maxillofacial injuries with orbital involvement has better functional and esthetic outcome.

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“…Throughout the result, organic solvent modifications are mostly avoided when glycocalyx is detected throughout fast frozen tissues. [ 26–28 ]…”

Section: Main Methods For Studying/visualizing Glycocalyxmentioning

confidence: 99%

A review on the physiological and pathophysiological role of endothelial glycocalyx

Liu

Xuan

et al. 2020

J Biochem & Molecular Tox

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The glycocalyx is a gel‐like layer covering the luminal surface of vascular endothelial cells. It comprises of membrane‐attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma proteins. The glycocalyx maintains homeostasis of the vasculature, which includes controlling vascular permeability and microvascular tone, preventing microvascular thrombosis, and regulating leukocyte adhesion. In the past decades, the number of studies on endothelial glycocalyx has steadily grown. Glycocalyx emerged as an essential part of blood vessels involved in multiple physiological functions. Damage to glycocalyx is associated with many types of diseases. The structure and physiology and pathophysiology of the glycocalyx, as well as the clinical effects of glycocalyx degradation, are addressed throughout this study. We strive in particular to define therapeutic approaches for the survival or reparation of the glycocalyx.

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Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension

Cited by 22 publications

References 97 publications

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Involvement of orbit in maxillofacial fractures: “Evaluation of its spectrum, characteristics, and treatment in 200 patients”—Prospective study

A review on the physiological and pathophysiological role of endothelial glycocalyx

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