Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats

Fucoxanthin and lipid metabolism: A minireview

“…For instance, the anti-obese effects of FX in mice were increased through its combination with mediumchain triacylglycerols, so that the visceral fat weight gain was markedly lower and metabolic M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 7 thermogenesis in WAT was markedly higher in diabetic/obese KK-A y mice fed a mixture of FX (0.1%) and medium-chain triacylglycerols (0.9%) than in mice fed with FX (0.1%) only [38]. The application of FX with conjugated linoleic acid to the high-fat (15% fat) diet of rats resulted in reduced serum levels of triacylglycerol, glucose, and leptin, and these effects were more pronounced than the effects of FX alone [39]. The application of FX with fish oil also improved the FX effects associated with obesity.…”

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

“…Among the candidates, fucoxanthin has attracted extensive interest due to its excellent biological activities including anticancer, anti-inflammation, antioxidant and anti-angiogenic activity (Fung, Hamid, & Lu, 2013;Heo et al, 2010a;Kim et al, 2013;Sugawara, Matsubara, Akagi, Mori, & Hirata, 2006). Especially, several evidences have demonstrated that fucoxanthin shows improvement of metabolic disease such as diabetes, obesity and hepatic lipid metabolism (Hosokawa et al, 2010;Hu et al, 2012;Maeda et al, 2005;Woo et al, 2010). However, protective effect of fucoxanthin against high glucose induced oxidative stress has been examined on only mouse models (Iwasaki et al, 2012).…”

Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity

“…Several in vivo studies have demonstrated that fucoxanthin has a preventive effect on the accumulation of adipose tissue, improving insulin sensitivity, downregulating the secretion of diverse cytokines related to obesity and up- or downregulating genes related to lipid metabolism or energy expenditure. Recent studies showed that supplementation of diet with fucoxanthin downregulates the expression of pro-inflammatory cytokines such as IL-6 and PAI-1 [10] and upregulates the expression of the anti-inflammatory cytokine adiponectin [11]. Fucoxanthin has also beneficial effects on lipid and glucose plasma levels [12] thus reducing hyperinsulinemia [13].…”