Combination of polydopamine and carbon nanomaterials coating enhances the piezoelectric responses and cytocompatibility of biodegradable PLLA nanofiber scaffolds for tissue engineering applications

Ramasamy, Madeshwaran Sekkarapatti; Bhaskar, Rakesh; Narayanan, Kannan Badri; Purohit, Shiv Dutt; Park, Sang‐Shin; Manikkavel, Amutheesan; Kim, Byungki; Han, Sung Soo

doi:10.1016/j.mtcomm.2022.104659

Cited by 13 publications

(13 citation statements)

References 75 publications

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“…Since it has been amply demonstrated that electrospun PLA scaffolds produced with a procedure similar to ours are highly biocompatible [ 41 , 55 , 56 , 57 ], the viability of the developed devices has been compared with that of PLA scaffolds.…”

Section: Resultsmentioning

confidence: 99%

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

Pitarresi

Barberi

Palumbo

et al. 2022

IJMS

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The development of biomedical systems with antimicrobial and antibiofilm properties is a difficult medical task for preventing bacterial adhesion and growth on implanted devices. In this work, a fibrillar scaffold was produced by electrospinning a polymeric organic dispersion of polylactic acid (PLA) and poly(α,β-(N-(3,4-dihydroxyphenethyl)-L-aspartamide-co-α,β-N-(2-hydroxyethyl)-L-aspartamide) (PDAEA). The pendant catechol groups of PDAEA were used to reduce silver ions in situ and produce silver nanoparticles onto the surface of the electrospun fibers through a simple and reproducible procedure. The morphological and physicochemical characterization of the obtained scaffolds were studied and compared with virgin PLA electrospun sample. Antibiofilm properties against Pseudomonas aeruginosa, used as a biofilm-forming pathogen model, were also studied on planar and tubular scaffolds. These last were fabricated as a proof of concept to demonstrate the possibility to obtain antimicrobial devices with different shape and dimension potentially useful for different biomedical applications. The results suggest a promising approach for the development of antimicrobial and antibiofilm scaffolds.

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Section: Resultsmentioning

confidence: 99%

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

Pitarresi

Barberi

Palumbo

et al. 2022

IJMS

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“…Ramasamy et al [244] reported a new method to fabricate poly(l-lactic acid) nanofibers (PLF) with good cytocompatibility, enhanced surface properties, and improved piezoelectricity using electrospinning with carbon nanomaterial (CM) and polydopamine (PD) coating strategies. The results of this study demonstrated that the fabricated scaffolds of PLF with tunable surface and piezoelectric properties could offer energetic extracellular microenvironments to speed up the tissue regeneration and healing process.…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…The live (green) and dead (red) fibroblasts can be seen on the live/dead staining assay. [244] Copyright 2022, Elsevier. b-e) Photographs of PLLA thin films obtained by using AFM b) unpolarized area before the adsorption of protein, c) unpolarized area after the adsorption of protein, d) positively polarized area after the adsorption of protein e) negatively polarized area after the adsorption of protein.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications

Mohsin

Bathaei

Istif

et al. 2023

Adv Healthcare Materials

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Recent materials, microfabrication, and biotechnology improvements have introduced numerous exciting bioelectronic devices based on piezoelectric materials. There is an intriguing evolution from conventional unrecyclable materials to biodegradable, green, and biocompatible functional materials. As a fundamental electromechanical coupling material in numerous applications, novel piezoelectric materials with a feature of degradability and desired electrical and mechanical properties are being developed for future wearable and implantable bioelectronics. These bioelectronics can be easily integrated with biological systems for applications, including sensing physiological signals, diagnosing medical problems, opening the blood‐brain barrier, and stimulating healing or tissue growth. Therefore, the generation of piezoelectricity from natural and synthetic bioresorbable polymers has drawn great attention in the research field. Herein, the significant and recent advancements in biodegradable piezoelectric materials, including natural and synthetic polymers, their principles, advanced applications, and challenges for medical uses, are reviewed thoroughly. The degradation methods of these piezoelectric materials through in vitro and in vivo studies are also investigated. These improvements in biodegradable piezoelectric materials and microsystems could enable new applications in the biomedical field. In the end, potential research opportunities regarding the practical applications are pointed out that might be significant for new materials research.

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“…When dopamine (DA) polymerizes on the surface of PLLA, its piezoelectric performance is reduced . However, polydopamine (PDA) can assist carbon nanomaterials to modify PLLA to gain extra properties, such as electrical conductivity, which can further promote the adhesion and proliferation of fibroblasts . Recently, biofunctional piezoelectric conductive materials have been reported to promote the regeneration of sciatic nerves with defects .…”

Section: Introductionmentioning

confidence: 99%

“…19 However, polydopamine (PDA) can assist carbon nanomaterials to modify PLLA to gain extra properties, such as electrical conductivity, which can further promote the adhesion and proliferation of fibroblasts. 20 Recently, biofunctional piezoelectric conductive materials have been reported to promote the regeneration of sciatic nerves with defects. 21 In particular, the aligned nanofibrous topography facilitates directional cell growth and promotes peripheral nerve regeneration.…”

Section: ■ Introductionmentioning

confidence: 99%

Aligned Electroactive Electrospun Fibrous Scaffolds for Peripheral Nerve Regeneration

Xiong,

Wei,

et al. 2023

ACS Appl. Mater. Interfaces

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Combination of polydopamine and carbon nanomaterials coating enhances the piezoelectric responses and cytocompatibility of biodegradable PLLA nanofiber scaffolds for tissue engineering applications

Cited by 13 publications

References 75 publications

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications

Aligned Electroactive Electrospun Fibrous Scaffolds for Peripheral Nerve Regeneration

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