PLoS ONE volume 9, issue 12, Pe114483 2014 DOI: 10.1371/journal.pone.0114483
Daniel G. Weber, Swaantje Casjens, Georg Johnen, Oleksandr Bryk, Irina Raiko, Beate Pesch, Jens Kollmeier, Torsten T. Bauer, Thomas Brüning
Abstract:

BackgroundFor the detection of malignant mesothelioma no single biomarker with reasonable sensitivity and specificity has been described so far. Mesothelin, the most prominent blood-based biomarker, is characterized by high specificity but low sensitivity. It might be reasonable to combine biomarkers of different molecular classes in order to improve the overall performance. The aim of this study was to assess the performance of the combination of mesothelin and miR-103a-3p as blood-based biomarker for mes…

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