Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

“…Two to four-fold reductions in MIC of the antibiotics was noted. Piperacillin+cinnamon and piperacillin +lavender FIC indices were 0.5 and 0.38, respectively [107]. The effect of combination of cinnamon and other herbal drugs was also observed on E. coli, Yersinia enterocolitica, P. aeruoginosa and Salmonella choleraesuis, S. aureus, Listeria monocytogenes, Bacillus cereus and Enterococcus faecalis.…”

Prevalence of Carbapenem Resistant Klebsiella and Proteus Clinical Isolates: A Real Threat to the Egyptian Health Care System

“…Of course, the variation in the efficacy of the tried concentrations of menthol between different studies could be simply attributed to strain variation. Yap et al, (2013) had previously emphasized on the potential of peppermint oil being as antibiotic resistance modifying agent. Also, Schelz et al, (2006) reported that the benefit of menthol-antibiotic (s) combinations could be correlated to the antiplasmid activity of menthol.…”

Essential Oils: The Ultimate Solution to Antimicrobial Resistance in <i>Escherichia coli</i>?

“…Currently there is no clear standardization or regulation of the methodology in combination therapy [44], further complicated by different test methods, different EOs extraction methods and test assays. The most widely used techniques to detect synergy are the checkerboard and time-kill curve methods [33,[45][46][47][48]. In checkerboard assay, in which two test agents are tested individually in serial dilutions and in all combinations of these dilutions together to find the concentration of each test agent, both alone and in combination, that produce some specific antimicrobial effects i.e., minimal inhibitory concentration (MIC).…”