Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study

Dréno, Brigitte; Kaufmann, Roland; Talarico, Sérgio; Lozada, Vicente Torres; Rodríguez‐Castellanos, Marco Antonio; Gómez‐Flores, Minerva; Maubeuge, J. De; Berg, Mats; Foley, Peter; Sysa-Jędrzejowska, Anna; Kerrouche, Nabil; Paliargues, F.; Bettoli, Vincenzo

doi:10.1111/j.1365-2133.2011.10374.x

Cited by 25 publications

(39 citation statements)

References 15 publications

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“…Further improvements observed to week 12 can be sustained to week 52 [16–18]. In cases of more severe disease, there is clinical benefit in combining adapalene–BPO with lymecycline or doxycycline for 12 weeks [19, 20]. Longer term adapalene–BPO treatment for a further 6 months prevents relapse and continues to reduce acne lesions over the same timeframe [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Acne Subject Preference for Pump Over Tube for Dispensing Fixed-Dose Combination Adapalene 0.1%–Benzoyl Peroxide 2.5% Gel

Rueda

2014

Dermatol Ther (Heidelb)

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IntroductionAcne is a chronic inflammatory disease. Key to a patient’s success on fixed-dose adapalene–benzoyl peroxide (BPO) gel is ensuring adherence. Use of a pump system to deliver a pre-measured amount of gel with each pressure enables application of a more consistent dose vs. the tube, which should improve adherence. In the present study, we evaluate patient preference for two different containers for dispensing adapalene–BPO gel.MethodsIn this 15-day, open-label study, 300 subjects were asked to treat their acne using fixed-dose adapalene 0.1%–BPO 2.5% gel dispensed in either a tube or a pump once-daily for up to 7 days. At week 1, subjects switched to the alternative packaging design for the same timeframe. At the end of the treatment period, subjects were asked to complete a subject preference survey.ResultsAmong subjects completing the survey (n = 291), 79.0% (n = 230) preferred the pump for dispensing adapalene–BPO gel and 21.0% (n = 61) preferred the tube (p < 0.001). The top three characteristics of the pump were that it was easy to use (89.0%; n = 259/291), clean (73.2%; n = 213/291) and convenient (69.4%; n = 202/291). When asked to rate their experience with using the pump, 91.8% (n = 267/291; p < 0.001) of subjects reported being satisfied on a self-assessment scale. The majority of subjects stated they would tell their doctor about their preference for the pump next time adapalene–BPO gel was prescribed (76.6%; n = 223/291; p < 0.001) and would prefer the pump if both containers cost the same amount (80.1%; n = 233/291; p < 0.001).ConclusionPatients prefer using a pump instead of a tube to dispense adapalene–BPO gel. This delivery mechanism helps to ensure consistent application and thus may improve patient adherence to the prescribed acne treatment regimen.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-014-0054-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Acne Subject Preference for Pump Over Tube for Dispensing Fixed-Dose Combination Adapalene 0.1%–Benzoyl Peroxide 2.5% Gel

Rueda

2014

Dermatol Ther (Heidelb)

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“…After the comprehensive evaluation of the remaining 13 potentially relevant references, seven studies were excluded with the raw data duplicated18-24. Finally, six studies were included in the present meta-analysis5-7,14-16. The main characteristics of the six studies are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, several such trials compared the clinical outcomes of a combination treatment using doxycycline or lymecycline and A-BPO compared with doxycycline or lymecycline and vehicle in the treatment of severe acne vulgaris15,16. However, neither trial was sufficiently large enough to confirm the outcomes within subgroups.…”

Section: Introductionmentioning

confidence: 99%

Effects of Adapalene-Benzoyl Peroxide Combination Gel in Treatment or Maintenance Therapy of Moderate or Severe Acne Vulgaris: A Meta-Analysis

Zhou

Jiang

2014

Ann Dermatol

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BackgroundAn antibiotic-free, fixed-dose combination gel with adapalene (A) 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for treatment of acne vulgaris.ObjectiveTo compare the clinical outcomes of A-BPO combination gel with vehicle gel for treatment or maintenance therapy of patients with acne vulgaris.MethodsAn electronic search of the database PubMed (1966 to September 2012), Embase (1984 to September 2012), and Cochrane Controlled Trials Register (CENTRAL; 3rd Quarter, 2012) was undertaken to identify relevant studies. Main clinical outcomes were success rate, treatment-related adverse events (AEs), AEs leading to discontinuation, satisfaction with the effectiveness, and overall satisfaction.ResultsSix studies were finally included in this meta-analysis. The A-BPO group yielded better clinical outcomes regarding the success rate (p<0.00001), satisfaction with the effectiveness of treatment (p=0.005), and overall satisfaction (p=0.005) compared to the vehicle group. The incidence of treatment-related AEs in the A-BPO group was comparable with that of vehicle group (p=0.09), while the A-BPO group was associated with a slightly increase in the incidence of AEs leading to discontinuation when compared with the vehicle group (p=0.02).ConclusionA-BPO combination gel yields better clinical outcomes including success rate, satisfaction with the effectiveness, and overall satisfaction compared to vehicle gel, despite an increased incidence of AEs leading to discontinuation. The A-BPO combination agent most likely contributes to the treatment of moderate acne vulgaris rather than severe acne vulgaris, but it may be useful in maintenance therapy of patients with severe acne vulgaris.

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“…[14] Further, adapalene 0.1%/BPO 2.5% gel does not significantly differ from clindamycin 1%/BPO 5% gel in terms of efficacy. [15] It is generally well tolerated in the long term, while in the short term, higher irritation potential was observed as compared to clindamycin 1.2%/BPO 2.5% gel in a split face study. [16] Individual's skin type has not shown any significant correlation with the susceptibility to irritation from treatment with the adapalene-BPO gel, according to a sponsored meta-analysis.…”

Section: Synergistic Topical Combinationsmentioning

confidence: 99%

“…A multicentre, randomized, double-blind controlled study demonstrated the clinical benefit of combining oral lymecycline 300 mg with adapalene 0·1%-BPO 2·5% fixed-dose gel as compared to the oral antibiotic alone in moderate to severe acne vulgaris. [15] HORMONAL THERAPY Hormonal therapy is regarded as an excellent choice for women with acne who need oral contraception. Only few head to head comparative trials have been done comparing combined oral contraceptives (COC's) with other acne treatments.…”

Section: Synergistic Topical Combinationsmentioning

confidence: 99%

What′s new in the management of acne?

Arshdeep¹,

De²

2013

Indian J Dermatol Venereol Leprol

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Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study

Abstract: These results demonstrate the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris.

Cited by 25 publications

References 15 publications

Acne Subject Preference for Pump Over Tube for Dispensing Fixed-Dose Combination Adapalene 0.1%–Benzoyl Peroxide 2.5% Gel

Acne Subject Preference for Pump Over Tube for Dispensing Fixed-Dose Combination Adapalene 0.1%–Benzoyl Peroxide 2.5% Gel

Effects of Adapalene-Benzoyl Peroxide Combination Gel in Treatment or Maintenance Therapy of Moderate or Severe Acne Vulgaris: A Meta-Analysis

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