Malignant mesothelioma as an oxidative stress-induced cancer: An update

Chew, Shan Hwu; Toyokuni, Shinya

doi:10.1016/j.freeradbiomed.2015.05.002

Cited by 73 publications

(64 citation statements)

References 162 publications

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“…Early in the neoplastic process, neutrophils trigger genomic instability, produce a favorable environment for tumor growth, and promote angiogenesis [42]. Neutrophils accumulated after asbestos generate substantial amounts of DNA damaging free-radicals [43]. The neutrophil influx in the peritoneal cavity of CNT-treated animals therefore contributes to explain the carcinogenicity of CNT and has been proposed as an early biomarker for predicting the carcinogenic activity of CNT [3, 4].…”

Section: Discussionmentioning

confidence: 99%

Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells

et al. 2015

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BackgroundThe asbestos-like toxicity of some engineered carbon nanotubes (CNT), notably their capacity to induce mesothelioma, is a serious cause of concern for public health. Here we show that carcinogenic CNT induce an early and sustained immunosuppressive response characterized by the accumulation of monocytic Myeloid Derived Suppressor Cells (M-MDSC) that counteract effective immune surveillance of tumor cells.MethodsWistar rats and C57BL/6 mice were intraperitoneally injected with carcinogenic multi-walled Mitsui-7 CNT (CNT-7) or crocidolite asbestos. Peritoneal mesothelioma development and immune cell accumulation were assessed until 12 months. Leukocyte sub-populations were identified by recording expression of CD11b/c and His48 by flow cytometry. The immunosuppressive activity on T lymphocytes of purified peritoneal leukocytes was assessed in a co-culture assay with activated spleen cells.ResultsWe demonstrate that long and short mesotheliomagenic CNT-7 injected in the peritoneal cavity of rats induced, like asbestos, an early and selective accumulation of monocytic cells (CD11b/cint and His48hi) which possess the ability to suppress polyclonal activation of T lymphocytes and correspond to M-MDSC. Peritoneal M-MDSC persisted during the development of peritoneal mesothelioma in CNT-7-treated rats but were only transiently recruited after non-carcinogenic CNT (CNT-M, CNT-T) injection. Peritoneal M-MDSC did not accumulate in mice which are resistant to mesothelioma development.ConclusionsOur data provide new insights into the initial pathogenic events induced by CNT, adding a new component to the adverse outcome pathway leading to mesothelioma development. The specificity of the M-MDSC response after carcinogenic CNT exposure highlights the interest of this response for detecting the ability of new nanomaterials to cause cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/s12989-016-0158-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells

et al. 2015

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“…These data provide a foundation for pursuing biological mechanism of NTP activity against cancer cells and also its role as a potential therapeutic strategy against MM. Considering studies with the iron chelator, DFO, which showed the role of iron in potentiating NTP activity, it is notable that MM is associated with increased local iron levels mediated by asbestos fiber uptake by mesothelial cells [2,3,50]. Hence, these increased local levels of iron could potentially amplify the cytotoxic activity of NTP against MM.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant mesothelioma (MM) is a rare, but aggressive neoplasm that is mostly induced by asbestos exposure [1,2]. Although the International Agency for Research on Cancer (IARC) designated all asbestos types as Group 1 carcinogens in 1987, its importance as a major health concern has yet to be fully acknowledged in some countries [3e5].…”

Section: Introductionmentioning

confidence: 99%

Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells

Shi

Wang

Ito

et al. 2016

Archives of Biochemistry and Biophysics

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“…Specifically, ROS can promote many aspects of tumor development and progression either directly by activating proinflammatory transcriptional factors such as NF- κ B and AP-1 or indirectly by inducing DNA damage and oncogene activation [12]. Meanwhile, some latest studies have cast new light on the complicated interplay network between inflammation, oxidative stress, cancer, and microRNAs (miRNAs) [13, 14]. The latter, which are a series of small noncoding RNAs (containing about 22 nucleotides), could modulate gene expression through canonical base pairing between the seed sequences of themselves and 3′ untranslated region (3′ UTR) of target mRNAs.…”

Section: Introductionmentioning

confidence: 99%

Identification of MicroRNAs Involved in Growth Arrest and Apoptosis in Hydrogen Peroxide-Treated Human Hepatocellular Carcinoma Cell Line HepG2

Luo

Wen

Gao

et al. 2016

Oxidative Medicine and Cellular Longevity

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Although both oxidative stress and microRNAs (miRNAs) play vital roles in physiological and pathological processes, little is known about the interactions between them. In this study, we first described the regulation of H2O2 in cell viability, proliferation, cycle, and apoptosis of human hepatocellular carcinoma cell line HepG2. Then, miRNAs expression was profiled after H2O2 treatment. The results showed that high concentration of H2O2 (600 μM) could decrease cell viability, inhibit cell proliferation, induce cell cycle arrest, and finally promote cell apoptosis. Conversely, no significant effects could be found under treatment with low concentration (30 μM). miRNAs array analysis identified 131 differentially expressed miRNAs (125 were upregulated and 6 were downregulated) and predicted 13504 putative target genes of the deregulated miRNAs. Gene ontology (GO) analysis revealed that the putative target genes were associated with H2O2-induced cell growth arrest and apoptosis. The subsequent bioinformatics analysis indicated that H2O2-response pathways, including MAPK signaling pathway, apoptosis, and pathways in cancer and cell cycle, were significantly affected. Overall, these results provided comprehensive information on the biological function of H2O2 treatment in HepG2 cells. The identification of miRNAs and their putative targets may offer new diagnostic and therapeutic strategies for liver cancer.

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Malignant mesothelioma as an oxidative stress-induced cancer: An update

Cited by 73 publications

References 162 publications

Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells

Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells

Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells

Identification of MicroRNAs Involved in Growth Arrest and Apoptosis in Hydrogen Peroxide-Treated Human Hepatocellular Carcinoma Cell Line HepG2

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